13 results for "Li-Xia Peng"

Epstein-Barr Virus_Encoded LMP1 Upregulates MicroRNA-21 to Promote the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin-Induced Apoptosis by Suppressing PDCD4 and Fas-L

Guang-Da Yang; Tie-Jun Huang; Li-Xia Peng et al.

PLoS ONE, Vol. 8 No. 10 · 2013 · English · PLOS Scopus

Approximately 30% of patients with Epstein-Barr virus (EBV)-positive advanced nasopharyngeal carcinoma (NPC) display chemoresistance to cisplatin-based regimens, but the underlying mechanisms are unclear. The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1), a functional homologue…

Also available at: DOAJ

Downregulation of Ras Association Domain Family Member 6 (RASSF6) Underlies the Treatment Resistance of Highly Metastatic Nasopharyngeal Carcinoma Cells

Ying-Ying Liang; Ming-Yuan Chen; Yi-Jun Hua et al.

PLoS ONE, Vol. 9 No. 7 · 2014 · English · PLOS Scopus

Radiation and cisplatin-based chemotherapy are major treatments for nasopharyngeal carcinoma (NPC). However, a major impediment for further improving the cure rate is the development of treatment resistance with an undetermined molecular mechanism in metastatic NPC cells. Our established, highly…

Also available at: DOAJ

The autoregulatory serglycin/CD44 axis drives stemness‐like phenotypes in TNBC in a β‐catenin‐dependent manner

Li Cao; Fei‐Fei Luo; Hong‐Bin Huang et al.

Clinical and Translational Medicine, Vol. 11 No. 2 · 2021 · English · DOAJ Scopus

SPI1-Mediated Upregulation of the CST1 Gene as an Independent Poor Prognostic Factor Accelerates Metastasis in Esophageal Squamous Cell Carcinoma (ESCC) by Interacting with MMP2

Fei-Fei Luo; Jing Wang; Zhan-Fei Zhang et al.

Frontiers in Bioscience-Landmark, Vol. 28 No. 9 · 2023 · English · DOAJ Scopus

Background: Esophageal squamous cell carcinoma (ESCC) is a highly lethal tumor type, but studies on the ESCC tumor microenvironment are limited. We found that cystatin SN (CST1) plays an important role in the ESCC tumor microenvironment. CST1 has been reported to act as an oncogene in multiple…

Next-generation sequencing-based population genetics unravels the evolutionary history of Rhodomyrtus tomentosa in China

Xing-ming Xu; Bo-yong Liao; Su-jiao Liao et al.

BMC Plant Biology, Vol. 25 No. 1 · 2025 · English · DOAJ Scopus

Abstract Background Rhodomyrtus tomentosa (Ait.) Hassk. is useful for its ornamental, medicinal, and ecological characteristics, and is considered a “Neglected and Underutilized Crop Species”. However, our understanding of the geographic structure and evolutionary history of its wild populations is…

GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner

Fen Lin; Yu-Jie Xie; Xin-Ke Zhang et al.

Journal of Experimental & Clinical Cancer Research, Vol. 38 No. 1 · 2019 · English · DOAJ Scopus

Abstract Background With the rapid development of the high throughput detection techniques, tumor-related Omics data has become an important source for studying the mechanism of tumor progression including breast cancer, one of the major malignancies worldwide. A previous study has shown that the…

Association of Socioeconomic Disparities With Nasopharyngeal Carcinoma Survival in an Endemic Area, China

Dong-Fang Meng MD, PhD; Hai-Bo Zhang MD, PhD; Guo-Ying Liu MD, PhD et al.

Cancer Control, Vol. 30 · 2023 · English · DOAJ Scopus

Objectives This retrospective cohort study investigated the association of socioeconomic status with survival outcomes among patients with nasopharyngeal carcinoma in an endemic area of China. Methods The primary endpoint was overall survival. Survival outcomes were estimated by the Kaplan-Meier…

Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma

Meng-Jie Yang; Jie Guo; Yan-Fang Ye et al.

Cancer Communications, Vol. 38 No. 1 · 2018 · English · DOAJ Scopus

Abstract Background The association of circulating inflammation markers with nasopharyngeal carcinoma (NPC) is still largely unclear. This study aimed to comprehensively explore the relationship between circulating cytokine levels and the subsequent risk of NPC with a two-stage epidemiologic study…

Geographical disparities in the prognosis of patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a large institution-based cohort study from an endemic area

Rui Sun; Hao Hu; Qi Yang et al.

BMJ Open, Vol. 10 No. 11 · 2020 · English · DOAJ Scopus

Objectives Geographical disparities have been identified as a specific barrier to cancer screening and a cause of worse outcomes for patients with cancer. In the present study, our aim was to assess the influence of geographical disparities on the survival outcomes of patients with nasopharyngeal…

Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling

Yuan-Yuan Qiang; Chang-Zhi Li; Rui Sun et al.

Journal of Experimental & Clinical Cancer Research, Vol. 37 No. 1 · 2018 · English · DOAJ Scopus

Abstract Background CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional and molecular mechanisms by which CLCA2 influences NPC. Methods CLCA2…

Erratum to: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling

Dong-Fang Meng; Ping Xie; Li-Xia Peng et al.

Journal of Experimental & Clinical Cancer Research, Vol. 36 No. 1 · 2017 · English · DOAJ Scopus