9 hasil untuk "R. Graham Cooks"
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Artikel Jurnal
Inter-platform assessment of performance of high-throughput desorption electrospray ionization mass spectrometry
High throughput analysis is increasingly relevant in both industry and academia, with applications reaching from enzymology and drug discovery to organic reaction optimization and diagnostics. Currently, chromatography-free mass spectrometry (MS) techniques have acquired an important role in this…
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Artikel Jurnal
Complex mixture analysis by two-dimensional mass spectrometry using a miniature ion trap
Quadrupole ion trap mass spectrometers are robust instruments that can perform tandem mass spectrometry (MS/MS) while being operated under moderate vacuum conditions. These features make quadrupole ion traps an attractive option as miniature mass spectrometers, particularly because the sensitivity…
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Artikel Jurnal Teks lengkap
Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments
Various organic reactions, including important synthetic reactions involving C-C, C-N, and C-O bond formation as well as reactions of biomolecules, are accelerated when the reagents are present in sprayed or levitated microdroplets or in thin films. The reaction rates increase by orders of…
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Artikel Jurnal
Spontaneous Water Radical Cation Oxidation at Double Bonds in Microdroplets
Spontaneous oxidation of compounds containing diverse X=Y moieties (e.g., sulfonamides, ketones, esters, sulfones) occurs readily in organic-solvent microdroplets. This surprising phenomenon is proposed to be driven by the generation of an intermediate species [M+H2O]+·: a covalent adduct of water…
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Artikel Jurnal
Detection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry
Abstract Desorption electrospray ionization (DESI) tandem mass spectrometry (MS) is used to assess mutation status of isocitrate dehydrogenase (IDH) in human gliomas. Due to the diffuse nature of gliomas, total gross resection is not normally achieved during surgery, leading to tumor recurrence…
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Artikel Jurnal Teks lengkap
Differential Lipid Profiles of Normal Human Brain Matter and Gliomas by Positive and Negative Mode Desorption Electrospray Ionization – Mass Spectrometry Imaging
Desorption electrospray ionization—mass spectrometry (DESI-MS) imaging was used to analyze unmodified human brain tissue sections from 39 subjects sequentially in the positive and negative ionization modes. Acquisition of both MS polarities allowed more complete analysis of the human brain tumor…
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Artikel Jurnal
Fatty Acid Patterns Detected By Ambient Ionization Mass Spectrometry in Canine Invasive Urothelial Carcinoma From Dogs of Different Breeds
Background: In early work ambient ionization mass spectrometry (MS) revealed lipid patterns distinguishing muscle invasive bladder cancer (invasive urothelial carcinoma, InvUC) from normal urothelium. A new ambient ionization MS approach, touch spray MS (TS-MS) can rapidly generate mass spectra in…
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Artikel Jurnal
High-throughput analysis of tissue microarrays using automated desorption electrospray ionization mass spectrometry
Abstract Tissue microarrays (TMAs) are commonly used for the rapid analysis of large numbers of tissue samples, often in morphological assessments but increasingly in spectroscopic analysis, where specific molecular markers are targeted via immunostaining. Here we report the use of an automated…