4 hasil untuk "Seth D. Rhoades"

Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record

Jacob J. Hughey; Seth D. Rhoades; Darwin Y. Fu dkk.

BMC Genomics, Vol. 20 No. 1 · 2019 · Inggris · DOAJ Scopus

Abstract Background The growth of DNA biobanks linked to data from electronic health records (EHRs) has enabled the discovery of numerous associations between genomic variants and clinical phenotypes. Nonetheless, although clinical data are generally longitudinal, standard approaches for detecting…

Glucose is dynamically regulated by time of day in humans and Drosophila

Dania M. Malik; Pinky Kain; Seth D. Rhoades dkk.

PLOS Biology, Vol. 24 No. 4 · 2026 · Inggris · PLOS Scopus

Biological clocks shape metabolism, but how circadian programs govern nutrient processing is unclear. Here, using human metabolomics and 13C6-glucose tracing in Drosophila, we delineate previously under characterized daily oscillations in glucose-derived metabolic networks, providing a mechanistic…

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Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism

Annie L. Hsieh; Xiangzhong Zheng; Zhifeng Yue dkk.

Cell Reports, Vol. 29 No. 7 · 2019 · Inggris · DOAJ Scopus

Summary: Drosophila Myc (dMyc) is highly conserved and functions as a transcription factor similar to mammalian Myc. We previously found that oncogenic Myc disrupts the molecular clock in cancer cells. Here, we demonstrate that misregulation of dMyc expression affects Drosophila circadian behavior…