17 hasil untuk "Edgar Garcia-Rill"

The Critical Role of Intrinsic Membrane Oscillations

Sang-Hun Lee; Francisco J. Urbano; Edgar Garcia-Rill

Neurosignals, Vol. 26 No. 1 · 2018 · Inggris · DOAJ Scopus

Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These…

Pedunculopontine arousal system physiology – Implications for insomnia

Edgar Garcia-Rill; Brennon Luster; Susan Mahaffey dkk.

Sleep Science, Vol. 8 No. 2 · 2015 · Inggris · DOAJ Scopus

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency…

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Pedunculopontine arousal system physiology–Implications for schizophrenia

Edgar Garcia-Rill; Stasia D'Onofrio; Susan Mahaffey dkk.

Sleep Science, Vol. 08 No. 02 · 2015 · Inggris · DOAJ Scopus

Schizophrenia is characterized by major sleep/wake disturbances including increased vigi-lance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal-related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is…

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Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)

Edgar Garcia-Rill; Brennon Luster; Stasia D'Onofrio dkk.

Sleep Science, Vol. 08 No. 03 · 2015 · Inggris · DOAJ Scopus

This review describes the wake/sleep symptoms present in Parkinson's disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for…

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Modafinil Abrogates Methamphetamine-Induced Neuroinflammation and Apoptotic Effects in the Mouse Striatum

Mariana Raineri; Betina Gonzalez; Belen Goitia dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine dependence. The aim of the present study was to…

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Pedunculopontine Gamma Band Activity and Development

Edgar Garcia-Rill; Brennon Luster; Susan Mahaffey dkk.

Brain Sciences, Vol. 5 No. 4 · 2015 · Inggris · DOAJ Scopus

This review highlights the most important discovery in the reticular activating system in the last 10 years, the manifestation of gamma band activity in cells of the reticular activating system (RAS), especially in the pedunculopontine nucleus, which is in charge of waking and rapid eye movement…

Proteomic measures of gamma oscillations

Stephanie D. Byrum; Charity L. Washam; Alan J. Tackett dkk.

Heliyon, Vol. 5 No. 8 · 2019 · Inggris · DOAJ Scopus

Background: Gamma oscillations serve complex processes, and the first stage of their generation is the reticular activating system (RAS), which mediates the gamma-activity states of waking and paradoxical sleep. We studied whether the pedunculopontine nucleus (PPN), part of the RAS in which every…

Psychostimulant-Induced Testicular Toxicity in Mice: Evidence of Cocaine and Caffeine Effects on the Local Dopaminergic System

Candela R. González; Betina González; María E. Matzkin dkk.

PLOS ONE, Vol. 10 No. 11 · 2015 · Inggris · PLOS Scopus

Several organ systems can be affected by psychostimulant toxicity. However, there is not sufficient evidence about the impact of psychostimulant intake on testicular physiology and catecholaminergic systems. The aim of the present study was to further explore potential toxic consequences of chronic…

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Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Tuhin Virmani; Lakshmi Pillai; Reid D. Landes dkk.

Annals of Clinical and Translational Neurology, Vol. 13 No. 5 · 2026 · Inggris · DOAJ Scopus

ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil…

Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus

Edgar Garcia-Rill; Alan J. Tackett; Stephanie D. Byrum dkk.

Brain Sciences, Vol. 9 No. 3 · 2019 · Inggris · DOAJ Scopus

Our discovery of low-threshold stimulation-induced locomotion in the pedunculopontine nucleus (PPN) led to the clinical use of deep brain stimulation (DBS) for the treatment of disorders such as Parkinson’s disease (PD) that manifest gait and postural disorders. Three additional major discoveries…

Pedunculopontine arousal system physiology—Effects of psychostimulant abuse

Francisco J. Urbano; Verónica Bisagno; Betina González dkk.

Sleep Science, Vol. 8 No. 3 · 2015 · Inggris · DOAJ Scopus

This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to…

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