11 results for "Daniel Benítez-Ribas"

Therapeutic Potential of Tolerogenic Dendritic Cells in IBD: From Animal Models to Clinical Application

Raquel Cabezón; Daniel Benítez-Ribas

Clinical and Developmental Immunology, Vol. 2013 · 2013 · English · DOAJ

The gut mucosa undergoes continuous antigenic exposure from food antigens, commensal flora derived ligands, and pathogens. This constant stimulation results in controlled inflammatory responses that are effectively suppressed by multiple factors. This tight regulation, necessary to maintain…

Priming by Chemokines Restricts Lateral Mobility of the Adhesion Receptor LFA-1 and Restores Adhesion to ICAM-1 Nano-Aggregates on Human Mature Dendritic Cells

Kyra J. E. Borgman; Thomas S. van Zanten; Carlo Manzo et al.

PLoS ONE, Vol. 9 No. 6 · 2014 · English · PLOS Scopus

LFA-1 is a leukocyte specific β2 integrin that plays a major role in regulating adhesion and migration of different immune cells. Recent data suggest that LFA-1 on mature dendritic cells (mDCs) may function as a chemokine-inducible anchor during homing of DCs through the afferent lymphatics into…

Also available at: DOAJ

Novel Tumor-Targeted Self-Nanostructured and Compartmentalized Water-in-Oil-in-Water Polyurethane-Polyurea Nanocapsules for Cancer Theragnosis

Joaquín Bonelli; María Velasco-de Andrés; Neus Isidro et al.

Pharmaceutics, Vol. 15 No. 1 · 2022 · English · DOAJ Scopus

Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The…

Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer

Mercedes Marín-Aguilera; Natalia Jiménez; Òscar Reig et al.

Cells, Vol. 9 No. 1 · 2020 · English · DOAJ Scopus

Androgen receptor (AR) signaling remains crucial in castration-resistant prostate cancer (CRPC). Since it is also essential in immune cells, we studied whether the expression of AR full-length (ARFL) and its splicing variant ARV7 in peripheral blood mononuclear cells (PBMC) predicts systemic…

Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias

Mercedes Guerrero-Murillo; Aina Rill-Hinarejos; Juan L. Trincado et al.

Cell Reports Medicine, Vol. 6 No. 3 · 2025 · English · DOAJ Scopus

Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias

Mercedes Guerrero-Murillo; Aina Rill-Hinarejos; Juan L. Trincado et al.

Cell Reports Medicine, Vol. 5 No. 11 · 2024 · English · DOAJ Scopus

Summary: The impact of phenotypic, clonal, and functional heterogeneity of chimeric antigen receptor (CAR)-T cells on clinical outcome remains understudied. Here, we integrate clonal kinetics with transcriptomic heterogeneity resolved by single-cell omics to interrogate cellular dynamics of…

Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter’s Transformation

Valentín Ortiz-Maldonado; Gerard Frigola; Marta Español-Rego et al.

Frontiers in Oncology, Vol. 12 · 2022 · English · DOAJ Scopus

CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy…

A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes

Leire Pedrosa; Carles Foguet; Helena Oliveres et al.

Frontiers in Immunology, Vol. 13 · 2022 · English · DOAJ Scopus

Existing immune signatures and tumor mutational burden have only modest predictive capacity for the efficacy of immune check point inhibitors. In this study, we developed an immune-metabolic signature suitable for personalized ICI therapies. A classifier using an immune-metabolic signature…

Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

Maria Castella; Miguel Caballero-Baños; Valentín Ortiz-Maldonado et al.

Frontiers in Immunology, Vol. 11 · 2020 · English · DOAJ Scopus

Development of semi-automated devices that can reduce the hands-on time and standardize the production of clinical-grade CAR T-cells, such as CliniMACS Prodigy from Miltenyi, is key to facilitate the development of CAR T-cell therapies, especially in academic institutions. However, the feasibility…

Efficacy and safety of the academic anti‐CD19 chimeric antigen receptor T‐cell product varnimcabtagene autoleucel for the treatment of relapsed/refractory follicular lymphoma

Núria Martínez‐Cibrián; Valentín Ortiz‐Maldonado; Marta Español‐Rego et al.

HemaSphere, Vol. 9 No. 9 · 2025 · English · DOAJ Scopus

Abstract We report the outcome of patients with relapsed/refractory (R/R) follicular lymphoma (FL) treated with varnimcabtagene autoleucel (var‐cel), an academic anti‐CD19 chimeric antigen receptor (CAR) T‐cell product. Patients were included in the CART19‐BE‐01 clinical trial and a compassionate…