71 results for "I-Ching Sam"

CURRENT ISSUES FACING THE INTRODUCTION OF HUMAN PAPILLOMAVIRUS VACCINE IN MALAYSIA

I-Ching Sam; Wong Li Ping

Malaysian Family Physician, Vol. 2 No. 2 · 2007 · English · DOAJ Scopus

Certain human papillomavirus (HPV) types are strongly associated with cervical cancer. Recently-described effective vaccines against these HPV types represent a great medical breakthrough in preventing cervical cancer. In Malaysia, the vaccine has just received regulatory approval. We are likely to…

The Autophagic Machinery in Enterovirus Infection

Jeffrey K. F. Lai; I-Ching Sam; Yoke Fun Chan

Viruses, Vol. 8 No. 2 · 2016 · English · DOAJ Scopus

The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68. They cause a wide variety of diseases, ranging from mild to severe life-threatening diseases. Currently, no effective vaccine is…

Perspectives of vector management in the control and elimination of vector-borne zoonoses

Meng Li Wong; Zulhisham Zulzahrin; Indra Vythilingam et al.

Frontiers in Microbiology, Vol. 14 · 2023 · English · DOAJ Scopus

The complex transmission profiles of vector-borne zoonoses (VZB) and vector-borne infections with animal reservoirs (VBIAR) complicate efforts to break the transmission circuit of these infections. To control and eliminate VZB and VBIAR, insecticide application may not be conducted easily in all…

Mycobacterium tuberculosis and Rifampin Resistance, United Kingdom

I-Ching Sam; Francis Drobniewski; Philip More et al.

Emerging Infectious Diseases, Vol. 12 No. 5 · 2006 · English · DOAJ Scopus

The United Kingdom Health Protection Agency Mycobacterium Reference Unit offers a national "Fastrack" molecular service for detecting Mycobacterium tuberculosis complex (MTBC) and rifampin resistance by using the INNO-LiPA Rif.TB assay. We analyzed the service in a routine, nontrial context of…

Antigenic Variation of East/Central/South African and Asian Chikungunya Virus Genotypes in Neutralization by Immune Sera.

Chong-Long Chua; I-Ching Sam; Andres Merits et al.

PLoS Neglected Tropical Diseases, Vol. 10 No. 8 · 2016 · English · DOAJ Scopus

BackgroundChikungunya virus (CHIKV) is a re-emerging mosquito-borne virus which causes epidemics of fever, severe joint pain and rash. Between 2005 and 2010, the East/Central/South African (ECSA) genotype was responsible for global explosive outbreaks across India, the Indian Ocean and Southeast…

Also available at: PLOS

The neutralizing role of IgM during early Chikungunya virus infection

Chong-Long Chua; I-Ching Sam; Chun-Wei Chiam et al.

PLOS ONE, Vol. 12 No. 2 · 2017 · English · PLOS Scopus

The antibody isotype IgM appears earlier than IgG, within days of onset of symptoms, and is important during the early stages of the adaptive immune response. Little is known about the functional role of IgM during infection with chikungunya virus (CHIKV), a recently reemerging arbovirus that has…

Also available at: DOAJ

Immunodominant IgM and IgG Epitopes Recognized by Antibodies Induced in Enterovirus A71-Associated Hand, Foot and Mouth Disease Patients

Kam Leng Aw-Yong; I-Ching Sam; Mia Tuang Koh et al.

PLOS ONE, Vol. 11 No. 11 · 2016 · English · PLOS Scopus

Enterovirus A71 (EV-A71) is one of the main causative agents of hand, foot and mouth disease (HFMD). Unlike other enteroviruses that cause HFMD, EV-A71 is more frequently associated with severe neurological complications and fatality. To date, no effective licensed antivirals are available to…

Also available at: DOAJ

Reemergence of Endemic Chikungunya, Malaysia

Sazaly AbuBakar; I-Ching Sam; Pooi-Fong Wong et al.

Emerging Infectious Diseases, Vol. 13 No. 1 · 2007 · English · DOAJ Scopus

Chikungunya virus infection recently reemerged in Malaysia after 7 years of nondetection. Genomic sequences of recovered isolates were highly similar to those of Malaysian isolates from the 1998 outbreak. The reemergence of the infection is not part of the epidemics in other Indian Ocean countries…

New Paradigms for Virus Detection, Surveillance and Control of Zika Virus Vectors in the Settings of Southeast Asia

Indra Vythilingam; Jamal I-Ching Sam; Yoke-Fun Chan et al.

Frontiers in Microbiology, Vol. 7 · 2016 · English · DOAJ Scopus

Zika virus (ZIKV) has now become a global public health concern. The vectors for ZIKV are Aedes aegypti and Aedes albopictus. Both these mosquitoes are predominant in Southeast Asia and are also responsible for the spread of other arboviral diseases like dengue virus (DENV) and chikungunya virus…

Enterovirus 71 Outbreak, Brunei

Sazaly AbuBakar; I-Ching Sam; Jaliha Yusof et al.

Emerging Infectious Diseases, Vol. 15 No. 1 · 2009 · English · DOAJ Scopus

Enterovirus 71 (EV71) outbreaks occur periodically in the Asia-Pacific region. In 2006, Brunei reported its first major outbreak of EV71 infections, associated with fatalities from neurologic complications. Isolated EV71 strains formed a distinct lineage with low diversity within subgenogroup B5…

Enterovirus A71 DNA-Launched Infectious Clone as a Robust Reverse Genetic Tool

Chee Wah Tan; Han Kang Tee; Michelle Hui Pheng Lee et al.

PLOS ONE, Vol. 11 No. 9 · 2016 · English · PLOS Scopus

Enterovirus A71 (EV-A71) causes major outbreaks of hand, foot and mouth disease, and is occasionally associated with neurological complications and death in children. Reverse genetics is widely used in the field of virology for functional study of viral genes. For EV-A71, such tools are limited to…

Also available at: DOAJ

Nationwide Survey of Knowledge and Health Beliefs regarding Human Papillomavirus among HPV-Vaccinated Female Students in Malaysia

Li Ping Wong; Raja Nur Amalina Raja Muhammad Yusoff; Zobaida Edib et al.

PLOS ONE, Vol. 11 No. 9 · 2016 · English · PLOS Scopus

The National HPV Immunization Programme, which offers free human papillomavirus (HPV) vaccines to teenaged female students, was launched in Malaysia in 2010. HPV vaccination paired with adequate knowledge about HPV infection provides the best protection against cervical cancer. To identify the…

Also available at: DOAJ

Humoral and T Cell Immune Responses against SARS-CoV-2 after Primary and Homologous or Heterologous Booster Vaccinations and Breakthrough Infection: A Longitudinal Cohort Study in Malaysia

Jolene Yin Ling Fu; Muhammad Harith Pukhari; Maria Kahar Bador et al.

Viruses, Vol. 15 No. 4 · 2023 · English · DOAJ Scopus

Vaccine efficacy against SARS-CoV-2 could be compromised by the emergence of SARS-CoV-2 variants and it is important to study how it impacts the booster vaccination regime. We investigated the humoral and T cell responses longitudinally in vaccinated uninfected (n = 25) and post-COVID-19…

Comparative Evaluation of a Standard M10 Assay with Xpert Xpress for the Rapid Molecular Diagnosis of SARS-CoV-2, Influenza A/B Virus, and Respiratory Syncytial Virus

Azwani Abdullah; I-Ching Sam; Yin Jie Ong et al.

Diagnostics, Vol. 13 No. 23 · 2023 · English · DOAJ Scopus

SARS-CoV-2, influenza A/B virus (IAV/IBV), and respiratory syncytial virus (RSV) are among the common viruses causing acute respiratory infections. Clinical diagnosis to differentiate these viruses is challenging due to similar clinical presentations; thus, laboratory-based real-time RT PCR is the…

2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation

Jeffrey K. F. Lai; I-Ching Sam; Pauline Verlhac et al.

Viruses, Vol. 9 No. 7 · 2017 · English · DOAJ Scopus

Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo. In this study, we report that EV-A71 triggers autolysosome formation during infection in human rhabdomyosarcoma (RD) cells to facilitate…