67 results for "David Atkinson"
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Journal Article
Ballad and Street Literature Printing in Petticoat Lane, 1740s-1760s
The strongest evidence for ballads in eighteenth-century England lies in the considerable numbers of printed broadsides and chapbooks that survive from the period. The printers of ballads also issued prose works aimed at the same street literature market. This paper provides a glimpse into the…
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Journal Article Full text
Agriculture - reconciling ancient tensions
Decision-making in agriculture has tended to be driven by factors other than environmental concerns. This may be changing, and perhaps the emphases of the two creation accounts in Genesis (responsible management or 'dominion', and active care) may become more important. The paper examines a number…
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Journal Article
Immuno-electron cryo-microscopy imaging reveals a looped topology of apoB at the surface of human LDL[S]
A single copy of apoB is the sole protein component of human LDL. ApoB is crucial for LDL particle stabilization and is the ligand for LDL receptor, through which cholesterol is delivered to cells. Dysregulation of the pathways of LDL metabolism is well documented in the pathophysiology of…
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Book
The Anglo-Scottish Ballad and its Imaginary Contexts
This is the first book to combine contemporary debates in ballad studies with the insights of modern textual scholarship. Just like canonical literature and music, the ballad should not be seen as a uniquely authentic item inextricably tied to a documented source, but rather as an unstable…
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Journal Article
Human LDL core cholesterol ester packing: three-dimensional image reconstruction and SAXS simulation studies
Human LDL undergoes a reversible thermal order-disorder phase transition associated with the cholesterol ester packing in the lipid core. Structural changes associated with this phase transition have been shown to affect the resistance of LDL to oxidation in vitro studies. Previous electron…
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Journal Article
Social network analysis of rural medical networks after medical school immersion in a rural clinical school
Abstract Background The impact of new medical graduates on the social dimensions of the rural medical workforce is yet to be examined. Social Network Analysis (SNA) is able to visualize and measure these dimensions. We apply this method to examine the workforce characteristics of graduates from a…
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Journal Article
Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity
ApoA-I activates LCAT that converts lipoprotein cholesterol to cholesteryl ester (CE). Molecular dynamic simulations suggested earlier that helices 5 of two antiparallel apoA-I molecules on discoidal HDL form an amphipathic tunnel for migration of acyl chains and unesterified cholesterol to the…
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Journal Article
Binding of human apoA-I[K107del] variant to TG-rich particles: implications for mechanisms underlying hypertriglyceridemia
We found earlier that apoA-I variants that induced hypertriglyceridemia (HTG) in mice had increased affinity to TG-rich lipoproteins and thereby impaired their catabolism. Here, we tested whether a naturally occurring human apoA-I mutation, Lys107del, associated with HTG also promotes apoA-I…
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Journal Article
Probing the C-terminal domain of lipid-free apoA-I demonstrates the vital role of the H10B sequence repeat in HDL formation
apoA-I plays important structural and functional roles in reverse cholesterol transport. We have described the molecular structure of the N-terminal domain, Δ(185-243) by X-ray crystallography. To understand the role of the C-terminal domain, constructs with sequential elongation of Δ(185-243), by…
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Journal Article
N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis
ApoA-I and ABCA1 play important roles in nascent HDL (nHDL) biogenesis, the first step in the pathway of reverse cholesterol transport that protects against cardiovascular disease. On the basis of the crystal structure of a C-terminally truncated form of apoA-I[Δ(185-243)] determined in our…
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Journal Article Full text
Combined effects of water temperature, grazing snails and terrestrial herbivores on leaf decomposition in urban streams
The decomposition of organic matter in freshwaters, such as leaf litter, can affect global nutrient (e.g., carbon) cycling. This process can be influenced by fast urbanization through increased water temperature, reduced aquatic diversity and changed leaf litter quality traits. In this study, we…
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Why validation is not enough: Setting the scene for the implementation of the Kimberley Mum's Mood Scale.
BackgroundThe two part Kimberley Mum's Mood Scale (KMMS) has been developed and validated as a culturally appropriate perinatal depression and anxiety screening tool for Aboriginal women living in the sparsely populated Kimberley region of North West Australia. As part of implementation aspects of…
Also available at: PLOS
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Journal Article
Surface behavior of apolipoprotein A-I and its deletion mutants at model lipoprotein interfaces
Apolipoprotein A-I (apoA-I) has a great conformational flexibility to exist in lipid-free, lipid-poor, and lipid-bound states during lipid metabolism. To address the lipid binding and the dynamic desorption behavior of apoA-I at lipoprotein surfaces, apoA-I, Δ(185-243)apoA-I, and…
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Journal Article
Pregnancy intentions in a group of remote-dwelling Australian Aboriginal women: a qualitative exploration of formation, expression and implications for clinical practice
Abstract Background Unintended pregnancies are associated with poorer obstetric outcomes and are sometimes measured at a population level as a surrogate marker for reproductive autonomy and access to health services, including contraception. Aboriginal Australians face many disparities in health…
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Journal Article
Generative AI and LLMs in industry: a text-mining analysis and critical evaluation of guidelines and policy statements across 14 industrial sectors
Abstract The rise of Generative AI (GAI) and Large Language Models (LLMs) has transformed industrial landscapes, offering unprecedented opportunities for efficiency and innovation while raising critical ethical, regulatory, and operational challenges. Despite growing adoption across sectors, little…