17 hasil untuk "Kotaro YAMADA"
Menampilkan 1–17 · 0,72 detik · RSS
-
Artikel Jurnal
Drone scheduling for parcel delivery with an access grade to stops on a fixed truck route
In this paper, we consider a parcel delivery scheduling problem of minimizing the total duration for a truck-drone distribution system to serve a given set of customers. The single carrier truck plays the role of a mobile depot of multiple identical drones, and the drones with unit capacity perform…
-
Artikel Jurnal
Proposal of data mining process for tool catalog data introducing machine learning
We attempt to construct a novel technology development utilizing big data such as Deep Learning in the manufacturing industry. Especially, we look at the data mining method and the tool catalog as a useful big data base which is updated by tool makers because it is easy for CAD/CAM engineers and…
-
Artikel Jurnal
Liver Hydrolysate Assists in the Recovery From Physical Fatigue in a Mouse Model
It is reported that liver hydrolysate (LH) enhances liver function. However, the effects of LH on physical fatigue are unknown. The aim of this study was to investigate the effect of LH on alterations in locomotor activity and energy metabolism such as 5′-AMP-activated protein kinase (AMPK)…
-
Artikel Jurnal
Analysis of drilling conditions by a catalog mining method based on Fuzzy c-means algorithm
To support the engineer in the selection of drills and their machining parameters, we propose a novel catalog mining system based on data mining techniques applied on drill catalogs by using twice the Fuzzy c-means method along with the Maximum Information Coefficient (MIC). We first perform the…
-
Artikel Jurnal
Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia
We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from…
-
Artikel Jurnal
Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice
Liver hydrolysate (LH) is used as a pharmaceutical agent in Japan, to enhance liver function. However, the effects of LH on sickness behavior are unknown. This study investigated the effect of LH on sickness behaviors, such as concanavalin A (ConA)-induced reduction of locomotor activity. ConA…
-
Artikel Jurnal
Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice
We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia…
-
Artikel Jurnal
Dacomitinib as a retreatment for advanced non‐small cell lung cancer patient with an uncommon EGFR mutation
Abstract In non‐small cell lung cancer (NSCLC), uncommon epidermal growth factor receptor (EGFR) mutations are mutations other than Ex19 deletion and Ex21 L858R, which are common mutations highly sensitive to EGFR‐tyrosine kinase inhibitors. Afatinib, a second‐generation EGFR‐tyrosine kinase…
-
Artikel Jurnal
Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
Recently, we has reported that AMPK activator has antidepressant effect. Previous our study suggested that liver hydrolysate (LH) activated adenosine monophosphate-activated protein kinase (AMPK) in periphery. However, the effect of LH on depression is unclear. Therefore, we examines whether LH has…
-
Artikel Jurnal
Pretreatment clinical and hematological predictors of efficacy and immune-related adverse events in patients with advanced non-small cell lung cancer receiving first-line chemotherapy combined with immune checkpoint inhibitors
Abstract Background The combination of immune checkpoint inhibitors (ICI) and platinum-based chemotherapy has rapidly become the standard first-line treatment for advanced or metastatic non-small cell lung cancer (NSCLC). However, identifying reliable predictive factors of treatment response…
-
Artikel Jurnal
Immunological effects of amivantamab in EGFR or MET-expressing non-small cell lung cancer
Abstract Background Epidermal growth factor receptor (EGFR) mutations represent one of the most frequent oncogenic driver in non-small cell lung cancer (NSCLC). Amivantamab, a bispecific antibody targeting EGFR and MET proto-oncogene, receptor tyrosine kinase (MET), has demonstrated clinical…
-
Artikel Jurnal
Dynamic Chest Radiography Visualizes Characteristic Respiratory Motion Impairment in Idiopathic Pleuroparenchymal Fibroelastosis: A Case Report
ABSTRACT Idiopathic pleuroparenchymal fibroelastosis (iPPFE) is a rare interstitial lung disease characterized by upper lobe‐predominant pleural fibrosis and restrictive ventilatory impairment. However, methods for functional assessment of respiratory motion remain limited. We reported a…
-
Artikel Jurnal
Diagnostic Challenge and Treatment Delay in Drowning-Associated Pneumonia: A Case of Combined Aeromonas, Legionella, and Aspergillus Infection
Drowning-associated pneumonia often involves multiple types of pathogens, including Aeromonas hydrophila, Legionella spp., and fungi. We report the case of an 82-year-old man who developed a rare combined infection with these three organisms after freshwater drowning. Initial therapy for typical…
-
Artikel Jurnal
Dual-positive anti-aminoacyl-tRNA synthetase and anti-melanoma differentiation-associated gene 5 antibody-related rapidly progressive interstitial lung disease in a patient with severe coronavirus disease 2019 complicated by probable pulmonary aspergillosis and pneumothorax: a case report
Abstract Background Occasionally, severe coronavirus disease 2019 (COVID-19) can lead to rapidly progressive interstitial lung disease (RP-ILD) by triggering or unmasking various myositis-specific autoantibodies (MSAs). Although dual positivity for anti-aminoacyl-tRNA synthetase (ARS) and…
-
Artikel Jurnal
MET Exon 14 Skipping Mutation‐Positive Lung Cancer With Multiple Cystic Airspaces: A Case Report
ABSTRACT Lung cancer with cystic airspaces (LCCA) is an uncommon radiological presentation that is frequently underrecognised and may be mistaken for benign or infectious pulmonary conditions. We report a case of lung adenocarcinoma presenting with multiple thin‐walled cystic lesions harbouring a…
-
Artikel Jurnal
Immune checkpoint inhibitor‐induced autoimmune limbic encephalitis with positivity for anti‐Hu antibodies in a patient with small‐cell lung cancer: A case report and literature review
Abstract In recent years, there has been an increasing number of studies on neurological symptoms induced as paraneoplastic neurological syndrome (PNS) or neurological immune‐related adverse events (irAEs) in patients treated with immune checkpoint inhibitors (ICIs). Herein, we report a 68‐year‐old…
-
Artikel Jurnal
Low-molecular-weight chondroitin sulfate attenuates hyperalgesia via immunomodulation of macrophage polarization
Osteoarthritis is the most common form of arthritis, for which effective and safer treatments are needed. While chondroitin sulfate (CS) has been reported to exert analgesic effects, its cellular targets and immunomodulatory mechanisms remain unclear. This study aimed to clarify the effects of…