131 results for "Daniel Simancas-Racines"

Spatiotemporal clustering and epidemiological characterization of suicides in Ecuador, 2015–2023

Karina Lalangui-Vivanco; Emmanuelle Quentin; Yekaterina Altuna-Roshkova et al.

PLOS Global Public Health, Vol. 6 No. 9 · 2026 · English · DOAJ Scopus

Suicide is an important public health issue worldwide, especially among the young population. This study aimed to analyze the epidemiological characteristics and the spatial and temporal distribution of suicide at the provincial level in Ecuador between 2015 and 2023, using national mortality…

Also available at: DOAJ

Reconstructing severe acute respiratory infection dynamics from ICD-10 hospital discharge data: a 10-year analysis of 11.2 million discharges in Ecuador, 2014–2023

Jaime Angamarca-Iguago; Jaen Cagua-Ordónez; Juan Marcos Parise-Vasco et al.

Frontiers in Public Health, Vol. 14 · 2026 · English · DOAJ Scopus

BackgroundIn many low- and middle-income countries, surveillance of severe acute respiratory infections (SARI) relies on administrative hospital data without virological confirmation, and its ability to capture epidemic dynamics and age-specific burden remains uncertain.MethodsWe analyzed…

Timing matters: lipid intake and its influence on menopausal-related symptoms

Ludovica Verde; Luigi Barrea; Evelyn Frias-Toral et al.

Journal of Translational Medicine, Vol. 23 No. 1 · 2025 · English · DOAJ Scopus

Abstract Background Menopause contributes to central obesity and increases cardiovascular risk in women. Diet influences both menopausal symptoms and cardiovascular health, but the impact of chrononutrition, namely food timing, is not well understood. This cross-sectional study investigated whether…

Artificial intelligence for the detection of acute myeloid leukemia from microscopic blood images; a systematic review and meta-analysis

Feras Al-Obeidat; Wael Hafez; Asrar Rashid et al.

Frontiers in Big Data, Vol. 7 · 2025 · English · DOAJ Scopus

BackgroundLeukemia is the 11th most prevalent type of cancer worldwide, with acute myeloid leukemia (AML) being the most frequent malignant blood malignancy in adults. Microscopic blood tests are the most common methods for identifying leukemia subtypes. An automated optical image-processing system…

Multilevel barriers to clinical and nutritional research in Latin America: a socioeconomic comparative analysis

Evelyn Frias-Toral; Jaime Angamarca-Iguago; Isabel Calvo Higuera et al.

Frontiers in Nutrition, Vol. 12 · 2025 · English · DOAJ Scopus

IntroductionClinical and nutritional research in Latin America faces significant challenges that limit scientific development and evidence-based healthcare. Understanding these barriers is essential for developing effective strategies to enhance research capacity in the region. This study aimed to…

False-negative results of initial RT-PCR assays for COVID-19: A systematic review

Ingrid Arevalo-Rodriguez; Diana Buitrago-Garcia; Daniel Simancas-Racines et al.

PLOS ONE, Vol. 15 No. 12 · 2020 · English · PLOS Scopus

Background: A false-negative case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is defined as a person with suspected infection and an initial negative result by reverse transcription-polymerase chain reaction (RT-PCR) test, with a positive result on a subsequent test…

Use of phase angle as an indicator of overtraining in sport and physical training

Giuseppe Annunziata; Antonio Paoli; Evelyn Frias-Toral et al.

Journal of Translational Medicine, Vol. 22 No. 1 · 2024 · English · DOAJ Scopus

Abstract The use of bioelectrical impedance analysis (BIA) is now well established in healthcare as an essential support tool for patient management in various clinical settings. Its use in sports is rapidly expanding due to the valuable insights it offers, helping to better structure athletes’…

Oesophageal adenocarcinoma, obesity, and cancer: the role of nutrition in prevention and management

Claudia Reytor-González; Daniel Simancas-Racines; Emilia Jiménez-Flores et al.

Food and Agricultural Immunology, Vol. 36 No. 1 · 2025 · English · DOAJ Scopus

Oesophageal adenocarcinoma (EAC) is increasingly associated with obesity, metabolic dysfunction, and genetic predispositions. This review explores how nutritional factors interact with these risk elements, emphasizing the potential of dietary strategies in EAC prevention and management. Diets such…

Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders

Daniel Simancas-Racines; Claudia Reytor-González; Ana Karina Zambrano et al.

Food and Agricultural Immunology, Vol. 36 No. 1 · 2025 · English · DOAJ Scopus

The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by a carbohydrate intake of less than 50 g/day and a daily caloric intake of fewer than 800 kcal, which induces ketosis and facilitates significant weight loss. Evidence suggests that this…

Bioactive Natural Compounds in Triple-Negative Breast Cancer: Molecular Targets and Therapeutic Perspectives

Emilia Jiménez-Flores; Claudia Reytor-González; Dolores Jima Gavilanes et al.

Pharmaceuticals, Vol. 19 No. 4 · 2026 · English · DOAJ Scopus

Triple-negative breast cancer represents one of the most aggressive and therapeutically challenging subtypes of breast malignancies, characterized by marked biological heterogeneity, rapid progression, and limited targeted treatment options. Conventional therapies are frequently constrained by drug…

Molecular pathways and nutrigenomic review of insulin resistance development in gestational diabetes mellitus

Patricia Guevara-Ramírez; Elius Paz-Cruz; Santiago Cadena-Ullauri et al.

Frontiers in Nutrition, Vol. 10 · 2023 · English · DOAJ Scopus

Gestational diabetes mellitus is a condition marked by raised blood sugar levels and insulin resistance that usually occurs during the second or third trimester of pregnancy. According to the World Health Organization, hyperglycemia affects 16.9% of pregnancies worldwide. Dietary changes are the…

Micronutrient risk with GLP-1 receptor and dual incretin agonists in obesity: Mechanistic pathways, clinical signals, and a monitoring framework

Daniel Simancas-Racines; Martín Campuzano-Donoso; Gianluca Rossetti et al.

Obesity Pillars, Vol. 19 · 2026 · English · DOAJ Scopus

Background: Incretin-based pharmacotherapies, including GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists, have transformed obesity management by producing substantial weight loss through appetite suppression, reduced energy intake, and gastrointestinal effects. These mechanisms may also…

Effect of diet on the microbiota and immune system in patients with systemic lupus erythematosus

Viviana A. Ruiz-Pozo; Elius Paz-Cruz; Santiago Cadena-Ullauri et al.

Food and Agricultural Immunology, Vol. 35 No. 1 · 2024 · English · DOAJ Scopus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and organ damage. Studies indicate that diet significantly influences the gut microbiota, which, in turn, affects the immune system. This article explores gut microbiota dysbiosis in SLE…

Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis

Daniel Simancas-Racines; Ingrid Arevalo-Rodriguez; Gerard Urrutia et al.

Cardiology Research and Practice, Vol. 2019 · 2019 · English · DOAJ Scopus

Background. Leukocytes contained in the allogeneic packed red blood cell (PRBC) are the cause of certain adverse reactions associated with blood transfusion. Leukoreduction consists of eliminating leukocytes in all blood products below the established safety levels for any patient type. In this…

Impact of fundamental components of the Mediterranean diet on the microbiota composition in blood pressure regulation

Ana Karina Zambrano; Santiago Cadena-Ullauri; Viviana A. Ruiz-Pozo et al.

Journal of Translational Medicine, Vol. 22 No. 1 · 2024 · English · DOAJ Scopus

Abstract Background The Mediterranean diet (MedDiet) is a widely studied dietary pattern reflecting the culinary traditions of Mediterranean regions. High adherence to MedDiet correlates with reduced blood pressure and lower cardiovascular disease (CVD) incidence and mortality. Furthermore…

The effect of intermittent fasting on microbiota as a therapeutic approach in obesity

Santiago Cadena-Ullauri; Patricia Guevara-Ramírez; Viviana A. Ruiz-Pozo et al.

Frontiers in Nutrition, Vol. 11 · 2024 · English · DOAJ Scopus

Obesity, a public health challenge, arises from a complex interplay of factors such as dietary habits and genetic predisposition. Alterations in gut microbiota, characterized by an imbalance between Firmicutes and Bacteroidetes, further exacerbate metabolic dysregulation, promoting inflammation and…

Obstructive sleep apnea knowledge and attitudes among recent medical graduates training in Ecuador

Iván Chérrez-Ojeda; Juan Carlos Calderón; Andrea Fernández García et al.

Multidisciplinary Respiratory Medicine, Vol. 13 No. 1 · 2018 · English · DOAJ Scopus

Abstract Background We aimed to assess recent Latin American medical school graduates’ knowledge and attitudes about OSA and examine whether their knowledge and attitudes about OSA differed from practicing physicians. Methods Recent medical graduates completed the Spanish translation of the OSA…

Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review

Ana Karina Zambrano; Elius Paz-Cruz; Viviana A. Ruiz-Pozo et al.

Frontiers in Nutrition, Vol. 11 · 2024 · English · DOAJ Scopus

The review present data on the intricate relationship between bariatric surgery, gut microbiota, and metabolic health in obesity treatment. Bariatric surgery, is recognized as an effective intervention for managing morbid obesity, including various techniques with distinct mechanisms of action…

Molecular mechanisms of semaglutide and liraglutide as a therapeutic option for obesity

Rafael Tamayo-Trujillo; Viviana A. Ruiz-Pozo; Santiago Cadena-Ullauri et al.

Frontiers in Nutrition, Vol. 11 · 2024 · English · DOAJ Scopus

Obesity, a chronic global health problem, is associated with an increase in various comorbidities, such as cardiovascular disease, type 2 diabetes mellitus, hypertension, and certain types of cancer. The increasing global prevalence of obesity requires research into new therapeutic strategies…