22 hasil untuk "Stephan Ellmann"
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Artikel Jurnal
Multimodal imaging of bone metastases: From preclinical to clinical applications
Metastases to the skeletal system are commonly observed in cancer patients, highly affecting the patients' quality of life. Imaging plays a major role in detection, follow-up, and molecular characterisation of metastatic disease. Thus, imaging techniques have been optimised and combined in a…
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Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology
Objectives: In human chronic kidney disease (CKD) the extent of renal tubulointerstitial fibrosis correlates with progressive loss of renal function. However, fibrosis can so far only be assessed by histology of kidney biopsies. Magnetic resonance imaging (MRI) can provide information about tissue…
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Correction: Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology
[This corrects the article DOI: 10.1371/journal.pone.0200259.].
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Diagnostic value of 3D dynamic contrast-enhanced magnetic resonance imaging in lymph node metastases of head and neck tumors: a correlation study with histology
Background Accurate staging of cervical lymph nodes (LN) is pivotal for further clinical management of patients with head and neck cancer. Functional magnetic resonance imaging (MRI) such as three-dimensional (3D) dynamic contrast-enhanced (DCE) acquisition might improve the diagnosis of cervical…
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Influence of Different Antioxidants on X-Ray Induced DNA Double-Strand Breaks (DSBs) Using γ-H2AX Immunofluorescence Microscopy in a Preliminary Study
Background: Radiation exposure occurs in X-ray guided interventional procedures or computed tomography (CT) and γ-H2AX-foci are recognized to represent DNA double-strand breaks (DSBs) as a biomarker for radiation induced damage. Antioxidants may reduce the induction of γ-H2AX-foci by binding free…
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Application of machine learning algorithms for multiparametric MRI-based evaluation of murine colitis
Magnetic resonance imaging (MRI) allows non-invasive evaluation of inflammatory bowel disease (IBD) by assessing pathologically altered gut. Besides morphological changes, relaxation times and diffusion capacity of involved bowel segments can be obtained by MRI. The aim of this study was to assess…
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ADP Ribosylation by PARP-1 Suppresses HOXB7 Transcriptional Activity
Interactions with cofactors regulate transcriptional activity and also help HOX proteins to achieve the specificity required for transcriptional regulation of target genes. In this study, we describe a novel protein/protein interaction of HOXB7 with poly (ADP-ribose) polymerase-1 (PARP-1) that…
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Prognostic Value of CTA-Derived Left Ventricular Mass in Neonates with Congenital Heart Disease
For therapeutic decisions regarding uni- or biventricular surgical repair in congenital heart disease (CHD), left ventricular mass (LVM) is an important factor. The aim of this retrospective study was to determine the LVM of infants with CHD in thoracic computed tomography angiographies (CTAs) and…
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Implementation of machine learning into clinical breast MRI: Potential for objective and accurate decision-making in suspicious breast masses
We investigated whether the integration of machine learning (ML) into MRI interpretation can provide accurate decision rules for the management of suspicious breast masses. A total of 173 consecutive patients with suspicious breast masses upon complementary assessment (BI-RADS IV/V: n = 100/76)…
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Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner
Interference with autoimmune-mediated cytokine production is a key yet poorly developed approach to treat autoimmune and inflammatory diseases such as rheumatoid arthritis. Herein, we show that soluble CD83 (sCD83) enhances the resolution of autoimmune antigen-induced arthritis (AIA) by strongly…
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Diagnostic performance of AI-powered prostate MRI against biopsy ground truth: quasi-continuous risk scoring versus fixed PI-RADS thresholds
Abstract Background Multiparametric prostate MRI is central to prostate cancer (PCa) diagnostics, yet PI-RADS interpretation suffers from inter-reader variability. This study aimed to evaluate a commercial AI algorithm for cancer detection in prostate MRI against histopathology, comparing its…
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Contemporary 0.55 T MRI to visualize interstitial lung disease – An exploratory study
Purpose: To evaluate the feasibility of contemporary 0.55 T MRI for visualizing interstitial lung disease (ILD) compared to high-resolution computed tomography (HRCT) in an exploratory first-experience study. Materials and methods: Thirty participants (mean age 60 ± 13 years; 13 females) with…
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Contemporary 0.55 T MRI for Lung Disease Assessment in Children and Young Adults with Cystic Fibrosis: A Proof-of-Concept Study
Background: Lung surveillance in cystic fibrosis (CF) relies on chest radiography (CR) despite cumulative radiation. Low-field MRI may be a radiation-free alternative for children and young adults. Methods: We prospectively compared 0.55 T MRI and CR in 28 same-day examinations of 22 people with CF…
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How COVID-19 kick-started online learning in medical education—The DigiMed study
Background: The coronavirus disease 2019 (COVID-19) pandemic led to far-reaching restrictions of social and professional life, affecting societies all over the world. To contain the virus, medical schools had to restructure their curriculum by switching to online learning. However, only few medical…