480 hasil untuk "Basappa"
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Artikel Jurnal Teks lengkap
Reply to: “The non-cytotoxic small molecule NPB does not inhibit BAD phosphorylation and forms colloidal aggregates”
Juga tersedia di: PubMed Central
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Artikel Jurnal Teks lengkap
Thiouracil and triazole conjugate induces autophagy through the downregulation of Wnt/β‐catenin signaling pathway in human breast cancer cells
Autophagy is vital for maintaining cellular homeostasis by breaking down unnecessary organelles and proteins within cells. Its activity varies abnormally in several diseases, including cancer, making it a potential target for therapeutic strategies. The Wnt/β‐catenin signaling pathway significantly…
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Artikel Jurnal Teks lengkap
Treatment options in advanced renal cell carcinoma after first-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors
Targeted therapy for metastatic renal cell carcinoma (mRCC) was introduced a decade ago and since then, a number of therapeutic options have been developed. Vascular endothelial growth factor-targeted therapy is the widely accepted first-line option for mRCC. After progression, treatment in the…
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Artikel Jurnal Teks lengkap
Consideration of population and cultural factors in American Indian/Alaskan Native (AIAN) research
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Artikel Jurnal Teks lengkap
Synthesis, Computational Studies, and Anti-Tuberculosis Activity of Benzoxazines That Act as RAGE Inhibitors
Novel benzoxazines were synthesized by microwave irradiation and tested for their potential binding affinity towards receptors of advanced glycation end products (RAGE). We found that the compound (2-(2-bromophenyl)-6-methyl-2,4-dihydro-1H-benzo[d][1,3]oxazine) (3i) is a lead inhibitor of RAGE…
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Artikel Jurnal
A review on antifungal activities of benzoxazoles against Candida Albicans and SAR studies
Abstract Millions of people are dying due to fungal infections annually across the globe. About 70% of the fungal infections are due to Candida Albicans in the world with mortality rate around 40%. This fungus has the ability to develop resistance upon prolonged exposure to antifungal drugs. To…
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Artikel Jurnal
Cyclization of Activated Methylene Isocyanides with Methyl N(N),N′-Di(tri)substituted Carbamimidothioate: A Novel Entry for the Synthesis of N,1-Aryl-4-tosyl/ethoxycarbonyl-1H-imidazol-5-amines
Abstract Base-induced cyclization of active methylene isocyanides with carbamimidothioates for the synthesis of N,1-aryl-4-tosyl/ethylcarboxy-1H-imidazol-5-amines is reported. The diversity of the reactions is exemplified by using various carbamimidothioates obtained from symmetrical…
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Artikel Jurnal Teks lengkap
Biodegradation of propiconazole by newly isolated Burkholderia sp. strain BBK_9
The isolation of propiconazole (PCZ) degrading bacterium BBK_9 strain was done from paddy soil, and it was identified as Burkholderia sp. based on the morphological characteristics and biochemical properties combined with 16S rRNA gene sequencing analysis. It has been seen that the factors such as…
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Artikel Jurnal Teks lengkap
TFF3 facilitates dormancy of anti-estrogen treated ER+ mammary carcinoma
BACKGROUND: Tumor dormancy is a substantial clinical obstacle in treatment of estrogen receptor positive mammary carcinoma (ER+MC), contributing to drug resistance, metastatic outgrowth, relapse, and consequent mortality. METHODS: Preclinical models mimicking clinical anti-estrogen-induced ER+MC…
Juga tersedia di: DOAJ
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Exploring drought tolerance in wild and traditional olive varieties from the Southern Levant
Local olive germplasm of the southern Levant includes wild populations of var. sylvestris and local traditional cultivars that are thought to be well-adapted to the region’s arid conditions. By controlling water availability, we tested the response of the Barnea cultivar, two local traditional…
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Artikel Jurnal Teks lengkap
Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells
Histone deacetylases (HDACs) are an attractive drug target for the treatment of human breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being used in preclinical and clinical studies. The need to understand the scope of the mode of action of HDACis, as well as the report of the…
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Identification of high confidence genes involved in the manifestation of ventricular septal defect
Abstract Background Ventricular septal defect (VSD) is one of the common congenital heart malformations. Potential risk genes involved in the manifestation of VSD still need to be identified. Methods The whole exome sequencing was performed on 24 congenital heart disease (CHD) subjects, 19 with…
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Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells
Herein, the activity of adamantanyl-tethered-biphenyl amines (ATBAs) as oestrogen receptor alpha (ERα) modulating ligands is reported. Using an ERα competitor assay it was demonstrated that ATBA compound 3-(adamantan-1-yl)-4-methoxy-N-(4-(trifluoromethyl) phenyl) aniline (AMTA) exhibited an…
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Artikel Jurnal Teks lengkap
Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma
The interaction between HER2 and ERα signaling pathways contributes to resistance to anti-estrogen and HER2-targeted therapies, presenting substantial treatment challenges in ER-positive (ER+) HER2-positive (HER2+) mammary carcinoma (MC). Trefoil Factor-3 (TFF3) has been reported to mediate…