13 results for "Lingjun Cui"

Metabolomics and network pharmacology-based identification of phenolic acids in Polygonatum kingianum var. grandifolium rhizomes as anti-cancer/Tumor active ingredients

Xiaolin Wan; Lingjun Cui; Qiang Xiao

PLOS ONE, Vol. 19 No. 12 · 2024 · English · PLOS Scopus

Broadly targeted metabolomics techniques were used to identify phenolic acid compounds in Polygonatum kingianum var. grandifolium (PKVG) rhizomes and retrieve anti-cancer/tumor active substance bases from them. We identified potential drug targets by constructing Venn diagrams of compound and…

Also available at: DOAJ

Integrative analysis of the metabolome and transcriptome provides insights into the mechanisms of amino acids and their derivatives biosynthesis in Polygonatum

Xiuzhi Wang; Lingjun Cui; Qiang Xiao

PLOS One, Vol. 20 No. 6 · 2025 · English · PLOS Scopus

The composition and concentration of amino acids and their derivatives in Polygonatum are crucial factors that indicate its nutritional value and have a substantial impact on its potential for market development as a medicinal and edible plant. This study utilized comprehensive targeted…

Also available at: DOAJ

Response mechanism of major secondary metabolites of Polygonatum kingianum to selenium nanoparticles

Xiaolin Wan; Jiehua Wang; Jiaxin Zhang et al.

Frontiers in Plant Science, Vol. 15 · 2024 · English · DOAJ Scopus

Selenium nanoparticles (SeNPs) can be absorbed by plants, thereby affecting plant physiological activity, regulating gene expression, and altering metabolite content. However, the molecular mechanisms by which exogenous selenium affects Polygonatum kingianum coll.et Hemsl plant secondary…

Exploring the metabolic characteristics of fresh-cut sweet potatoes at different storage times based on untargeted metabolomics

Xiaolin Wan; Xiuzhi Wang; Moxian Chen et al.

Food Chemistry: X, Vol. 37 · 2026 · English · DOAJ Scopus

Sweet potato (Ipomoea batatas (L.) Lam.) is an important tuber crop. This study employed LC-MS/MS to investigate metabolic responses in fresh-cut purple sweet potatoes during short-term storage (0–5 d). Fresh cutting and storage jointly reprogrammed metabolic networks, with both basal metabolite…

Metabolomics combined with network pharmacology reveals the anti-hepatoma effects of terpenoids from Polygonatum kingianum var. grandifolium and Polygonatum sibiricum Redouté as well as differences in their terpenoid metabolites

Xiuzhi Wang; Xiaolin Wan; Tianrun Zhu et al.

BMC Plant Biology, Vol. 25 No. 1 · 2025 · English · DOAJ Scopus

Abstract Liver cancer remains a smajor cause of mortality worldwide, underscoring the urgent need for novel natural therapeutics. Polygonatum kingianum var. grandifolium (PK) and Polygonatum sibiricum Redouté (PS) are rice in terpenoids, yet their anti-liver cancer mechanisms remain poorly…

Comparative study of polysaccharide metabolites in purple, orange, and white Ipomoea batatas tubers

Xiuzhi Wang; Xiaolin Wan; Jiaqi Wu et al.

Food Chemistry: X, Vol. 24 · 2024 · English · DOAJ Scopus

We employed LC-MS/MS to investigate the metabolic profiles of polysaccharide compounds in white, orange, and purple sweet potato flesh. Comparisons between Orange vs White, Purple vs Orange, and Purple vs White identified 69 polysaccharide metabolites, including 23, 36, and 44 differential…

Accumulation patterns of flavonoids and phenolic acids in different colored sweet potato flesh revealed based on untargeted metabolomics

Xiaolin Wan; Jiaqi Wu; Xiuzhi Wang et al.

Food Chemistry: X, Vol. 23 · 2024 · English · DOAJ Scopus

Sweet potatoes are rich in flavonoids and phenolic acids, showing incomparable nutritional and health value. In this investigation, we comprehensively analyzed the secondary metabolite profiles in the flesh of different-colored sweet potato flesh. We determined the metabolomic profiles of white…

Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm

Lingjun CUI; Chao TIAN; Zixuan CHENG et al.

Zhongguo aizheng zazhi, Vol. 32 · 2022 · Chinese · DOAJ Scopus

Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare, heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exploration of its pathogenesis and treatment…

Projecting the future redistribution of Pinus koraiensis (Pinaceae: Pinoideae: Pinus) in China using machine learning

Xin Chen; Kaitong Xiao; Ruixiong Deng et al.

Frontiers in Forests and Global Change, Vol. 7 · 2024 · English · DOAJ Scopus

IntroductionAs an important coniferous tree in northeast China, Pinus koraiensis not only maintains the stability of the forest ecosystem at high latitudes but also plays a crucial role in regional socioeconomic development. With the intensification of climate change in recent years, the stability…

Management Methods and Duration Induces Changes in Soil Microbial Communities of Carya cathayensis var. dabeishansis Forests

Cheng Huang; Hua Liu; Shu‐Yi‐Dan Zhou et al.

Ecology and Evolution, Vol. 15 No. 9 · 2025 · English · DOAJ Scopus

ABSTRACT Soil microbial communities are involved in and contribute to several processes in soil ecosystems. Nonetheless, how various forest management approaches and their timeframes influence soil microbial community composition and network complexity is poorly understood. Hence, in this study, a…

Real-world evidence for Qizhen Yiliu formula in nonfunctional pancreatic neuroendocrine tumors after radical resection: a multicenter, retrospective study with propensity score matching

Fuhuan Yu; Zixuan Cheng; Lingjun Cui et al.

Journal of Pancreatology, Vol. 9 No. 2 · 2026 · English · DOAJ Scopus

Objective:. Despite radical resection, postoperative recurrence of nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) remains common, particularly among high-risk patients. This study evaluates the adjuvant therapeutic potential of Qizhen Yiliu Formula (QZYL) in a multicenter real-world…