10 results for "Mahboube Rahmati Kukandeh"
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Investigatig of the Effects of N-Acetylcysteine on Cyclophosphamide-Induced Oxidative Stress in HeLa Cells
Background and purpose: Cyclophosphamide (CP) is an alkylating agent widely used in the treatment of hematological malignancies, various epithelial tumors, and certain non-malignant diseases. N-Acetylcysteine (NAC) is an antioxidant with free radical scavenging activity that helps restore…
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Determining the Protective Effect of L-Arginine Against Amikacin-Induced Nephrotoxicity in Normal African Green Monkey Kidney Epithelial Cells by Evaluating Oxidative Stress Parameters
Background and Objective: Due to high metabolic activity and rich blood supply, the kidneys are exposed to high levels of reactive oxygen species (ROS) under pathological conditions, making them highly vulnerable to oxidative stress. Nephrotoxic agents, such as cisplatin, aminoglycosides, and…
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Effect of Curcumin on Docetaxel-Induced Apoptosis in the DU145 (Prostate) Cell Line Using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide Assay
Background and Objective: Prostate cancer is one of the most common malignancies worldwide. Docetaxel (DTX) is proposed as a well-known compound for prostate tumor chemotherapy, and its function is based on inhibiting microtubule depolymerization, disrupting microtubule balance, and consequently…
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Synergistic Effects of Carvacrol and Thymol on Docetaxel-Induced Cytotoxicity in the A549 Cell Line by Evaluating Cell Viability and Oxidative Stress
Background and Objective: Docetaxel is an effective chemotherapy drug for treating lung cancer, but its side effects and cytotoxicity limit its use. Natural compounds like carvacrol and thymol, known for their anti-cancer and anti-inflammatory properties, have gained attention as adjunct agents to…
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Protective Effects of Lycopene and Coenzyme Q10 Against 5-Fluorouracil-Induced Genotoxicity in SW480 (Colorectal Cancer) and Bone Marrow Mesenchymal Stem Cells Cell Lines: A Comet Assay Study
Background and Objective: 5-fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer treatment; however, its genotoxicity can lead to deoxyribonucleic acid (DNA) damage in healthy cells. Lycopene and Coenzyme Q10 are natural antioxidants capable of exerting protective…
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Investigating the Synergistic Effects of Aspartic Acid and Tocopherol on Cytotoxicity and Oxidative Stress Caused by Etoposide on Hepg2 Cell Line by MTT and ROS Methods
Introduction: Liver cancer ranks among the deadliest cancers globally. Etoposide, a chemotherapeutic agent frequently utilized in treatment, inhibits topoisomerase II, leading to cell cycle arrest and apoptosis induction. Nonetheless, etoposide generates reactive oxygen species (ROS), resulting in…
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IGFBP-3 enhances irinotecan efficacy in colorectal cancer via ROS-mediated apoptosis and β-catenin suppression
Background and purpose: Colorectal cancer, a leading cause of mortality, is treated with surgery early and irinotecan (IRI) chemotherapy in advanced stages. Insulin-like growth factor-binding protein 3 (IGFBP-3), regulated by p53, mediates tumor suppression and apoptosis. This study evaluates the…
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Protective Effects of Vitamin E and Aqueous Extract of Thymus vulgaris Leaves Against Amiodarone-Induced Cytotoxicity in Non-Cancerous Human Lung Fibroblast (HLF) and Human Lung Cancer (A549) Cell Lines
Background and Objective: Amiodarone is an effective antiarrhythmic drug used for cardiac arrhythmias. Due to the presence of iodine in its structure, it tends to accumulate in lipophilic tissues, including the lungs, leading to lung injury and other major adverse effects. The present study aimed…
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Cellular Effects of Naringin in Prevention of Genotoxicity Caused by Mifepristone on Human Blood Lymphocytes
Background and purpose: Mifepristone is an oral synthetic steroid with antiglucocorticoid and antiprogesterone activities. Therefore, it could be dangerous during pregnancy since it causes cytogenetic damage and, consequently, abortion. Flavonoid compounds such as naringin have antioxidant…
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Protective effects of hydroalcoholic extract of ginger on DNA damage and viability of PC12 cells exposed to sodium dithionite
Background and purpose: This study focused on sodium dithionite, a chemical widely used in various industries, which causes oxidative damage to cells and DNA. Considering the well-known antioxidant properties of ginger, the research investigated the effects of hydroalcoholic ginger extract on…