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Safety and Allele-Specific Immunogenicity of a Malaria Vaccine in Malian Adults: Results of a Phase I Randomized Trial
Objectives: The objectives were to evaluate the safety, reactogenicity, and allele-specific immunogenicity of the blood-stage malaria vaccine FMP1/AS02A in adults exposed to seasonal malaria and the impact of natural infection on vaccine-induced antibody levels. Design: We conducted a randomized…
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Artikel Jurnal Teks lengkap
Identification of the Proliferation/Differentiation Switch in the Cellular Network of Multicellular Organisms
The protein–protein interaction networks, or interactome networks, have been shown to have dynamic modular structures, yet the functional connections between and among the modules are less well understood. Here, using a new pipeline to integrate the interactome and the transcriptome, we identified…
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Artikel Jurnal Teks lengkap
A Translocated Bacterial Protein Protects Vascular Endothelial Cells from Apoptosis
The modulation of host cell apoptosis by bacterial pathogens is of critical importance for the outcome of the infection process. The capacity of Bartonella henselae and B. quintana to cause vascular tumor formation in immunocompromised patients is linked to the inhibition of vascular endothelial…
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Artikel Jurnal Teks lengkap
PLoS Biology Issue Image | Vol. 4(11) November 2006
Arthritic limbs from mice with autoimmune disease.: A dynamic tuning process restricts the responsiveness of autoreactive T cells, but its relative inefficiency in abrogating effector functionality results in arthritis and autoantibody production (bottom panels). Singh et al. examine the separable…
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Artikel Jurnal Teks lengkap
PLoS Medicine Issue Image | Vol. 3(11) November 2006
Placental Malaria and Preeclampsia.: The cover image is derived from photographs in the paper by Patrick Duffy and colleagues in which it is established that a younger woman in her first pregnancy who develops placental malaria is more likely than other mothers to suffer from preeclampsia, which…
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Artikel Jurnal Teks lengkap
Intellectual Property and Access to ART: Unwise Choice of Terminology
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Artikel Jurnal Teks lengkap
Are We Publishing “The Right Stuff”?
The findings of a major study inPLoS Medicine predicting mortality rates and the global burden of disease should inform health policy, and also the future content of medical journals.
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