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Artikel Jurnal Teks lengkap
Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes
Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster than they would spontaneously cycle in vitro…
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Protein Homology Network Families Reveal Step-Wise Diversification of Type III and Type IV Secretion Systems
From the analysis of 251 prokaryotic genomes stored in public databases, the 761,260 deduced proteins were used to reconstruct a complete set of bacterial proteic families. Using the new Overlap algorithm, we have partitioned the Protein Homology Network (PHN), where the proteins are the nodes and…
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Artikel Jurnal Teks lengkap
Stochastic Processes Are Key Determinants of Short-Term Evolution in Influenza A Virus
Understanding the evolutionary dynamics of influenza A virus is central to its surveillance and control. While immune-driven antigenic drift is a key determinant of viral evolution across epidemic seasons, the evolutionary processes shaping influenza virus diversity within seasons are less clear…
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HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage–signaling protein ATR as the cellular factor that mediates Vpr-induced G2 arrest and apoptosis. Here, we examine the mechanism of induction of apoptosis by Vpr…
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Artikel Jurnal Teks lengkap
Endogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial Pathogens
Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis…
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Artikel Jurnal Teks lengkap
Impact of Antiretroviral Therapy on Intestinal Lymphoid Tissues in HIV Infection
Veazey and Lackner discuss a new study which found that most patients who start antiretroviral drugs as early as possible after HIV infection still do not experience complete restoration of intestinal CD4+ T cells to baseline levels.
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Artikel Jurnal Teks lengkap
Polarised Asymmetric Inheritance of Accumulated Protein Damage in Higher Eukaryotes
Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate…
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Artikel Jurnal Teks lengkap
Interspecific Communicative and Coordinated Hunting between Groupers and Giant Moray Eels in the Red Sea
Intraspecific group hunting has received considerable attention because of the close links between cooperative behaviour and its cognitive demands. Accordingly, comparisons between species have focused on behaviours that can potentially distinguish between the different levels of cognitive…
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Divergent Selection on Opsins Drives Incipient Speciation in Lake Victoria Cichlids
Divergent natural selection acting on ecological traits, which also affect mate choice, is a key element of ecological speciation theory, but has not previously been demonstrated at the molecular gene level to our knowledge. Here we demonstrate parallel evolution in two cichlid genera under strong…
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Artikel Jurnal Teks lengkap
The Structure of an RNAi Polymerase Links RNA Silencing and Transcription
RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it involves a…
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Artikel Jurnal Teks lengkap
Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly
Recently proposed models that have gained wide acceptance posit that HIV-1 virion morphogenesis is initiated by targeting the major structural protein (Gag) to late endosomal membranes. Thereafter, late endosome-based secretory pathways are thought to deliver Gag or assembled virions to the plasma…
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Artikel Jurnal Teks lengkap
The Malaria Atlas Project: Developing Global Maps of Malaria Risk
The primary goal of the recently launched Malaria Atlas Project is to develop the science of malaria cartography.
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Artikel Jurnal Teks lengkap
Intensive Insulin Therapy in Intensive Care: An Example of the Struggle to Implement Evidence-Based Medicine
Schultz and colleagues discuss the factors hindering implementation of intensive insulin therapy.
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Artikel Jurnal Teks lengkap
Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection
Background: During acute and early HIV-1 infection (AEI), up to 60% of CD4+ T cells in the lamina propria of the lower gastrointestinal (GI) tract are lost as early as 2–4 wk after infection. Reconstitution in the peripheral blood during therapy with highly active antiretroviral therapy (HAART) is…
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Artikel Jurnal Teks lengkap
Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens
Retroviral insertional mutagenesis screens, which identify genes involved in tumor development in mice, have yielded a substantial number of retroviral integration sites, and this number is expected to grow substantially due to the introduction of high-throughput screening techniques. The data of…
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