21 results for "Alexis Robitaille"

RedoxiBase: A database for ROS homeostasis regulated proteins

Bruno Savelli; Qiang Li; Mark Webber et al.

Redox Biology, Vol. 26 · 2019 · English · DOAJ Scopus

We present a new database, specifically devoted to ROS homeostasis regulated proteins. This database replaced our previous database, the PeroxiBase, which was focused only on various peroxidase families. The addition of 20 new protein families related with ROS homeostasis justifies the new name for…

PVAmpliconFinder: a workflow for the identification of human papillomaviruses from high-throughput amplicon sequencing

Alexis Robitaille; Rosario N. Brancaccio; Sankhadeep Dutta et al.

BMC Bioinformatics, Vol. 21 No. 1 · 2020 · English · DOAJ Scopus

Abstract Background The detection of known human papillomaviruses (PVs) from targeted wet-lab approaches has traditionally used PCR-based methods coupled with Sanger sequencing. With the introduction of next-generation sequencing (NGS), these approaches can be revisited to integrate the sequencing…

SARS‐CoV‐2 outbreak investigation in a German meat processing plant

Thomas Günther; Manja Czech‐Sioli; Daniela Indenbirken et al.

EMBO Molecular Medicine, Vol. 12 No. 12 · 2020 · English · DOAJ Scopus

Abstract We describe a multifactorial investigation of a SARS‐CoV‐2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were…

Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection

Dominik Nörz; Moritz Grunwald; Hui Ting Tang et al.

Diagnostics, Vol. 11 No. 10 · 2021 · English · DOAJ Scopus

Background: The recent emergence of distinct and highly successful SARS-CoV-2 lineages has substantial implications for individual patients and public health measures. While next-generation-sequencing is routinely performed for surveillance purposes, RT-qPCR can be used to rapidly rule-in or…

Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants

Dominik Nörz; Moritz Grunwald; Hui Ting Tang et al.

Viruses, Vol. 14 No. 3 · 2022 · English · DOAJ Scopus

Background: The recently emerged SARS-CoV-2 B.1.1.529 lineage and its sublineages (Omicron variant) pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available monoclonal antibody therapies…

Human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression

Maria Carmen Romero-Medina; Assunta Venuti; Giusi Melita et al.

PLOS Pathogens, Vol. 16 No. 8 · 2020 · English · PLOS Scopus

Tumor suppressors can exert pro-proliferation functions in specific contexts. In the beta human papillomavirus type 38 (HPV38) experimental model, the viral proteins E6 and E7 promote accumulation of a wild-type (WT) p53 form in human keratinocytes (HKs), promoting cellular proliferation…

Also available at: DOAJ

Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice

Daniele Viarisio; Karin Müller-Decker; Rosita Accardi et al.

PLOS Pathogens, Vol. 14 No. 1 · 2018 · English · PLOS Scopus

Cutaneous beta human papillomavirus (HPV) types are suspected to be involved, together with ultraviolet (UV) radiation, in the development of non-melanoma skin cancer (NMSC). Studies in in vitro and in vivo experimental models have highlighted the transforming properties of beta HPV E6 and E7…

Also available at: DOAJ

Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 Proteins

Lucia Minoni; Maria Carmen Romero-Medina; Assunta Venuti et al.

mSphere, Vol. 5 No. 4 · 2020 · English · DOAJ Scopus

ABSTRACT The beta human papillomaviruses (HPVs) are subdivided into 5 species (beta-1 to beta-5), and they were first identified in the skin. However, the beta-3 species appears to be more highly represented in the mucosal epithelia than in the skin. Functional studies have also highlighted that…

Also available at: DOAJ

HPV38 impairs UV-induced transcriptional activation of the IL-18 pro-inflammatory cytokine

Maria Grazia Ceraolo; Maria Carmen Romero-Medina; Simone Gobbato et al.

mSphere, Vol. 8 No. 6 · 2023 · English · DOAJ Scopus

ABSTRACTIncreasing evidence suggests that the beta genus of human papillomavirus (β-HPV) cooperates with ultraviolet B (UVB) radiation in inducing non-melanoma skin cancer (NMSC). For instance, expression of E6 and E7 oncoproteins from cutaneous human papillomavirus type 38 (HPV38) in a transgenic…

The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells

Valerio Taverniti; Hanna Krynska; Assunta Venuti et al.

mSphere, Vol. 8 No. 2 · 2023 · English · DOAJ Scopus

ABSTRACT Tumor suppressor p53 and its related proteins, p63 and p73, can be synthesized as multiple isoforms lacking part of the N- or C-terminal regions. Specifically, high expression of the ΔNp73α isoform is notoriously associated with various human malignancies characterized by poor prognosis…

Detection of human papillomaviruses in paired healthy skin and actinic keratosis by next generation sequencing

Luisa Galati; Rosario Nicola Brancaccio; Alexis Robitaille et al.

Papillomavirus Research, Vol. 9 · 2020 · English · DOAJ

Actinic keratosis (AK) arises on photo-damaged skin and is considered to be the precursor lesion of cutaneous squamous cell carcinoma (cSCC). Many findings support the involvement of β human papillomaviruses (HPVs) in cSCC, while very little is known on γ HPV types. The objective of this study was…

Oral Infection by Mucosal and Cutaneous Human Papillomaviruses in the Men Who Have Sex with Men from the OHMAR Study

Tarik Gheit; Francesca Rollo; Rosario N Brancaccio et al.

Viruses, Vol. 12 No. 8 · 2020 · English · DOAJ Scopus

Both mucosal and cutaneous Human Papillomaviruses (HPVs) can be detected in the oral cavity, but investigations regarding the epidemiology of cutaneous HPVs at this site are scarce. We assessed mucosal (alpha) and cutaneous (beta and gamma) HPV infection in oral samples of HIV-infected and…

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β

Michelle Ainouze; Pauline Rochefort; Peggy Parroche et al.

PLOS Pathogens, Vol. 14 No. 8 · 2018 · English · PLOS Scopus

Human papillomavirus type 16 (HPV16) and other oncoviruses have been shown to block innate immune responses and to persist in the host. However, to avoid viral persistence, the immune response attempts to clear the infection. IL-1β is a powerful cytokine produced when viral motifs are sensed by…

Also available at: DOAJ

Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples

Luisa Galati; Purnima Gupta; Antonio Tufaro et al.

Infectious Agents and Cancer, Vol. 18 No. 1 · 2023 · English · DOAJ Scopus

Abstract Background Although the role of viral agents, such as human papillomavirus (e.g. HPV16, HPV18) in colorectal cancer (CRC) has been previously investigated, results remain inconclusive. Methods To further evaluate the involvement of oncogenic HPV types in CRC, 40 frozen neoplastic and 40…

Molecular features of premenopausal breast cancers in Latin American women: Pilot results from the PRECAMA study

Magali Olivier; Liacine Bouaoun; Stephanie Villar et al.

PLOS ONE, Vol. 14 No. 1 · 2019 · English · PLOS Scopus

Background: In Latin America (LA), there is a high incidence rate of breast cancer (BC) in premenopausal women, and the genomic features of these BC remain unknown. Here, we aim to characterize the molecular features of BC in young LA women within the framework of the PRECAMA study, a multicenter…

SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies

Thomas Theo Brehm; Susanne Pfefferle; Ronald von Possel et al.

Viruses, Vol. 13 No. 4 · 2021 · English · DOAJ Scopus

So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to…