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Contemporary HIV-1 envelope pseudovirus panels for detecting and assessing B cell lineages with broadly neutralizing antibody potential
Although a protective HIV-1 vaccine has not yet been realized, significant progress has been made in vaccine designs that trigger B cell lineages with potential to produce broadly neutralizing antibodies (bnAbs). Advancing these strategies by optimizing vaccine boosting regimens requires early…
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Sea urchin eggs contain a plastid-derived structure that contributes to their development
Development in the sea has long been thought to be a nutritional gamble that disproportionately ends in starvation. Here, we support the premise that components of plastids appear to be incorporated into sea urchin eggs and that these, in turn, benefit development. We find chromoplast-derived…
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The microscopic mechanism of water immersion and collapsibility in Malan loess with different particle size
Collapsibility of loess is a widespread, highly destructive geological hazard on the Chinese Loess Plateau. Malan loess exhibits distinct regional particle size variations, but the collapsible deformation characteristics and underlying microscopic mechanisms of loess with different particle sizes…
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Using tree-based ensemble methods to produce a population-based mortality risk score in Ontario, Canada
Introduction: Risk adjustment is critical in observational epidemiology to control for confounding of the exposure-outcome relationship. Accurate prediction of outcomes, such as mortality, can improve risk adjustment. In the present study, we compared logistic regression with a range of tree-based…
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Use of health communication materials by health-care providers for health education in low- and middle-income countries: A scoping review
Background: Health communication materials (HCMs) are widely used to support health education and promotion activities in clinical and community settings. However, evidence regarding their use by healthcare providers in low- and middle-income countries (LMICs) remains inconsistent. This scoping…
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Risk prediction of combined fibrinogen degradation products, thrombomodulin, and maximum amplitude for assessing association with venous thromboembolism in patients with post-traumatic fractures
Background: Venous thromboembolism (VTE) is a globally prevalent severe disease associated with high morbidity and mortality. Currently, thrombomodulin (TM), fibrinogen degradation product (FDP), thromboelastography have been the subject of several research pertaining to VTE; However, the combined…
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Plasma-activated water: Mechanism and treatment duration for postharvest disease control and shelf-life enhancement of mango under ambient storage
In Bangladesh, a large quantity of mango is lost every year due to post-harvest diseases, particularly anthracnose and stem-end rot. Therefore, sustainable post-harvest management is crucial for reducing the losses. In this study, we investigated the effects of plasma treatments on mango to…
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Quantification of pulmonary arterial pressure with 4D flow cardiac MRI velocity mapping in patients with suspected pulmonary hypertension: Comparison with right heart catheterization
Objectives: 4D flow MRI is becoming a promising tool to assess pulmonary hypertension which remains a progressive fatal disease. The aim of this study was to compare the quantification of pulmonary arterial pressure derived from 4D flow MRI with right heart catheterization in patients with…
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Effects of peppermint ( Mentha x piperita L.) oil on cardiometabolic outcomes in patients with pre- and stage 1 hypertension: A placebo randomized controlled trial
Hypertension represents the predominant risk factor for cardiovascular disease morbidity and mortality; with significant healthcare utilization and expenditure. Pharmaceutical management is habitually adopted; although its long-term effectiveness remains ambiguous, and accompanying adverse effects…
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A load forecasting method based on edge graph attention network
Given the increasing demand for high-accuracy power load forecasting, traditional load forecasting methods can capture long-term dependencies in time series, but cannot fully capture the complex relationships between multi-dimensional features. This paper proposes an innovative method to convert…
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Neural network architectures and normalization techniques for automated sleep stage classification using rodent EEG and EMG signals
Accurate sleep stage classification in animal models is crucial for translational sleep research, enabling the study of mechanistic pathways and therapeutic interventions. Because manual scoring is labor-intensive and variable, artificial neural networks are increasingly used for automation…
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Relationships between pre-pandemic mental health, sociodemographic factors and health behaviours in older adults during the acute onset of COVID-19 in Australia: A descriptive analysis
Objective: To gain a comprehensive understanding of associations between mental health symptoms and sociodemographic and health factors assessed during COVID-19 restrictions in existing, longitudinal community-based cohorts. Methods: Participants of The North West Adelaide Health Study (NWAHS, n =…
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Selective observation following betrayal shapes the social inference landscape
Despite limited access to others’ actions and outcomes, humans excel at inferring hidden intentions. Given only partial access, how do they decide what to observe, and how does selective observation shape inference? Here, we examined how choosing what to observe can bias the inference about others’…
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Look what you make my tissues do: The role of metalloproteinases and their inhibitors in Bothrops snakebites
Background: Bothrops envenomation induces extensive local tissue destruction and a robust inflammatory response, largely driven by the host’s endogenous molecular pathways. Among these, Matrix Metalloproteinases (MMPs), zinc-dependent endopeptidases responsible for extracellular matrix (ECM)…
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Prion shedding is reduced by chronic wasting disease vaccination
Chronic wasting disease (CWD) is a strictly fatal and highly contagious prion disease of wild and farmed cervids currently expanding in North America. Prion diseases are caused by conversion of the cellular prion protein to its pathological isoform PrPSc. Vaccination is considered a promising…
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Duck plague virus LORF2 utilizes RNF34 to inhibit antiviral innate immunity by ubiquitination and degradation of IRF7
Duck plague, caused by the alphaherpesvirus Duck plague virus (DPV), is an acute, hemorrhagic, and economically devastating disease of waterfowl. DPV infection induces severe immunosuppression, yet the mechanisms by which this pathogen subverts host innate immunity, particularly through…
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Structural basis for substrate recognition and inhibition of thioredoxin glutathione reductase from Schistosoma japonicum : Implications for antiparasitic development
Praziquantel (PZQ) is currently the only agent for treating schistosomiasis, but it is plagued by suboptimal efficacy to juvenile parasites, looming drug resistance, and inability to prevent reinfection. Thioredoxin glutathione reductase (TGR) is regarded as a promising therapeutic target due to…
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MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway
Porcine epidemic diarrhea virus (PEDV) poses a significant threat to the global swine industry; however, the host factors that support its replication remain poorly understood. Our previous study showed that myeloid cell leukemia 1 (MCL1) is a pro-PEDV replication cellular factor through…
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Voronoi tessellation as a complement or replacement for confidence ellipses in the visualization of data projection and clustering results
Visualizing two-dimensional data projections with group-wise coloring and confidence ellipses is a standard approach in biomedical data analysis. However, this method can obscure subtle group overlaps or atypical cases. Voronoi tessellation, which is widely used in crystallography to analyze local…
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