7 hasil untuk "Maxwell A. Ruby"

VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

Maxwell A. Ruby; Benjamin Goldenson; Gabriela Orasanu dkk.

Journal of Lipid Research, Vol. 51 No. 8 · 2010 · Inggris · DOAJ Scopus

Recent evidence suggests that lipoproteins serve as circulating reservoirs of peroxisomal proliferator activated receptor (PPAR) ligands that are accessible through lipolysis. The present study was conducted to determine the biochemical basis of PPAR-α activation by lipolysis products and their…

Acute Overactive Endocannabinoid Signaling Induces Glucose Intolerance, Hepatic Steatosis, and Novel Cannabinoid Receptor 1 Responsive Genes

Maxwell A. Ruby; Daniel K. Nomura; Carolyn S. S. Hudak dkk.

PLoS ONE, Vol. 6 No. 11 · 2011 · Inggris · PLOS Scopus

Endocannabinoids regulate energy balance and lipid metabolism by stimulating the cannabinoid receptor type 1 (CB1). Genetic deletion and pharmacological antagonism have shown that CB1 signaling is necessary for the development of obesity and related metabolic disturbances. However, the sufficiency…

Juga tersedia di: DOAJ

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients

Henriette Kirchner; Indranil Sinha; Hui Gao dkk.

Molecular Metabolism, Vol. 5 No. 3 · 2016 · Inggris · DOAJ Scopus

Objective: Epigenetic modifications contribute to the etiology of type 2 diabetes. Method: We performed genome-wide methylome and transcriptome analysis in liver from severely obese men with or without type 2 diabetes and non-obese men to discover aberrant pathways underlying the development of…

Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion

Iwona Szczerbinska; Annamaria Tessitore; Lena Kristina Hansson dkk.

Biomedicines, Vol. 10 No. 1 · 2022 · Inggris · DOAJ Scopus

Type 2 diabetes (T2D) is a chronic metabolic disorder affecting almost half a billion people worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an underlying factor in the pathophysiology of the disease. Understanding the cellular mechanisms regulating appropriate…

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Maxwell A. Ruby; Julie Massart; Devon M. Hunerdosse dkk.

Cell Reports, Vol. 18 No. 3 · 2017 · Inggris · DOAJ Scopus

Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to gain mechanistic insight into the…

Hepatocyte mARC1 promotes fatty liver disease

Lara C. Lewis; Lingyan Chen; L. Shahul Hameed dkk.

JHEP Reports, Vol. 5 No. 5 · 2023 · Inggris · DOAJ Scopus

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new therapeutics. Genetic variants in mitochondrial…