5 hasil untuk "Agnese Fragassi"
Menampilkan 1–5 · 0,24 detik · RSS
-
Artikel Jurnal Teks lengkap
Lubricant Strategies in Osteoarthritis Treatment: Transitioning from Natural Lubricants to Drug Delivery Particles with Lubricant Properties
Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, leading to pain and functional impairment. A key contributor to OA progression is the decline in cartilage lubrication. In physiological conditions, synovial fluid (SF) macromolecules like hyaluronic acid…
-
Artikel Jurnal
Folate-targeted gold nanoparticles for doxorubicin delivery in tumor spheroids
Targeted drug delivery systems represent a promising strategy for enhancing the efficacy and specificity of cancer therapy. In this study, 35 nm folate-targeted gold nanoparticles are presented as nanoparticle–drug conjugates obtained by anchoring on their surface lipoyl terminating doxorubicin…
-
Artikel Jurnal
Breakable Organosilica Nanocapsules for the Intracellular Delivery of a Peptide With Promising Anti‐Breast Cancer Activity
High‐mobility group box 1 (HMGB1) is a protein acting as a regulator in tumor progression and therapy resistance, including breast cancer. HBP08‐2, a novel HMGB1‐inhibiting peptide, showed promising therapeutic potential; however, its poor stability and susceptibility to degradation limit cellular…
-
Artikel Jurnal
Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer
Abstract Nano- and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications, from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic joints. Here, we assessed the tribological properties of a…
-
Artikel Jurnal
Sustained release of exogeneous fetuin-A from Hyaluronic acid microplates decreases joint degeneration, synovial hyperplasia and muscle damage in a murine post-traumatic osteoarthritis model
Abstract Background Fetuin-A is a glycoprotein with high affinity for calcium-phosphates, with a role in cartilage and bone metabolism, and an anti-inflammatory role in injury. Studies have shown decreasing serum fetuin-A levels in patients with severe osteoarthritis (OA), and lower amounts of…