14 hasil untuk "B. Stephan"
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Artikel Jurnal Teks lengkap
Die nachweisbaren Strukturen der Federn von Archaeopteryx mit Anmerkungen zu Longisquama und diversen Proavis-Modellen
Die Abstammung der Vögel, die Entwicklung des Vogelfluges und die Evolution der Vogelfeder sind die zentralen Themen, die sehr kontrovers diskutiert werden und bei denen Archaeopteryx als Taxon oder als Modell für die evolutiven Prozesse eine wesentliche Bedeutung zukommt. Dass der erste Fund von…
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Artikel Jurnal
The Political Economy of Extraterritoriality
Near the end of the 2009 Term the Supreme Court decided Morrison v. Australia National Bank, Ltd., the strongest anti-extraterritoriality opinion it has produced in modern times. Not only is Congress presumed generally to prefer only territorial regulation, but lower courts that had carved out…
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Artikel Jurnal
What Should We Ask Reputation to Do?
Kristina Daugirdas's important new article prompts two kinds of responses. By providing a sophisticated analysis of the role of reputation in influencing the behavior of international actors, it invites further thoughts about what we might think reputation is and does. By taking a moral…
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Artikel Jurnal Teks lengkap
Book Review: Has Globalization Gone Too Far? By Dani Rodrik. Washington, D.C
To this debate comes Dani Rodrik, an economist on the faculty of Har- vard's John F. Kennedy School of Government. In his brief and intriguing book, Has Globalization Gone Too Far?,2 he seeks to make the race-to-the- bottom story respectable for those who take economics seriously. Rather than…
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Artikel Jurnal
The Spectrum of Heat-Related Diseases - A Meta-Review
ObjectivesGlobal warming affects health and puts a strain on the healthcare system. Prediction models can forecast healthcare demand and optimize resource allocation. The aim of this study was to identify heat-related diseases and their influencing factors necessary for the development of such a…
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Artikel Jurnal
Liquid foam improves potency and safety of gene therapy vectors
Abstract Interest in gene therapy medicines is intensifying as the first wave of gene-correcting drugs is now reaching patient populations. However, efficacy and safety concerns, laborious manufacturing protocols, and the high cost of the therapeutics are still significant barriers in gene therapy…
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Artikel Jurnal Teks lengkap
In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their expression in circulating T cells to provide…
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Artikel Jurnal Teks lengkap
Effect of Interrupting the Daily Scotophase Period on Laying Hen Performance, Bone Health, Behavior, and Welfare; Part I: Bone Health
Laying hens usually have 16 h of light and 8 h of darkness during egg laying, with eggshell formation primarily occurring during darkness when dietary calcium is lacking, leading to bone calcium resorption and osteoporosis. This study examined how interrupting the dark phase affects bone health in…
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Artikel Jurnal
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour…
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Artikel Jurnal
Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
Current widely used viral and electroporation methods for creating therapeutic cell-based products are complex and expensive. Here, the authors develop targeted mRNA nanocarriers that can transiently program gene expression by simply mixing them with cells, to improve their therapeutic potential.