3 results for "Chun-Rong Wang"
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Journal Article
Progress study on the mechanism of CAG repeats dynamic mutation in polyQ disease
Polyglutamine (polyQ) disease is a group of neurodegenerative disorders caused by abnormal expansion of CAG repeats within coding regions of certain causative genes, which are translated into a series of abnormally expanded polyQ tracts causing cytotoxicity. So far, nine diseases caused by expanded…
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Journal Article
In Vitro and In Vivo Studies of Non-Platinum-Based Halogenated Compounds as Potent Antitumor Agents for Natural Targeted Chemotherapy of Cancers
Based on a molecular-mechanism-based anticancer drug discovery program enabled by an innovative femtomedicine approach, we have found a previously unknown class of non-platinum-based halogenated molecules (called FMD compounds) as potent antitumor agents for effective treatment of cancers. Here, we…
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Journal Article
Influence of fracturing fluid rheology on proppant transport and elbow erosion: A comparative CFD-DEM study
To enable the precise prediction and control of erosion in hydraulic fracturing pipelines, this study employs a CFD-DEM method coupled with a wear model to quantitatively analyze the influence of shear-thinning fracturing fluids on proppant transport and elbow erosion. The study reveals a critical…