38 hasil untuk "Han, Li-li"
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Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson’s disease
BACKGROUND: There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson’s disease (PD). The present study was conducted with aims of exploring the role of miR-96 in…
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Impact of acute and chronic stress hormone on male albino rat brain
The present investigation aimed to evaluate the acute and chronic effect of stress (stress hormone) in male albino rat brain. Nor-epinephrine was used for the treatment and saline used for the control. Nor-epinephrine was dissolved in the saline and administered orally to the rats. Following…
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Exploring the relationship between co-abundance of gut microbiota and novel metabolic pathways in different subtypes of irritable bowel syndrome: insights from the American Gut Project
BACKGROUND: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder with an unclear etiology. Recent studies have underscored the association between alterations in the gut microbiome and the pathogenesis of IBS. However, limited knowledge exists regarding the…
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miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2
Improving the long-term survival of patients with hepatocellular carcinoma (HCC) remains a challenge due to metastasis and recurrence. In this study, we demonstrate that the overexpression of miR-103 in HCC cells promotes epithelial-mesenchymal transition (EMT), and is associated with an enhanced…
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A Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Coexistence of the JAK2V617F Clone
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Application of virtual simulation experiments in physiological experimental teaching
Objective To evaluate the teaching effects of physiological virtual simulation experiments. Methods In spring semester of 2020, virtual simulation experiments were applied in the physiological experimental course in Peking University Health Science Center. The teaching effect was evaluated…
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Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression
Abstract Objective The comorbid relationship between migraine and depression has been well recognized, but its underlying pathophysiology is unclear. Here, we aimed to explore the structural changes of the amygdala and the abnormal functional connectivity of the centromedial amygdala (CMA) in…
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Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy
Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide and accounts for approximately one-third of all malignancies. In the past decade, advances have been made to improve the prognosis of HCC, including improvement in the clinical diagnosis of early-stage HCC using molecular…
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Prognostic role of ABO blood group in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization
BACKGROUND: The association of ABO blood group with prognosis of several malignancies has been established. However, its role in hepatocellular carcinoma (HCC) remains unclear. PATIENTS AND METHODS: In this study, we investigated the prognostic role of ABO blood group in unresectable HCC patients…
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Incidence of central nervous system metastases in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer treated with trastuzumab: A meta-analysis
This study aimed to estimate the incidence of central nervous system (CNS) metastases in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) treated with trastuzumab. Studies were identified through a literature search of electronic databases…
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Genetic and functional diversity of ubiquitous DNA viruses in selected Chinese agricultural soils
Viral community structures in complex agricultural soils are largely unknown. Electron microscopy and viromic analyses were conducted on six typical Chinese agricultural soil samples. Tailed bacteriophages, spherical and filamentous viral particles were identified by the morphological analysis…
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"Synthesis and photochromic behavior of spiro-pyran functionalized styrene-butadiene block copolymer"
Using active anionic solution polyme-rization technology, a styrene-butadiene block copolymer (PVPDMS-b-PB) functionalized with silicon-hydride groups was synthesized via feed distribution method. Gel permeation chromatography was employed to analyze the number-average molecular weight and…
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Acupuncture at local and distant points for tinnitus: study protocol for a randomized controlled trial
BACKGROUND: Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as…
Juga tersedia di: DOAJ
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Ammonia oxidizers offset acidification stress via adaptive substrate affinity in aquatic ecosystems
Ammonia oxidation, a critical nitrogen cycle process, exhibits contradictory responses to aquatic acidification, and the underlying mechanism remains unresolved. Here, through pH manipulation experiments across diverse ecosystems and with a model ammonia-oxidizing archaea species, Nitrosopumilus…
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Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser(552)
Given the fundamental role of β-catenin signaling in intestinal epithelial cell proliferation and the growth-promoting function of protein kinase D1 (PKD1) in these cells, we hypothesized that PKDs mediate cross talk with β-catenin signaling. The results presented here provide several lines of…
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Nitrogen fixation and diazotroph diversity in groundwater systems
Biological nitrogen fixation (BNF), the conversion of N(2) into bioavailable nitrogen (N), is the main process for replenishing N loss in the biosphere. However, BNF in groundwater systems remains poorly understood. In this study, we examined the activity, abundance, and community composition of…
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Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China
…found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China. However, it is still unclear why there is such geographical and population variation in KSHV distribution in…
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MiR-195 suppresses the metastasis and epithelial–mesenchymal transition of hepatocellular carcinoma by inhibiting YAP
MiR-195, a novel cancer-related microRNA, was previously reported to play an important role in many malignancies. This study aimed to investigate the role of miR-195 mediated epithelial–mesenchymal transition (EMT) and the progression of hepatocellular carcinoma (HCC) as well as the underlying…
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Research Progress on Structure-Activity Relationship of 1,8-Naphthalimide DNA Chimeras Against Tumor
The development of 1,8-naphthalimide derivatives as cell probes, DNA targeting agents, and anti-tumor drugs is one of the research hotspots in the field of medicine. Naphthalimide compounds are a kind of DNA embedder, which can change the topological structure of DNA by embedding in the middle of…