15 hasil untuk "A. Ruby"

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A. Ruby Buxton

March Bros., Publishers · 1920 · Inggris · Open Library

Minimal Reinhard Zumkeller divisor cordial graphs

A . Ruby Priscilla; S.Firthous Fatima

Ratio Mathematica, Vol. 47 No. 0 · 2023 · Inggris · DOAJ

How Sediment Supply, Sea‐Level, and Glacial Isostatic Oscillations Drive Alluvial River Long‐Profile Evolution and Terrace Formation

A. Ruby; F. McNab; T. F. Schildgen dkk.

AGU Advances, Vol. 7 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract For over a century, alluvial river terraces have been used as archives of tectonic deformation or changes in water discharge, sediment supply, and sea level. Despite this long history, such efforts remain challenging: using terraces as deformation markers requires knowledge of their…

VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

Maxwell A. Ruby; Benjamin Goldenson; Gabriela Orasanu dkk.

Journal of Lipid Research, Vol. 51 No. 8 · 2010 · Inggris · DOAJ Scopus

Recent evidence suggests that lipoproteins serve as circulating reservoirs of peroxisomal proliferator activated receptor (PPAR) ligands that are accessible through lipolysis. The present study was conducted to determine the biochemical basis of PPAR-α activation by lipolysis products and their…

Acute Overactive Endocannabinoid Signaling Induces Glucose Intolerance, Hepatic Steatosis, and Novel Cannabinoid Receptor 1 Responsive Genes

Maxwell A. Ruby; Daniel K. Nomura; Carolyn S. S. Hudak dkk.

PLoS ONE, Vol. 6 No. 11 · 2011 · Inggris · PLOS Scopus

Endocannabinoids regulate energy balance and lipid metabolism by stimulating the cannabinoid receptor type 1 (CB1). Genetic deletion and pharmacological antagonism have shown that CB1 signaling is necessary for the development of obesity and related metabolic disturbances. However, the sufficiency…

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Tissue-Protective Effects of NKG2A in Immune-Mediated Clearance of Virus Infection

Kenneth H. Ely; Mitsuo Matsuoka; Matthew P. DeBerge dkk.

PLoS ONE, Vol. 9 No. 9 · 2014 · Inggris · PLOS Scopus

Virus infection triggers a CD8+ T cell response that aids in virus clearance, but also expresses effector functions that may result in tissue injury. CD8+ T cells express a variety of activating and inhibiting ligands, though regulation of the expression of inhibitory receptors is not well…

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Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients

Henriette Kirchner; Indranil Sinha; Hui Gao dkk.

Molecular Metabolism, Vol. 5 No. 3 · 2016 · Inggris · DOAJ Scopus

Objective: Epigenetic modifications contribute to the etiology of type 2 diabetes. Method: We performed genome-wide methylome and transcriptome analysis in liver from severely obese men with or without type 2 diabetes and non-obese men to discover aberrant pathways underlying the development of…

Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion

Iwona Szczerbinska; Annamaria Tessitore; Lena Kristina Hansson dkk.

Biomedicines, Vol. 10 No. 1 · 2022 · Inggris · DOAJ Scopus

Type 2 diabetes (T2D) is a chronic metabolic disorder affecting almost half a billion people worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an underlying factor in the pathophysiology of the disease. Understanding the cellular mechanisms regulating appropriate…

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Maxwell A. Ruby; Julie Massart; Devon M. Hunerdosse dkk.

Cell Reports, Vol. 18 No. 3 · 2017 · Inggris · DOAJ Scopus

Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to gain mechanistic insight into the…

The TANDEM Euratom project: Context, objectives and workplan

C. Vaglio-Gaudard; M.T. Dominguez Bautista; M. Frignani dkk.

Nuclear Engineering and Technology, Vol. 56 No. 3 · 2024 · Inggris · DOAJ Scopus

The TANDEM project is a European initiative funded under the EURATOM program. The project started on September 2022 and has a duration of 36 months. TANDEM stands for Small Modular ReacTor for a European sAfe aNd Decarbonized Energy Mix.Small Modular Reactors (SMRs) can be hybridized with other…

Hepatocyte mARC1 promotes fatty liver disease

Lara C. Lewis; Lingyan Chen; L. Shahul Hameed dkk.

JHEP Reports, Vol. 5 No. 5 · 2023 · Inggris · DOAJ Scopus

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new therapeutics. Genetic variants in mitochondrial…

Expanding the Diversity of Mycobacteriophages: Insights into Genome Architecture and Evolution

Welkin H. Pope; Deborah Jacobs-Sera; Daniel A. Russell dkk.

PLoS ONE, Vol. 6 No. 1 · 2011 · Inggris · PLOS Scopus

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable…

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