106 hasil untuk "Francisca Mutapi"
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Artikel Jurnal
Putting the treatment of paediatric schistosomiasis into context
Abstract Despite increased international efforts to control schistosomiasis using preventive chemotherapy, several challenges still exist in reaching the target populations. Until recently, preschool-aged children had been excluded from the recommended target population for mass drug…
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Artikel Jurnal Teks lengkap
Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models.
Schistosomiasis control is heavily reliant on the drug praziquantel (PZQ), which is used as preventive chemotherapy as part of national helminth control strategies. Given the heavy reliance on PZQ for mass drug administration, there has been considerable research on the potential of parasites…
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Artikel Jurnal
Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment
Schistosomiasis is a parasitic disease infecting over 236 million people annually, with the majority affected residing on the African continent. Control of this disease is reliant on the drug praziquantel (PZQ), with treatment success dependent on an individual reaching PZQ concentrations lethal to…
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Artikel Jurnal Teks lengkap
The human immunome in the post-schistosomiasis mass drug administration era.
Helminths have co-evolved with humans and developed sophisticated mechanisms to manipulate the host immune system, allowing them to persist for years. During chronic disease, helminths typically shift immune responses toward a Th2 profile-supporting antibody production and tissue repair-while…
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Artikel Jurnal
Mainstreaming female genital schistosomiasis to ensure it is not neglected among the neglected tropical diseases
Female genital schistosomiasis (FGS) is a neglected manifestation of Schistosoma haematobium infection, affecting an estimated 56 million women in sub-Saharan Africa. It is characterized by lesions in the genital tract, leading to symptoms like pain, infertility and an increased risk of HIV…
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Artikel Jurnal
The big picture
Affecting 110 million African children, schistosomiasis control demands an urgent shift from drug treatments to permanent transmission interruption. This requires pairing paediatric drug formulations and new interventions including any new vaccines with locally-relevant multisectoral policy, WASH…
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Artikel Jurnal
What does equitable global health research and delivery look like? Tackling Infections to Benefit Africa (TIBA) partnership as a case study
There is a current global push to identify and implement best practice for delivering maximum impact from development research in low-income and middle-income countries. Here, we describe a model of research and capacity building that challenges traditional approaches taken by western funders in…
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Artikel Jurnal Teks lengkap
Unlocking the blueprint to eliminating neglected tropical diseases: A review of efforts in 50 countries that have eliminated at least 1 NTD.
BackgroundNeglected tropical diseases (NTDs) are a group of 21 diseases affecting approximately 1.5 billion people globally. Significant progress has been made in their control: by March 2024, 50 countries had eliminated at least one NTD, with 13 of these countries eliminating at least two. Togo…
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Artikel Jurnal
Human Schistosome Infection and Allergic Sensitisation
Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to allergic sensitisation. However, helminth…
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Artikel Jurnal
A narrative review of heterogeneity in SARS-CoV-2 infection outcomes and vaccine efficacy: strategizing pandemic preparedness in Africa
Disease epidemiology during the COVID-19 pandemic differed greatly across the globe. In contrast to early pandemic predictions, Africa recorded the fewest SARS-CoV-2 related hospitalizations and deaths. Hypotheses proposed to explain this paradox include underreporting, age demographics, climate…
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Artikel Jurnal
Coinfections and comorbidities in African health systems: At the interface of infectious and noninfectious diseases.
There is a disease epidemiological transition occurring in Africa, with increasing incidence of noninfectious diseases, superimposed on a health system historically geared more toward the management of communicable diseases. The persistence and sometimes emergence of new pathogens allows for the…
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Artikel Jurnal Teks lengkap
Paediatric schistosomiasis: What we know and what we need to know.
Schistosomiasis affects over 200 million people worldwide, most of whom are children. Research and control strategies directed at preschool-aged children (PSAC), i.e., ≤5 years old, have lagged behind those in older children and adults. With the recent WHO revision of the schistosomiasis treatment…
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Artikel Jurnal
Association of schistosomiasis and risk of prostate cancer development in residents of Murehwa rural community, Zimbabwe
Abstract Background Prostatic male genital schistosomiasis and prostate cancer co-existence cases are uncommon however, some studies have indicated that schistosomiasis may trigger development of prostate cancer regardless of age. Schistosomiasis is a public health problem in sub-Saharan Africa and…