8 hasil untuk "Daniela Calini"

muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data

Helena Lucia Crowell; Charlotte Soneson; Pierre‐Luc Germain dkk.

Nature Communications · 2020 · Inggris · OpenAlex Scopus

Single-cell RNA sequencing (scRNA-seq) has become an empowering technology to profile the transcriptomes of individual cells on a large scale. Early analyses of differential expression have aimed at identifying differences between subpopulations to identify subpopulation markers. More generally…

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Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology

Pallavi Gaur; Julien Bryois; Daniela Calini dkk.

Nature Communications, Vol. 16 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Alzheimer’s disease, the leading cause of dementia in the elderly, is a neurodegenerative disorder that has been studied to uncover therapeutic pathways through its molecular and cellular hallmarks. Here, we present a comprehensive investigation of cellular heterogeneity from the temporal…

CellMixS: quantifying and visualizing batch effects in single-cell RNA-seq data

Almut Lütge; Joanna Zyprych-Walczak; Urszula Brykczynska Kunzmann dkk.

Life Science Alliance, Vol. 4 No. 6 · 2021 · Inggris · DOAJ Scopus

A systematic comparison of batch effect metrics for single cell data is performed. The new cell-specific mixing score from the R/Bioconductor CellMixS package performs well across various tasks. A key challenge in single-cell RNA-sequencing (scRNA-seq) data analysis is batch effects that can…

Enrichment of Glial Cells From Human Post-mortem Tissue for Transcriptome and Proteome Analysis Using Immunopanning

Anna Nolle; Irene van Dijken; Ciril M. Waelti dkk.

Frontiers in Cellular Neuroscience, Vol. 15 · 2021 · Inggris · DOAJ Scopus

Glia cells have a crucial role in the central nervous system and are involved in the majority of neurological diseases. While glia isolation techniques are well established for rodent brain, only recent advances in isolating glial cells from human brain enabled analyses of human-specific glial-cell…

Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders

Julien Bryois; Daniela Calini; Will Macnair dkk.

Nature Neuroscience · 2022 · Inggris · OpenAlex Scopus

TARDBP mutations in a cohort of Italian patients with Parkinson’s disease and atypical parkinsonisms

Cinzia Tiloca; Stefano Goldwurm; Narghes Calcagno dkk.

Frontiers in Aging Neuroscience, Vol. 14 · 2022 · Inggris · DOAJ Scopus

BackgroundAggregates of TAR DNA-binding protein of 43 kDa (TDP-43) represent the pathological hallmark of most amyotrophic lateral sclerosis (ALS) and of nearly 50% of frontotemporal dementia (FTD) cases but were also observed to occur as secondary neuropathology in the nervous tissue of patients…

T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis

Ivan Jelcic; Reza Naghavian; Imran Fanaswala dkk.

Cell Reports Medicine, Vol. 6 No. 3 · 2025 · Inggris · DOAJ Scopus

Summary: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Self-peptide-dependent autoproliferation (AP) of B and T cells is a key mechanism in MS. Here, we show that pro-inflammatory B-T cell-enriched cell clusters (BTECs) form during AP and mirror features of a…