10 hasil untuk "Nicholas Stephanopoulos"
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Artikel Jurnal Teks lengkap
DNA Nanodevices as Mechanical Probes of Protein Structure and Function
DNA nanotechnology has reported a wide range of structurally tunable scaffolds with precise control over their size, shape and mechanical properties. One promising application of these nanodevices is as probes for protein function or determination of protein structure. In this perspective we cover…
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Artikel Jurnal
Construction of Reconfigurable and Polymorphic DNA Origami Assemblies with Coiled‐Coil Patches and Patterns
Abstract DNA origami nanodevices achieve programmable structure and tunable mechanical and dynamic properties by leveraging the sequence‐specific interactions of nucleic acids. Previous advances have also established DNA origami as a useful building block to make well‐defined micron‐scale…
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Artikel Jurnal
Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics
Methods to study conformational changes in biomolecules are limited in resolution and require labelling or other modifications of target analytes. Here the authors present a label-free, microwave microfluidic approach to detect conformational changes of DNA nanostructures based on ionic…
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Artikel Jurnal
The influence of Holliday junction sequence and dynamics on DNA crystal self-assembly
Engineered crystal architectures from DNA have become a foundational goal for nanotechnological precise arrangement. Here, the authors systematically investigate the structures of 36 immobile Holliday junction sequences and identify the features allowing the crystallisation of most of them, while 6…
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Artikel Jurnal
Instructing cells with programmable peptide DNA hybrids
The extracellular matrix can affect cell behaviour both physically and biochemically. Here, the authors developed a substrate that is based on peptides and nucleic acids hybrids that can dynamically present signals upon demand which regulate cell adhesion and migration, thereby controlling cell…
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Artikel Jurnal Teks lengkap
Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles
The use of human embryonic stem cells (hESCs) for regeneration of the spiral ganglion will require techniques for promoting otic neuronal progenitor (ONP) differentiation, anchoring of cells to anatomically appropriate and specific niches, and long-term cell survival after transplantation. In this…
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Artikel Jurnal Teks lengkap
The living interface between synthetic biology and biomaterial design
Recent far-reaching advances in synthetic biology have yielded exciting tools for the creation of new materials. Conversely, advances in the fundamental understanding of soft-condensed matter, polymers and biomaterials offer new avenues to extend the reach of synthetic biology. The broad and…
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Artikel Jurnal
Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer
Abstract The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional kinase inhibitors. The FAK scaffold function largely involves the interaction between FAK’s focal adhesion targeting (FAT) domain and paxillin…