80 hasil untuk "Akash"
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Artikel Jurnal Teks lengkap
Effect of Reference Genome Selection on the Performance of Computational Methods for Genome-Wide Protein-Protein Interaction Prediction
Background: Recent progress in computational methods for predicting physical and functional protein-protein interactions has provided new insights into the complexity of biological processes. Most of these methods assume that functionally interacting proteins are likely to have a shared…
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Evaluation of Physical and Functional Protein-Protein Interaction Prediction Methods for Detecting Biological Pathways
Background: Cellular activities are governed by the physical and the functional interactions among several proteins involved in various biological pathways. With the availability of sequenced genomes and high-throughput experimental data one can identify genome-wide protein-protein interactions…
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Implementation of remote-sensing models to identify post-disaster health facility damage: Comparative approaches to the 2023 earthquake in Turkey
Earthquakes and other disasters often cause substantial damage to health facilities, impacting short-term response capacity and long-term health system needs. Identifying health facility damage following disasters is therefore crucial for coordinating response, but ground-based evaluations require…
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The livestock drinking water system as an active reservoir for antimicrobial resistance: A systematic review and one health gap analysis
Livestock drinking water distribution systems represent a critical but understudied interface in the epidemiology of antimicrobial resistance. While engineered for production, these systems frequently function as unintended bioreactors where biofilms protect pathogens and facilitate horizontal gene…
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Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation
The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in their 3’ or 5’ untranslated region (UTR). Multiple lines of experimental evidence suggest that this process plays a key role in…
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Structural bioinformatics studies of bacterial outer membrane beta-barrel transporters and their AlphaFold2 predicted water-soluble QTY variants
Beta-barrel outer membrane proteins (OMP) are integral components of Gram-negative bacteria, eukaryotic mitochondria, and chloroplasts. They play essential roles in various cellular processes including nutrient transport, membrane stability, host-pathogen interactions, antibiotic resistance and…
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Cognitive load and prefrontal neuromodulation shape exploration, risk-taking, and information seeking in experience-based decision making
Experience-based decision making requires individuals to balance exploration and exploitation under uncertainty, a balance that may be influenced by cognitive demands and prefrontal neuromodulation. We examined the joint effects of trivia-based cognitive load and anodal transcranial direct current…
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Non-Disclosure of Violence among Female Sex Workers: Evidence from a Large Scale Cross-Sectional Survey in India
Objective: One of the indicators critical to the success of violence reduction programmes among female sex workers (FSWs) is the pattern of disclosure of violence. This study examines the rate of non-disclosure of violence among FSWs in India by perpetrators of violence and programme exposure…
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A student-led pilot lecture in nutrition as a catalyst for curriculum change: A case study from one medical school
Background: Poor diet is the leading cause of global disability and premature death, contributing to 11 million deaths annually. Despite this, nutrition remains underemphasized in medical education, with over 70% of United States (U.S.) medical schools failing to meet the National Research…
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Systematic benchmarking of deep-learning methods for tertiary RNA structure prediction
The 3D structure of RNA critically influences its functionality, and understanding this structure is vital for deciphering RNA biology. Experimental methods for determining RNA structures are labour-intensive, expensive, and time-consuming. Computational approaches have emerged as valuable tools…
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Analyzing greedy vaccine allocation algorithms for metapopulation disease models
As observed in the case of COVID-19, effective vaccines for an emerging pandemic tend to be in limited supply initially and must be allocated strategically. The allocation of vaccines can be modeled as a discrete optimization problem that prior research has shown to be computationally difficult…
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Sustained Delivery of IL-1Ra from PF127-Gel Reduces Hyperglycemia in Diabetic GK-Rats
Interleukin-1beta (IL-1β) is a major cause for induction of various inflammatory mechanisms that are decisively involved to provoke pathogenesis of type 2 diabetes mellitus (T2DM). Interleukin-1 receptor antagonist (IL-1Ra) a naturally occurring anti-inflammatory antagonist of IL-1β has been…
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Poor adherence to TB diagnosis guidelines among under-five children with severe acute malnutrition in central India: A missed window of opportunity?
Background: In India, under-five children with Severe Acute Malnutrition (SAM) are referred to Nutritional Rehabilitation Centers (NRCs). NRCs screen the causes of SAM including tuberculosis (TB). The national TB programme recommends upfront testing with a rapid molecular test if TB is suspected in…
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Novel E3 Ubiquitin Ligases That Regulate Histone Protein Levels in the Budding Yeast Saccharomyces cerevisiae
Core histone proteins are essential for packaging the genomic DNA into chromatin in all eukaryotes. Since multiple genes encode these histone proteins, there is potential for generating more histones than what is required for chromatin assembly. The positively charged histones have a very high…
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Plasmodium falciparum UvrD Helicase Translocates in 3′ to 5′ Direction, Colocalizes with MLH and Modulates Its Activity through Physical Interaction
Malaria is a global disease and a major health problem. The control of malaria is a daunting task due to the increasing drug resistance. Therefore, there is an urgent need to identify and characterize novel parasite specific drug targets. In the present study we report the biochemical…
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Modified FlowCAM procedure for quantifying size distribution of zooplankton with sample recycling capacity
We have developed a modified FlowCAM procedure for efficiently quantifying the size distribution of zooplankton. The modified method offers the following new features: 1) prevents animals from settling and clogging with constant bubbling in the sample container; 2) prevents damage to sample animals…
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Household expenditure on leprosy outpatient services in the Indian health system: A comparative study
Background: Leprosy is a major public health problem in many low and middle income countries, especially in India, and contributes considerably to the global burden of the disease. Leprosy and poverty are closely associated, and therefore the economic burden of leprosy is a concern. However…
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Amblyceps waikhomi , a New Species of Catfish (Siluriformes: Amblycipitidae) from the Brahmaputra Drainage of Arunachal Pradesh, India
Amblyceps waikhomi sp. nov. is described from the Nongkon stream which drains into the Noa Dehing River, a tributary of the Brahmaputra River, in Arunachal Pradesh, India. The new species can be distinguished from congeners (except A. torrentis) in having a deeper body depth at anus. It further…
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Lupenone, a wonder chemical obtained from Euphorbia segetalis to boost affinity for the transcriptional factor escalating drought-tolerance in Solanum Lycopersicum : A cutting-edge computational biology approach
Drought is the single greatest abiotic factor influencing crop yield worldwide. Plants remain in one area for extended periods, making them vulnerable to natural and man-made influences. Understanding plant drought responses will help us develop strategies for breeding drought-resistant crops…
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Socioeconomic inequalities in access to maternal healthcare in South-Asian countries: A systematic review
Background: Despite numerous efforts, South Asia is the second most leading region for maternal mortality and morbidity. Although there have been notable advancements on this continent, progress in maternal healthcare access has been slow. Inequalities remain in different maternal health services…