8 hasil untuk "Li-Yen Shiu"

Transplantation of 3D adipose-derived stem cell/hepatocyte spheroids alleviates chronic hepatic damage in a rat model of thioacetamide-induced liver cirrhosis

Yu Chiuan Wu; Guan Xuan Wu; Kuan Wei Chen dkk.

Scientific Reports, Vol. 12 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Cirrhosis refers to irreversible liver damage where healthy tissue is replaced by scar tissue, resulting in impaired liver function. There is no cure and current treatments only prevent further liver damage; thus, novel therapeutic options are urgently needed. Here, we report a new…

Combinatory effects of current regimens and Guizhi Fuling Wan on the development of endometriosis

Chih-Chen Chen; Chun-Yen Huang; Li-Yen Shiu dkk.

Taiwanese Journal of Obstetrics & Gynecology, Vol. 61 No. 1 · 2022 · Inggris · DOAJ Scopus

Objective: Endometriosis, defined as the growth of endometrial glands and stromal cells in a heterotopic location under the cyclic influence of ovarian hormones, is a common gynecological disorder manifested by chronic pelvic pain and infertility. In traditional Chinese medicine, endometriosis is…

Adipose-Derived Mesenchymal Stem Cells-Conditioned Medium Modulates the Expression of Inflammation Induced Bone Morphogenetic Protein-2, -5 and -6 as Well as Compared with Shockwave Therapy on Rat Knee Osteoarthritis

Jai-Hong Cheng; Chieh-Cheng Hsu; Shan-Ling Hsu dkk.

Biomedicines, Vol. 9 No. 10 · 2021 · Inggris · DOAJ Scopus

The dose-dependent effects of adipose-derived mesenchymal stem cell-conditioned medium (ADSC-CM) were compared with those of shockwave (SW) therapy in the treatment of early osteoarthritis (OA). Anterior cruciate ligament transaction (ACLT) with medial meniscectomy (MMx) was performed in rats…

Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A

Chang-Han Chen; Hsin-Ting Tsai; Hui-Ching Chuang dkk.

Scientific Reports, Vol. 7 No. 1 · 2017 · Inggris · DOAJ Scopus

Abstract Conventional therapeutic processes in patient with OSCC are associated with several unfavorable effects leading to patients with poor survival rate. Metformin has been shown to protect against a variety of specific diseases, including cancer. However, the precise roles and mechanisms…

Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis

Chung-Feng Hwang; Li-Yen Shiu; Li-Jen Su dkk.

PLoS ONE, Vol. 8 No. 12 · 2013 · Inggris · PLOS Scopus

Background: Nasopharyngeal carcinoma (NPC) is known for its high metastatic potential and locoregional recurrence, although the molecular alterations that are driving NPC metastasis remain unclear at this time. This study aimed to examine the expression of fibulin-5 in NPC, correlate the results…

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A novel therapeutic approach for endometriosis using adipose-derived stem cell-derived conditioned medium- A new hope for endometriotic patients in improving fertility

S. Joseph Huang; Chun-Yen Huang; Yu-Hao Huang dkk.

Frontiers in Endocrinology, Vol. 14 · 2023 · Inggris · DOAJ Scopus

IntroductionEndometriosis is defined as the growth of endometrial glands and stromal cells in a heterotopic location with immune dysregulation. It usually leads to chronic pelvic pain and subfertility. Although various treatments are available, the recurrence rate remains high. Adipose tissue is an…

An integrated analysis of dysregulated SCD1 in human cancers and functional verification of miR-181a-5p/SCD1 axis in esophageal squamous cell carcinoma

Bing-Yen Wang; Yuan-Yen Chang; Li-Yen Shiu dkk.

Computational and Structural Biotechnology Journal, Vol. 21 · 2023 · Inggris · DOAJ Scopus

Esophageal squamous cell carcinoma (ESCC), one of the most lethal cancers, has become a global health issue. Stearoyl-coA desaturase 1 (SCD1) has been demonstrated to play a crucial role in human cancers. However, pan-cancer analysis has revealed little evidence to date. In the current study, we…