7 results for "Benoit Chevalier"

Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium

Miroslaw Zajac; Agathe Lepissier; Elise Dréano et al.

Frontiers in Pharmacology, Vol. 14 · 2023 · English · DOAJ Scopus

Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate (HCO3−) transport into the Airway Surface Liquid (ASL). We investigated the impact of F508del-CFTR correction on HCO3−…

Identification of Keratinocyte Growth Factor as a Target of microRNA-155 in Lung Fibroblasts: Implication in Epithelial-Mesenchymal Interactions

Nicolas Pottier; Thomas Maurin; Benoit Chevalier et al.

PLoS ONE, Vol. 4 No. 8 · 2009 · English · PLOS Scopus

Background: Epithelial-mesenchymal interactions are critical in regulating many aspects of vertebrate embryo development, and for the maintenance of homeostatic equilibrium in adult tissues. The interactions between epithelium and mesenchyme are believed to be mediated by paracrine signals such as…

Also available at: DOAJ

Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons

Iwona Pranke; Laure Bidou; Natacha Martin et al.

ERJ Open Research, Vol. 4 No. 1 · 2018 · English · DOAJ Scopus

Premature termination codons (PTCs) are generally associated with severe forms of genetic diseases. Readthrough of in-frame PTCs using small molecules is a promising therapeutic approach. Nonetheless, the outcome of preclinical studies has been low and variable. Treatment efficacy depends on: 1)…

New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation

Sara Bitam; Ahmad Elbahnsi; Geordie Creste et al.

Scientific Reports, Vol. 11 No. 1 · 2021 · English · DOAJ Scopus

Abstract C407 is a compound that corrects the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein carrying the p.Phe508del (F508del) mutation. We investigated the corrector effect of c407 and its derivatives on F508del-CFTR protein. Molecular docking and dynamics simulations combined…

Author Correction: New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation

Sara Bitam; Ahmad Elbahnsi; Geordie Creste et al.

Scientific Reports, Vol. 11 No. 1 · 2021 · English · DOAJ Scopus

Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR

Iwona Pranke; Valeria Capurro; Benoit Chevalier et al.

Frontiers in Pharmacology, Vol. 16 · 2025 · English · DOAJ Scopus

RationaleRespiratory status of people with Cystic Fibrosis (pwCF) carrying N1303K is improved by Elexacaftor/Tezacaftor/Ivacaftor (ETI) but, contrary to other mutations, the impact on sweat test results is limited.MethodsTo explore this discrepancy, we implemented new sweat gland and respiratory…