22 results for "Burhan Ul Haq"
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Journal Article
Effective Multi-Object of Interest-Based Video Summarization Using Deep Learning: A Smart Technique for User’s Desired Content Optimization
Video summarizing is an essential technique for effective content management, owing to the exponential increase in video data across several domains. However, video analysis to obtain specific content is time-consuming, complicated, and requires high-speed computing power, along with experts, to…
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Journal Article
Comparison of Day Case Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy
Objective: To compare the day case Laparoscopic cholecystectomy with conventional Laparoscopic cholecystectomy in terms of early return to activities and intensity of postoperative pain. Study Design: Randomized control trial (Parallel). Place and Duration of Study: Department of Surgery Pakistan…
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Journal Article
Short-term outcome of metabolic surgery versus intensive medical therapy among obese type 2 diabetics: a quasi-experimental study
Objective: To compare the short-term outcomes of metabolic surgery and intensive medical therapy in the management of diabetes mellitus among obese persons with type 2 diabetes mellitus. Methods: The quasi-experimental study was conducted at the Pakistan Institute of Medical Sciences, Islamabad…
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Journal Article
Cytochrome c as a central regulator of mitochondrial function in cancer metabolism
Abstract Cytochrome c (Cytc) becomes a crucial regulator, determining the fate of cells at the confluence of apoptosis and metabolism. From its primary origin as an electron transporter in the mitochondrial electron transport chain (ETC), Cytc has ascended to a crucial role in apoptosis, triggering…
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Explainable Artificial Intelligence in Medical Image based Diagnosis: A Comprehensive Study
Artificial intelligence (AI) has made remarkable contributions to medical imaging, enhancing the accuracy of the diagnosis and its efficiency; the challenge to the adoption in clinical settings has been the lack of clarity of the deep learning models. Explainable Artificial Intelligence (XAI) is a…
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Journal Article
Targeting mutant p53: a key player in breast cancer pathogenesis and beyond
Abstract The p53 mutation is the most common genetic mutation associated with human neoplasia. TP53 missense mutations, which frequently arise early in breast cancer, are present in over thirty percent of breast tumors. In breast cancer, p53 mutations are linked to a more aggressive course of the…
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Experience of Short Segment Fixation in Thoracolumbar Spine Traumatic Fractures at Tertiary Care Hospital
Objective: To assess the outcome of short-segment posterior fixation in thoracolumbar fractures in terms of reducing kyphosis, the mean hospital stay, pain, intraoperative blood loss, surgical time, and improvement in functional outcome. Study Design: Prospective observational study. Place and…
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Journal Article Full text
Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies
Background and rationale: The incidence and mortality of breast cancer (BC) continue to increase, making it a matter of public health concern worldwide. Despite the various strides made in breast cancer (BC) research, the molecular mechanisms driving its progression remain incompletely understood…
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Journal Article
Experience of Ruptured Thoracolumbar Myelomeningocele Repair Under Local Anesthesia in Neonates
Objective: To see the efficacy of surgical repair of ruptured thoracolumbar myelomeningocele under local anesthesia. Study Design: Quasi experimental study. Place and Duration of Study: Neurosurgery center, CMH Rawalpindi, Pakistan from Jun 2022 to Jan 2024. Methodology: All the patients were…
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Journal Article Full text
Outcomes of Bolus Dose Furosemide Versus Continuous Infusion in Patients With Acute Decompensated Left Ventricular Failure and Atrial Fibrillation
BACKGROUND: This prospective, randomized trial aimed to compare the efficacy and safety of different intravenous diuretic regimens in acute decompensated heart failure (ADHF) patients. METHODS: ADHF patients were enrolled and randomized into three groups: continuous intravenous furosemide infusion…
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Journal Article
SmartBin: An Approach to Smart Living Community Using IoT Techniques and Tools
Nowadays, individuals are getting steadily dynamic in achieving the possible ways to clean their environment. The concerned teams have initiated other developments to build tidiness. Previously, prior data on filling the trash container was required, which cautions and sends cautioning messages to…
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Journal Article
Warfarin-Induced Coagulopathy: Is Digoxin the Culprit?
Warfarin is a notorious drug for drug interactions. Certain situations like severe Mitral Stenosis and Atrial Fibrillation still necessitate the use of warfarin, which increases bleeding risk. Here, we describe a case of warfarin-induced coagulopathy which may have occurred due to unusual…
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Artificial Intelligence–Driven Imaging Advances in Lung Fibrosis: A Comprehensive Review
Lung fibrosis is a chronic and progressive illness where there is pathologic tissue scarring, which affects lung architecture and respiratory organ functioning. It is caused by several factors, including idiopathic pulmonary fibrosis (IPF), radiation-related injury, tumour-related fibrosis, and…
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Journal Article
Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology
Cancer represents a significant global health and economic burden due to its high mortality rates. While effective in some instances, traditional chemotherapy often falls short of entirely eradicating various types of cancer. It can cause severe side effects due to harm to healthy cells. Two…
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Journal Article
The Impacts of Ethical Hacking and its Security Mechanisms
Hacking is a typical method for breaching personal and confidential information. As a result, hacking is also known as infiltration. Intrusions, on the other hand, were not always recognized as theft and were employed for productive purposes. A person or corporation that does ethical hacking and…
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Journal Article
Multi-Defect Classification in Oranges Using YOLOv8, YOLO11, and YOLOv8m: A Comparative Study
Orange farming is among the most economically significant agricultural activities in the world, with the crop feeding global markets and supporting millions of smallholder livelihoods. Yet despite that importance, quality grading at the post-harvest stage still depends heavily on manual inspection…
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Journal Article
Targeting p53 misfolding conundrum by stabilizing agents and their analogs in breast cancer therapy: a comprehensive computational analysis
Cancer continues to be a major global public health concern and one of the foremost causes of death. Delays in the diagnosis and cure may cause an increase in advanced stage disease and mortality. The most common cancer found in women currently is breast carcinoma. Breast carcinoma has surpassed…
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Journal Article
Exploring HMMR as a therapeutic frontier in breast cancer treatment, its interaction with various cell cycle genes, and targeting its overexpression through specific inhibitors
Among women, breast carcinoma is one of the most complex cancers, with one of the highest death rates worldwide. There have been significant improvements in treatment methods, but its early detection still remains an issue to be resolved. This study explores the multifaceted function of…
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Journal Article
E-Healthcare Using Block Chain Technology and Cryptographic Techniques: A Review
The potential of information technology has influenced the efficiency and quality of healthcare worldwide. Currently, several republics are incorporating electronic health records (EHRs). Due to reluctance of technological adaptation & implementational complexities, electronic health record systems…