6 results for "Rachel Cohn"

The heterogeneity of cellular senescence: insights at the single-cell level

Rachel Cohn; Nathan Gasek; George A. Kuchel et al.

Trends in Cell Biology · 2022 · English · OpenAlex Scopus

Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

Feria A. Ladha; Ketan Thakar; Anthony M. Pettinato et al.

Cell Reports, Vol. 36 No. 6 · 2021 · English · DOAJ Scopus

Summary: Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes. We identify 324 actinin proximity partners, including those…

A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations

Rachel Cohn; Ketan Thakar; Andre Lowe et al.

Stem Cell Reports, Vol. 12 No. 1 · 2019 · English · DOAJ Scopus

…contraction stress and candidate therapeutic target for HCM patients. : Cohn et al. show that thick-filament sarcomere mutations that cause hypertrophic cardiomyopathy result in hypercontractility in human cardiac microtissues engineered from isogenic iPSCs. These findings illustrate that…

Samaki Salama – Promoting healthy child growth and sustainable fisheries in coastal Kenya: A study protocol

Ivy Blackmore; Andrew Wamukota; Elizabeth Kamau-Mbuthia et al.

Frontiers in Public Health, Vol. 10 · 2022 · English · DOAJ Scopus

BackgroundOne in five young children globally suffer the consequences of stunted growth and development and millions experience deficiencies in zinc, iron, iodine, vitamins A and B12, nutrients found bioavailable in fish foods. Small-scale fisheries have the potential to generate income and augment…

Adult mouse fibroblasts retain organ-specific transcriptomic identity

Elvira Forte; Mirana Ramialison; Hieu T Nim et al.

eLife, Vol. 11 · 2022 · English · DOAJ

Organ fibroblasts are essential components of homeostatic and diseased tissues. They participate in sculpting the extracellular matrix, sensing the microenvironment, and communicating with other resident cells. Recent studies have revealed transcriptomic heterogeneity among fibroblasts within and…

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Anthony M. Pettinato; Dasom Yoo; Jennifer VanOudenhove et al.

Cell Reports, Vol. 35 No. 5 · 2021 · English · DOAJ Scopus

Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using fluorescently tagged cyclin B1 and cardiac…