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Effects of N-acetyl-L-cysteine on sperm quality during chilled storage of Maguan hornless goat semen
The Maguan hornless goat is a valuable indigenous goat breed in Yunnan Province, China. As a rare and endangered genetic resource, its population protection and breeding are challenged by numerous challenges, particularly during artificial insemination procedures. During chilled storage, sperm…
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Successful student learning outcomes in Moroccan higher education: Causal configurations of pedagogical, motivational, and ICT conditions using fuzzy-set Qualitative Comparative Analysis (fsQCA)
As the demand for better educational quality and improved student performance grows, institutions face increasing challenges in making their teaching methods more effective to ensure successful learning outcomes. Most practical recommendations tend to focus on isolated effects, but learning success…
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Detecting apple replant disease in the field – deciphering reasons for local growth depression
Apple replant disease (ARD) arises from repeated apple (Malus domestica) planting in the same area, disrupting physiological and morphological plant functions. Recent studies demonstrated that ARD occurs locally with low mobility in soil. The patchy distribution of ARD makes field identification of…
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Rapid isometric hamstring strength scores from professional soccer players at pre-season: Positional differences and relationship to peak force
The assessment of rapid force within a single joint assessment is becoming common practice within elite sport environments. Recent observations have highlighted that rapid force maybe more sensitive to fatigue than peak force within the hamstrings. Yet limited information exists on rapid force…
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Irrigation and inequalities in the Senegal River Delta
Introduction: Irrigation is considered to be one of the best solutions to fight drought spells in agriculture but also to lift farmers out of poverty through improved water provision, and thus crop yields. However, irrigated agriculture, as organized in Africa, has often generated new inequalities…
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Effective coverage and associated factors of antenatal care service among women who attended antenatal care at West Gojjam Zone Public Hospitals, Northwest Ethiopia
Background: Effective coverage reflects the performance of a health system by integrating need, service utilization, and quality of care into a single measure. In many developing countries, inadequate effective coverage of antenatal care services along with poor quality maternal health services and…
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Validation and refinement of existing methods for timed mating and early pregnancy detection in guinea pigs
Biomedical research increasingly focuses on early developmental stages to better understand homeostasis, environmental influences, and disease origins, an approach summarised by the concept of the Developmental Origins of Health and Disease. However, studying these processes in humans is…
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Predicting student mental health through entropy-based features and interpretable cross-attention transformer networks
Mental health is becoming a major concern for students in today’s fast-changing world. Mental health challenges have impact on every aspect of life including performance which pointed to early identification of risk levels. Recent reports show a rapid rise in anxiety, depression, and stress among…
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Military personnel perspectives on participating in health research: A scoping review
Military service can significantly affect the health and wellbeing of current and former serving personnel. Although health research aims to address these impacts, little is known about how military personnel perceive such research. The aim of this scoping review was to investigate military…
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Risk-taking responses to crash experience: Evidence from China
This study examines the effect of fund managers’ crash experience on their risk-taking behaviors. Using China’s 2007–2008 and 2014–2015 A-share market crashes, as well as the COVID-19 pandemic, as exogenous shocks, we find that managers with crash experiences significantly increased their overall…
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Monotherapy cancer drug-blind response prediction is limited to intraclass generalization
Monotherapy cancer drug response prediction (DRP) models predict the response of a cell line to a given drug. Analyzing these models’ performance includes assessing their ability to predict the response of cell lines to new drugs, i.e., drugs that are not in the training set. Drug-blind prediction…
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Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in vitro and in vivo
Post-antibiotic effect (PAE) describes the delay in bacterial growth that continues after antibiotics are cleared. The physiologic basis of PAE in Mycobacterium tuberculosis (Mtb) remains poorly understood. Here, we evaluated the long-standing hypothesis that PAE reflects the time required for…
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Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles
Background & Aims: Hepatitis C virus (HCV) has the unique characteristic of forming lipo-viro-particles (LVPs), which are lipid-rich virions containing both the viral components and host apolipoproteins such as ApoB and E. This unique composition gives to LVPs a low buoyant density, facilitates…
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Enhancing generalizability of model discovery across parameter space with multi-experiment equation learning for biological systems
Agent-based modeling (ABM) is a powerful tool for understanding self-organizing biological systems, but it is computationally intensive and often not analytically tractable. Equation learning (EQL) methods can derive continuum models from ABM data, but they typically require extensive simulations…
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Live attenuated vaccination protects aged chimeric ACE2 mice from severe SARS-CoV-2 pathogenicity in vivo
Advanced age is one of the greatest risk factors for a severe outcome of COVID-19. Although mRNA vaccines were highly successful in protecting the elderly, the strongest increase in morbidity and mortality upon infection with emerging SARS-CoV-2 variants was among the elderly. To better understand…
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Structure of the human P2X3 receptor reveals the basis for subtype-selective inhibition by sivopixant
P2X receptors are ATP-gated cation channels, and the P2X3 subtype plays crucial roles in peripheral sensory neurons, including in chronic pain and chronic cough. Accordingly, P2X3 receptors have attracted substantial interest as a therapeutic target. Gefapixant, a negative allosteric modulator…
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DMAPLM: A multimodal pretrained framework for computational drug repositioning
Drug repositioning offers an efficient route to discover new therapeutic indications for existing drugs. However, current computational drug repositioning models often face challenges related to data scarcity, heterogeneity, and therefore limited generalizability. To address these limitations, this…
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Serological evidence of Borrelia turicatae in Raccoons ( Procyon lotor ) from an endemic focus of tick-borne relapsing fever in Mexico
Tick-borne relapsing fever is a neglected and overlooked disease. In Mexico, numerous historical reports document the distribution of Ornithodoros turicata, the vector of Borrelia turicatae, as well as human cases of infection. However, the enzootic cycle and reservoir hosts in Mexico remain…
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Using experimental results of protein design to guide biomolecular energy-function development
Computational models of macromolecules have many applications in biochemistry, but physical inaccuracies limit their utility. One class of models uses energy functions rooted in classical mechanics. The standard datasets used to train these models are limited in diversity, pointing to a need for…
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Ensemble forecasts of COVID-19 activity to support Australia’s pandemic response: 2020–22
During the COVID-19 pandemic, many countries used real-time data analyses, predictive modelling, and COVID-19 case forecasts, to incorporate emerging evidence into their decisions. In Australia, national and jurisdictional public health responses were informed by weekly ensemble forecasts of daily…
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