13 hasil untuk "Jiann-Ruey Hong"

Infectious spleen and kidney necrosis virus induces the reactive oxidative species/Nrf2-mediated oxidative stress response for the regulation of mitochondrion-mediated Bax/Bak cell death signals in GF-1 cells

Pin-Han Chen; Tsai-Ching Hsueh; Jiann-Ruey Hong

Frontiers in Microbiology, Vol. 13 · 2022 · Inggris · DOAJ Scopus

Infectious spleen and kidney necrosis virus (ISKNV) infections can trigger host cell death and are correlated with viral replication; however, they have rarely been considered in terms of the host organelle involvement. In the present study, we demonstrated that ISKNV triggered an oxidative stress…

ISKNV Triggers AMPK/mTOR-Mediated Autophagy Signaling through Oxidative Stress, Inducing Antioxidant Enzyme Expression and Enhancing Viral Replication in GF-1 Cells

Tsai-Ching Hsueh; Pin-Han Chen; Jiann-Ruey Hong

Viruses, Vol. 16 No. 6 · 2024 · Inggris · DOAJ Scopus

Infectious spleen and kidney necrosis virus (ISKNV) infections can induce the process of host cellular autophagy but have rarely been identified within the molecular autophagy signaling pathway. In the present study, we demonstrated that ISKNV induces ROS-mediated oxidative stress signals for the…

RNA Viruses: ROS-Mediated Cell Death

Mohammad Latif Reshi; Yi-Che Su; Jiann-Ruey Hong

International Journal of Cell Biology, Vol. 2014 · 2014 · Inggris · DOAJ Scopus

Reactive oxygen species (ROS) are well known for being both beneficial and deleterious. The main thrust of this review is to investigate the role of ROS in ribonucleic acid (RNA) virus pathogenesis. Much evidences has accumulated over the past decade, suggesting that patients infected with RNA…

Identification of Aquatic Birnavirus VP3 Death Domain and Its Dynamic Interaction Profiles in Early and Middle Replication Stages in Fish Cells

Jiann-Ruey Hong; Jen-Leih Wu

Viral Genomes - Molecular Structure, Diversity, Gene Expression Mechanisms and Host-Virus… · 2012 · Inggris · IntechOpen

A Mitochondrion-Targeting Protein (B2) Primes ROS/Nrf2-Mediated Stress Signals, Triggering Apoptosis and Necroptosis in Lung Cancer

Hsuan-Wen Chiu; Shao-Wen Hung; Ching-Feng Chiu dkk.

Biomedicines, Vol. 11 No. 1 · 2023 · Inggris · DOAJ Scopus

The betanodavirus B2 protein targets mitochondria and triggers mitochondrion-mediated cell death signaling in lung cancer cells; however, its molecular mechanism remains unknown. In this study, we observed that B2 triggers hydrogen peroxide/Nrf2-involved stress signals in the dynamic regulation of…

Infectious Spleen and Kidney Necrosis Virus (ISKNV) Triggers Mitochondria-Mediated Dynamic Interaction Signals via an Imbalance of Bax/Bak over Bcl-2/Bcl-xL in Fish Cells

Pin-Han Chen; Tsai-Ching Hsueh; Jen-Leih Wu dkk.

Viruses, Vol. 14 No. 5 · 2022 · Inggris · DOAJ Scopus

The molecular pathogenesis of infectious spleen and kidney necrosis virus (ISKNV) infections is important but has rarely been studied in connection to host organelle behavior. In the present study, we demonstrated that ISKNV can induce host cell death via a pro-apoptotic Bcl-2 and anti-apoptotic…

Aquatic Birnavirus-Induced ER Stress-Mediated Death Signaling Contribute to Downregulation of Bcl-2 Family Proteins in Salmon Embryo Cells

Hui Ling Huang; Jen Leih Wu; Mark Hung Chih Chen dkk.

PLoS ONE, Vol. 6 No. 8 · 2011 · Inggris · PLOS Scopus

Aquatic birnavirus induces mitochondria-mediated cell death, but whether connects to endoplasmic reticulum (ER) stress is still unknown. In this present, we characterized that IPNV infection triggers ER stress-mediated cell death via PKR/eIF2α phosphorylation signaling for regulating the Bcl-2…

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Betanodavirus Induces Oxidative Stress-Mediated Cell Death That Prevented by Anti-Oxidants and Zfcatalase in Fish Cells

Chih-Wei Chang; Yu-Chin Su; Guor-Mour Her dkk.

PLoS ONE, Vol. 6 No. 10 · 2011 · Inggris · PLOS Scopus

The role of oxidative stress in the pathogenesis of RNA nervous necrosis virus infection is still unknown. Red-spotted grouper nervous necrosis virus (RGNNV) induced free radical species (ROS) production at 12–24 h post-infection (pi; early replication stage) in fish GF-1 cells, and then at middle…

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The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish

Jo-Chi Hung; Jen-Leih Wu; Huei-Ching Li dkk.

Cells, Vol. 10 No. 11 · 2021 · Inggris · DOAJ Scopus

Studies have shown that the BH3-only domain Bad regulates brain development via the control of programmed cell death (PCD), but very few studies have addressed its effect on the molecular signaling of brain development in the system. In this work, we examined the novel role of zebrafish Bad in…

Stage-Specific Expression of TNFα Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells

Wei-Lun Wang; Jiann-Ruey Hong; Gen-Hwa Lin dkk.

PLoS ONE, Vol. 6 No. 2 · 2011 · Inggris · PLOS Scopus

Infectious pancreatic necrosis virus (IPNV) can induce Bad-mediated apoptosis followed by secondary necrosis in fish cells, but it is not known how these two types of cell death are regulated by IPNV. We found that IPNV infection can regulate Bad/Bid-mediated apoptotic and Rip1/ROS-mediated…

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