11 hasil untuk "Sarah J. MacEachern"
Menampilkan 1–11 · 0,01 detik · RSS
-
Artikel Jurnal Teks lengkap
Machine learning for precision medicine
Precision medicine is an emerging approach to clinical research and patient care that focuses on understanding and treating disease by integrating multi-modal or multi-omics data from an individual to make patient-tailored decisions. With the large and complex datasets generated using precision…
-
Artikel Jurnal
Application of a localized morphometrics approach to imaging-derived brain phenotypes for genotype-phenotype associations in pediatric mental health and neurodevelopmental disorders
IntroductionQuantitative global or regional brain imaging measurements, known as imaging-specific or -derived phenotypes (IDPs), are commonly used in genotype-phenotype association studies to explore the genomic architecture of the brain and how it may be affected by neurological diseases (e.g…
-
Artikel Jurnal Teks lengkap
Mitochondrial Dysfunction in Autism and Attention-Deficit/Hyperactivity Disorder: Evidence from Genetic, Biochemical, and Neuroimaging Approaches
Mitochondrial dysfunction has been increasingly implicated in the pathobiology of neurodevelopmental conditions, particularly autism and attention-deficit/hyperactivity disorder (ADHD). Because the developing brain is critically dependent on sustained ATP production, impairments in oxidative…
-
Artikel Jurnal
Age-stratified multimodal MRI and machine learning to explore autism-related brain characteristics in youth
PurposeAutism is a common neurodevelopmental condition (NDC) that is characterized by restricted, repetitive behaviors and social communication differences that can impact the daily functioning of individuals. The clinical diagnosis of autism can be challenging, mainly due to its behavioral…
-
Artikel Jurnal
Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs
Summary: Mitochondrial respirometry provides a detailed assessment of oxygen consumption within the electron transport system, yet methods detailing respiration from non-invasive samples remain limited. Here, we present a protocol for measuring mitochondrial respiration in cultured buccal cells. We…
-
Artikel Jurnal
Factors predicting general health concerns and atypical behaviours in children with prenatal alcohol exposure and other adverse exposures
BackgroundPrenatal alcohol exposure (PAE) can have significant negative consequences on the health outcomes of children. Children with PAE often experience other prenatal and postnatal adverse exposures. Increased rates of general health concerns and atypical behaviours are seen in both children…
-
Artikel Jurnal
Transdiagnostic clinical correlates for behaviors of concern in pediatric neurodevelopmental disorders: a retrospective chart review and machine learning analysis
IntroductionBehaviors of concern, such as aggression and self-injury, are common in children with neurodevelopmental disorders and contribute substantially to caregiver stress and health system burden. However, most evidence on behaviors is drawn from diagnostically homogeneous samples, limiting…
-
Artikel Jurnal
Co-designing Nova Sleepcare: identifying priority areas for implementation
BackgroundSleep problems are common in youth with neurodevelopmental disorders and directly contribute to behaviors of concern. While behavioral sleep education improves both issues, a disconnect exists between research and clinical reality: evidence-based sleep interventions are mainly delivered…
-
Artikel Jurnal
Co-designing Nova Sleepcare: exploring in-clinic, physician-delivered sleep education
IntroductionYouth with neurodevelopmental disorders (NDD) frequently experience behaviors of concern (BoC), such as aggression or self-injury, often exacerbated by sleep disturbances. Sleep education can improve sleep in pediatric populations, but existing interventions rarely fit into routine…
-
Artikel Jurnal
Early Onset Diffusion Abnormalities in Refractory Headache Disorders
ObjectiveThis study sought to determine if individuals with medically refractory migraine headache have volume or diffusion abnormalities on neuroimaging compared to neurotypical individuals.BackgroundNeuroimaging biomarkers in headache medicine continue to be limited. Early prediction of medically…
-
Artikel Jurnal
Cerebral volume and diffusion MRI changes in children with sensorineural hearing loss
Purpose: Sensorineural hearing loss (SNHL) is the most prevalent congenital sensory deficit in children. Information regarding underlying brain microstructure could offer insight into neural development in deaf children and potentially guide therapies that optimize language development. We sought…