90 hasil untuk "Ankit"

Analysis of rural broadband adoption dynamics: A theory-driven agent-based model

Ankit Agarwal; Casey Canfield

PLOS ONE, Vol. 19 No. 6 · 2024 · Inggris · PLOS Scopus

Demand for broadband internet has far outpaced its availability. In addition, the “new normal” imposed by the COVID-19 pandemic has further disadvantaged unserved and underserved areas. To address this challenge, federal and state agencies are funding internet service providers (ISPs) to deploy…

An Antitubulin Agent BCFMT Inhibits Proliferation of Cancer Cells and Induces Cell Death by Inhibiting Microtubule Dynamics

Ankit Rai; Avadhesha Surolia; Dulal Panda

Public Library of Science · 2012 · Inggris · PLOS Scopus

Using cell based screening assay, we identified a novel anti-tubulin agent (Z)-5-((5-(4-bromo-3-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one (BCFMT) that inhibited proliferation of human cervical carcinoma (HeLa) (IC50, 7.2±1.8 µM), human breast adenocarcinoma (MCF-7) (IC50…

A Scalable Computational Framework for Establishing Long-Term Behavior of Stochastic Reaction Networks

Ankit Gupta; Corentin Briat; Mustafa Khammash

PLoS Computational Biology, Vol. 10 No. 6 · 2014 · Inggris · PLOS Scopus

Reaction networks are systems in which the populations of a finite number of species evolve through predefined interactions. Such networks are found as modeling tools in many biological disciplines such as biochemistry, ecology, epidemiology, immunology, systems biology and synthetic biology. It is…

DeepCME: A deep learning framework for computing solution statistics of the chemical master equation

Ankit Gupta; Christoph Schwab; Mustafa Khammash

PLOS Computational Biology, Vol. 17 No. 12 · 2021 · Inggris · PLOS Scopus

Stochastic models of biomolecular reaction networks are commonly employed in systems and synthetic biology to study the effects of stochastic fluctuations emanating from reactions involving species with low copy-numbers. For such models, the Kolmogorov’s forward equation is called the chemical…

Chikungunya virus infection in Aedes aegypti is modulated by L-cysteine, taurine, hypotaurine and glutathione metabolism

Ankit Kumar; Jatin Shrinet; Sujatha Sunil

PLOS Neglected Tropical Diseases, Vol. 17 No. 5 · 2023 · Inggris · PLOS Scopus

Background: Blood meal and infections cause redox imbalance and oxidative damage in mosquitoes which triggers the mosquito’s system to produce antioxidants in response to increased oxidative stress. Important pathways activated owing to redox imbalance include taurine, hypotaurine and glutathione…

Methamphetamine Alters the Normal Progression by Inducing Cell Cycle Arrest in Astrocytes

Austin R. Jackson; Ankit Shah; Anil Kumar

PLoS ONE, Vol. 9 No. 10 · 2014 · Inggris · PLOS Scopus

Methamphetamine (MA) is a potent psychostimulant with a high addictive capacity, which induces many deleterious effects on the brain. Chronic MA abuse leads to cognitive dysfunction and motor impairment. MA affects many cells in the brain, but the effects on astrocytes of repeated MA exposure is…

Revolutionizing attention deficit hyperactivity disorder with artificial intelligence

Archana Reddy Bongurala; Dhaval Save; Ankit Virmani

PLOS Mental Health, Vol. 1 No. 6 · 2024 · Inggris · PLOS Scopus

Cognitive load and prefrontal neuromodulation shape exploration, risk-taking, and information seeking in experience-based decision making

Ankit Singh; Varun Dutt; Akash K. Rao

PLOS One, Vol. 21 No. 10 · 2026 · Inggris · PLOS Scopus

Experience-based decision making requires individuals to balance exploration and exploitation under uncertainty, a balance that may be influenced by cognitive demands and prefrontal neuromodulation. We examined the joint effects of trivia-based cognitive load and anodal transcranial direct current…

Cortical Reorganisation during a 30-Week Tinnitus Treatment Program

Catherine M. McMahon; Ronny K. Ibrahim; Ankit Mathur

PLOS ONE, Vol. 11 No. 2 · 2016 · Inggris · PLOS Scopus

Subjective tinnitus is characterised by the conscious perception of a phantom sound. Previous studies have shown that individuals with chronic tinnitus have disrupted sound-evoked cortical tonotopic maps, time-shifted evoked auditory responses, and altered oscillatory cortical activity. The main…

Prophylactic efficacy of Quercetin in ameliorating the hypoxia induced vascular leakage in lungs of rats

Ankit Tripathi; Bhuvnesh Kumar; Sarada S. K. Sagi

PLOS ONE, Vol. 14 No. 6 · 2019 · Inggris · PLOS Scopus

The objective of the study was to find out the prophylactic efficacy of Quercetin in ameliorating the hypoxia induced vascular leakage in lungs of rats. Male SD rats received different doses of quercetin @ 25mg, 50mg, 100mg and 200mg/Kg BW, 1h prior to hypobaric hypoxia exposure (7,620m, for 6h)…

Genetic diversity of Ralstonia solanacearum causing vascular bacterial wilt under different agro-climatic regions of West Bengal, India

Ankit Kumar Ghorai; Subrata Dutta; Ashis Roy Barman

PLOS ONE, Vol. 17 No. 9 · 2022 · Inggris · PLOS Scopus

The bacterial wilt disease of solanaceous crops incited by Ralstonia solanacearum is a menace to the production of solanaceous vegetables all over the world. Among the agro climatic zones of West Bengal, India growing solanaceous vegetables, the maximum and minimum incidence of bacterial wilt was…

Improving sepsis prediction in intensive care with SepsisAI : A clinical decision support system with a focus on minimizing false alarms

Ankit Gupta; Ruchi Chauhan; Saravanan G dkk.

PLOS Digital Health, Vol. 3 No. 8 · 2024 · Inggris · PLOS Scopus

Prediction of sepsis using machine-learning approaches has recently gained traction. However, the lack of translation of these algorithms into clinical routine remains a major issue. Existing early sepsis detection methods are either based on the older definition of sepsis or do not accurately…

Chamber Specific Gene Expression Landscape of the Zebrafish Heart

Angom Ramcharan Singh; Ambily Sivadas; Ankit Sabharwal dkk.

PLOS ONE, Vol. 11 No. 1 · 2016 · Inggris · PLOS Scopus

The organization of structure and function of cardiac chambers in vertebrates is defined by chamber-specific distinct gene expression. This peculiarity and uniqueness of the genetic signatures demonstrates functional resolution attributed to the different chambers of the heart. Altered expression…

Conditional permeabilization of the P . falciparum plasma membrane in infected cells links cation influx to reduced membrane integrity

Mariame Sylla; Ankit Gupta; Jinfeng Shao dkk.

PLOS ONE, Vol. 18 No. 4 · 2023 · Inggris · PLOS Scopus

The intracellular human malaria parasite, Plasmodium falciparum, uses the PfATP4 cation pump to maintain Na+ and H+ homeostasis in parasite cytosol. PfATP4 is the target of advanced antimalarial leads, which produce many poorly understood metabolic disturbances within infected erythrocytes. Here…

Characterization of the Biosynthesis, Processing and Kinetic Mechanism of Action of the Enzyme Deficient in Mucopolysaccharidosis IIIC

Xiaolian Fan; Ilona Tkachyova; Ankit Sinha dkk.

PLoS ONE, Vol. 6 No. 9 · 2011 · Inggris · PLOS Scopus

Heparin acetyl-CoA:alpha-glucosaminide N-acetyltransferase (N-acetyltransferase, EC 2.3.1.78) is an integral lysosomal membrane protein containing 11 transmembrane domains, encoded by the HGSNAT gene. Deficiencies of N-acetyltransferase lead to mucopolysaccharidosis IIIC. We demonstrate that…

HIV-1 Tat-Mediated Induction of CCL5 in Astrocytes Involves NF-κB, AP-1, C/EBPα and C/EBPγ Transcription Factors and JAK, PI3K/Akt and p38 MAPK Signaling Pathways

Anantha R. Nookala; Ankit Shah; Richard J. Noel dkk.

PLoS ONE, Vol. 8 No. 11 · 2013 · Inggris · PLOS Scopus

The incidence of HIV-associated neurological disorders (HAND) has increased during recent years even though the highly active antiretroviral therapy (HAART) has significantly curtailed the virus replication and increased the life expectancy among HIV-1 infected individuals. These neurological…

Discovering vesicle traffic network constraints by model checking

Ankit Shukla; Arnab Bhattacharyya; Lakshmanan Kuppusamy dkk.

PLOS ONE, Vol. 12 No. 7 · 2017 · Inggris · PLOS Scopus

A eukaryotic cell contains multiple membrane-bound compartments. Transport vesicles move cargo between these compartments, just as trucks move cargo between warehouses. These processes are regulated by specific molecular interactions, as summarized in the Rothman-Schekman-Sudhof model of vesicle…

MP3: A Software Tool for the Prediction of Pathogenic Proteins in Genomic and Metagenomic Data

Ankit Gupta; Rohan Kapil; Darshan B. Dhakan dkk.

PLoS ONE, Vol. 9 No. 4 · 2014 · Inggris · PLOS Scopus

The identification of virulent proteins in any de-novo sequenced genome is useful in estimating its pathogenic ability and understanding the mechanism of pathogenesis. Similarly, the identification of such proteins could be valuable in comparing the metagenome of healthy and diseased individuals…

Modeling and Inferring Cleavage Patterns in Proliferating Epithelia

Ankit B. Patel; William T. Gibson; Matthew C. Gibson dkk.

PLoS Computational Biology, Vol. 5 No. 6 · 2009 · Inggris · PLOS Scopus

The regulation of cleavage plane orientation is one of the key mechanisms driving epithelial morphogenesis. Still, many aspects of the relationship between local cleavage patterns and tissue-level properties remain poorly understood. Here we develop a topological model that simulates the dynamics…

Human Cell Chips: Adapting DNA Microarray Spotting Technology to Cell-Based Imaging Assays

Traver Hart; Alice Zhao; Ankit Garg dkk.

PLoS ONE, Vol. 4 No. 10 · 2009 · Inggris · PLOS Scopus

Here we describe human spotted cell chips, a technology for determining cellular state across arrays of cells subjected to chemical or genetic perturbation. Cells are grown and treated under standard tissue culture conditions before being fixed and printed onto replicate glass slides, effectively…