34 results for "Manish Modi"
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Journal Article
Successful use of valproate in Kleine-Levin syndrome: A case report and review of cases reported from India
Kleine-Levin syndrome (KLS) is characterized by recurrent episodes of hypersomnia and other symptoms and it is a really challenging for the physician, since its causes are not yet clear, and available treatment options are not having adequate support. Here, we are reporting a case with successful…
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Journal Article
Oculogyric crisis with clozapine: A case report and review of similar case reports in the literature
Oculogyric crisis (OGC) is a dystonic reaction and commonly caused by typical antipsychotics and rarely occurs with clozapine. Here, we are presenting a case of OGC with clozapine therapy and reviewing the similar cases reported in the literature.
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Psychiatric morbidity in patients with idiopathic Parkinson's disease: A cross-sectional study
Objective: To evaluate the prevalence of psychiatric comorbidities in patients with idiopathic Parkinson's disease (IPD). Methodology: Two hundred and thirty-nine patients with IPD were evaluated on Mini-International Neuropsychiatric Interview PLUS (MINI-PLUS). In addition, patients found to have…
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Journal Article
Chronic meningitis in systemic lupus erythematosus: An unusual etiology
Chronic aseptic meningitis is a rare manifestation of systemic lupus erythematosus (SLE). Apart from immunological causes and drugs, the aseptic meningitis group can include some unidentified viral infections that cannot be detected by routine microbiological testing. It is imperative to do…
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Journal Article
Reversible dementia as a presenting manifestation of racemose neurocysticercosis
Racemose cysticercosis is a less frequent presentation of neurocysticercosis (NCC). It′s presentation and management is quite different from cerebral parenchymal NCC. Diagnosis of racemose cysticercosis is based on the combination of clinical, epidemiologic, radiographic, and immunologic…
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Journal Article
Vitamin D status and risk of ischemic stroke in North Indian patients
Context: Accumulating evidence suggests that vitamin D deficiency is associated with increased risk of stroke. Contributing mechanisms have been linked to the association of vitamin D deficiency with the presence of hypertension, diabetes mellitus, and atherosclerosis, however, the evidence is…
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Role of multiplex polymerase chain reaction using IS6110 and Protein b for the diagnosis of extra-pulmonary tuberculosis: North India
Background: Prompt and accurate diagnosis of extra-pulmonary tuberculosis (TB) is highly challenging. Current conventional techniques lack sensitivity and are time-consuming. Here, we report our experience with multiplex polymerase chain reaction (MPCR) using two targets namely IS6110 and protein…
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Journal Article Full text
Rapidly progressive dementia: An eight year (2008–2016) retrospective study
BACKGROUND AND PURPOSE: Rapidly progressive dementia (RPD) is an emergency in cognitive neurology, defined as cognitive impairment affecting the daily living activities developed over less than 1 year. This study investigated the profile of patients with rapidly progressive dementia at first…
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Journal Article
Assessment of Blood–Brain Barrier Integrity in Tuberculous Meningitis Using Dynamic Contrast-Enhanced MR Perfusion
Objective Tuberculous meningitis (TBM) is the most common form of central nervous system tuberculosis. The aim of the study was to quantitatively evaluate blood–brain barrier (BBB) perfusion changes in TBM patients using dynamic contrast-enhanced (DCE) MR perfusion. Methods and Material Thirty…
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Journal Article
Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
Objectives: Subacute sclerosing panencephalitis (SSPE) is rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection with measles virus. No cure for SSPE exists, but the condition can be managed by medication if treatment is started at…
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Journal Article Full text
Effect of Mycobacterium tuberculosis Lineage, Drug Resistance and HIV Status on the Outcome of Patients with Tuberculous Meningitis
Introduction: Tuberculous Meningitis (TBM) is a devastating disease with high morbidity and mortality. Resistance to anti tubercular drugs, strain variation among M. tuberculosis and HIV status of the host are important factors governing the disease progression in pulmonary tuberculosis and data…
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Prospective Analysis of 55 Cases of Tuberculosis Meningitis (TBM) in North India
Introduction: To assess the clinical profile, laboratory and neuroimaging data of adult tuberculous meningitis (TBM) patients and to determine the predictors of mortality. Materials and Methods: A total of 55 TBM patients and 60 controls were enrolled in this prospective study. Detailed clinical…
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Role of Plasma Clusterin in Alzheimer’s Disease—A Pilot Study in a Tertiary Hospital in Northern India
Objective: To evaluate the role of plasma clusterin in Alzheimer’s disease (AD). Background: Plasma clusterin is a promising biomarker as various studies have shown it to be associated with AD. But other studies have shown that plasma clusterin levels were not related to Alzheimer’s disease or…
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Journal Article
Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population
Abstract Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-induced idiosyncratic adverse effects. Current…
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Journal Article
Epidemic of mucormycosis in COVID-19 pandemic: A position paper
During the second wave of COVID-19 pandemic, there is a sudden increase in number of cases mucormycosis infection in India. This communication by the Tropical Neurology subsection expert group of the Indian Academy of Neurology (IAN) describes the clinical and diagnostic features, treatment of the…