15 results for "Li-Chen Chang"
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Journal Article
COVID-19 and long-term risk of incident laboratory-defined micronutrient deficiency in patients with type 2 diabetes: a multicenter propensity score–matched cohort study
BackgroundCOVID-19 has been linked to broad post-acute sequelae, but delayed micronutrient deficiency remains insufficiently characterized. Whether COVID-19 increases long-term risks of laboratory-defined vitamin D, magnesium, and vitamin B12 deficiencies among patients with type 2 diabetes…
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Journal Article
Association of low vitamin B12 status with incident dementia and stroke: an EHR database study
BackgroundEpidemiological evidence linking low vitamin B12 status to dementia risk remains inconsistent, partly reflecting differences in exposure definitions, study designs, and analytical approaches. This study evaluated the association between low vitamin B12 status and long-term risks of…
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Journal Article
Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study
BackgroundZinc deficiency is prevalent among older adults and individuals with dementia; however, its prognostic significance in this population remains unclear. We investigated the association between zinc deficiency and clinical outcomes in patients with dementia.MethodsThis retrospective matched…
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Journal Article
Association between preoperative anemia and revision risk after total shoulder arthroplasty: a multi-institutional cohort study
Abstract This retrospective cohort study explored the association between preoperative anemia and the risk of revision surgery following total shoulder arthroplasty (TSA). Using the TriNetX database, we analyzed patients aged ≥ 50 years who underwent primary TSA between 2010 and 2024. Patients were…
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Journal Article
Low serum zinc levels and risk of incident atrial fibrillation/flutter: a multi-institutional study
BackgroundAtrial fibrillation/flutter (AF) is increasingly prevalent, and identification of modifiable risk factors is a priority. Zinc deficiency (ZD) has been implicated in cardiovascular disease, but large-scale evidence linking ZD to incident AF remains limited.MethodsWe conducted a…
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Journal Article
Low vitamin D status and long-term risk of incident fibromyalgia: a propensity score–matched cohort study
BackgroundCross-sectional studies have reported lower serum vitamin D concentrations in patients with fibromyalgia, but whether vitamin D deficiency (VDD) precedes fibromyalgia onset remains uncertain. We conducted a large retrospective cohort study to evaluate the association between VDD and the…
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Journal Article
Association between iron deficiency anemia and the risk of new-onset tuberculosis infection: a matched cohort analysis
BackgroundTuberculosis remains a major global health challenge, with emerging evidence suggesting that micronutrient deficiencies may contribute to susceptibility to infection through impaired immune function. Iron deficiency anemia (IDA) is the most common nutritional deficiency worldwide…
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Journal Article
Long-term risk of incident dementia following documented COVID-19 among older adults with type 2 diabetes: a propensity score-matched cohort study
BackgroundType 2 diabetes mellitus (T2DM) is a well-established risk factor for dementia, and COVID-19 has been associated with persistent neurological and cognitive sequelae. However, whether this association extends beyond the early post-infection period among older adults with T2DM—a population…
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Journal Article
Comparison of the effects of dexmedetomidine and lidocaine on postoperative analgesia and recovery characteristics: a meta-analysis of randomized controlled trials
Abstract Background Dexmedetomidine and lidocaine are commonly used adjuvants in postoperative pain management; however, their comparative efficacy is unclear. This meta-analysis compared the effects of intravenous dexmedetomidine and lidocaine on postoperative analgesia and recovery. Methods…
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Journal Article
Elevated baseline vitamin B12 level and all-cause mortality risk in patients with sepsis: a cohort analysis
BackgroundElevated serum vitamin B12 levels have been associated with adverse outcomes in various clinical settings; however, the prognostic significance of pre-existing vitamin B12 elevation measured before sepsis onset remains unclear. This study examined the association between pre-sepsis…
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Journal Article
Association between COVID-19 and the development of chronic kidney disease in patients without initial acute kidney injury
Abstract While the association between COVID-19 and acute kidney injury (AKI) is well documented, the impact of COVID-19 on the development of advanced chronic kidney disease (CKD) remains unclear, particularly in patients without initial AKI. Using the TriNetX healthcare database, we conducted a…
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Journal Article Full text
Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer
In advanced prostate cancer, CREB (cAMP-responsive element-binding protein) binding protein (CBP) and its homolog EP300 are highly expressed; targeting the bromodomain of CBP is a new strategy for the treatment of prostate cancer. In the current study we identified Y08197, a novel…
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Journal Article
Vitamin D deficiency and risk of acute kidney injury after ischemic stroke: a propensity-matched cohort study
BackgroundVitamin D deficiency (VDD) has been linked to adverse outcomes in various clinical settings, but its relationship with post-stroke acute kidney injury (AKI) remains unexplored.MethodsThis retrospective cohort study utilized the TriNetX research network database to identify adult patients…
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Journal Article
Association between vitamin D deficiency and risk of venous thromboembolism: a matched cohort study of 139,690 patients
BackgroundVitamin D deficiency (VDD) may contribute to venous thromboembolism (VTE) through effects on coagulation and endothelial function, but existing studies show inconsistent results. We investigated the association between VDD and VTE risk using a large matched cohort design.MethodsWe…
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Journal Article
Vitamin D deficiency and diabetic retinopathy risk in patients with newly diagnosed type 2 diabetes mellitus: a retrospective analysis
BackgroundVitamin D deficiency (VDD) has emerged as a potential contributor to diabetic complications. This study aimed to investigate the association between VDD at the time of type 2 diabetes mellitus (T2DM) diagnosis and subsequent risk of developing diabetic retinopathy (DR).MethodsThis…