25 hasil untuk "Steven Kerr"
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Artikel Jurnal
Introduction to secret sharing based secure multiparty computation in health data
Background Joint analyses across multiple health datasets can increase statistical power and improve the generalisability of research findings. However, limitations on data sharing often prevent researchers from fully realising these benefits. Existing approaches such as federated analytics involve…
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Artikel Jurnal
Enabling health data analyses across multiple private datasets with no information sharing using secure multiparty computation
The UK’s health datasets are among the most comprehensive and inclusive globally, enabling groundbreaking research during the COVID-19 pandemic. However, restrictions on data sharing between secure data environments (SDEs) imposed limitations on the ability to carry out joint analyses across…
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Artikel Jurnal
The economic burden of COVID-19 undervaccination: costs of hospitalisation, ICU admission, and death in Scotland
Abstract The COVID-19 pandemic has imposed substantial financial and operational pressures on healthcare systems globally. While vaccines were known to reduce severe outcomes, their broader economic impacts, especially in publicly funded health systems, requires clearer quantification. This study…
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Artikel Jurnal
Retrospective cohort study to evaluate medication use in patients hospitalised with COVID-19 in Scotland: protocol for a national observational study
Introduction COVID-19 has caused millions of hospitalisations and deaths globally. A range of vaccines have been developed and are being deployed at scale in the UK to prevent SARS-CoV-2 infection, which have reduced risk of infection and severe COVID-19 outcomes. Those with COVID-19 are now being…
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Artikel Jurnal
External validation of the QCovid 2 and 3 risk prediction algorithms for risk of COVID-19 hospitalisation and mortality in adults: a national cohort study in Scotland
Objective The QCovid 2 and 3 algorithms are risk prediction tools developed during the second wave of the COVID-19 pandemic that can be used to predict the risk of COVID-19 hospitalisation and mortality, taking vaccination status into account. In this study, we assess their performance in…
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Artikel Jurnal
Common protocol for validation of the QCOVID algorithm across the four UK nations
Introduction The QCOVID algorithm is a risk prediction tool for infection and subsequent hospitalisation/death due to SARS-CoV-2. At the time of writing, it is being used in important policy-making decisions by the UK and devolved governments for combatting the COVID-19 pandemic, including…
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Artikel Jurnal Teks lengkap
Severity of omicron variant of concern and effectiveness of vaccine boosters against symptomatic disease in Scotland (EAVE II): a national cohort study with nested test-negative design
BACKGROUND: Since its emergence in November, 2021, in southern Africa, the SARS-CoV-2 omicron variant of concern (VOC) has rapidly spread across the world. We aimed to investigate the severity of omicron and the extent to which booster vaccines are effective in preventing symptomatic infection…
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Artikel Jurnal
Deriving and validating a risk prediction model for long COVID-19: protocol for an observational cohort study using linked Scottish data
Introduction COVID-19 is commonly experienced as an acute illness, yet some people continue to have symptoms that persist for weeks, or months (commonly referred to as ‘long-COVID’). It remains unclear which patients are at highest risk of developing long-COVID. In this protocol, we describe plans…
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Artikel Jurnal
Ethnic and social inequalities in COVID-19 outcomes in Scotland: protocol for early pandemic evaluation and enhanced surveillance of COVID-19 (EAVE II)
Introduction Evidence from previous pandemics, and the current COVID-19 pandemic, has found that risk of infection/severity of disease is disproportionately higher for ethnic minority groups, and those in lower socioeconomic positions. It is imperative that interventions to prevent the spread of…
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Artikel Jurnal
Second-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland
Here, Simpson et al. analyze data from 3.6 million COVID-19 vaccine second doses (ChAdOx1 and BNT162b2) in Scotland for risk of thrombocytopenic, thromboembolic and hemorrhagic events. Borderline increased risks of immune thrombocytopenic purpura and cerebral venous sinus thrombosis were found for…
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Artikel Jurnal
VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis
CX3CR1 has been identified as a highly attractive target for several therapeutic interventions. Despite this potential, no potent antagonists, either small molecule or monoclonal antibody, have been identified. Here we describe the lead finding and engineering approach that lead to the…
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Artikel Jurnal
Prevalence and risk factors for long COVID among adults in Scotland using electronic health records: a national, retrospective, observational cohort studyResearch in context
Summary: Background: Long COVID is a debilitating multisystem condition. The objective of this study was to estimate the prevalence of long COVID in the adult population of Scotland, and to identify risk factors associated with its development. Methods: In this national, retrospective…
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Artikel Jurnal Teks lengkap
Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study
BACKGROUND: The BNT162b2 mRNA (Pfizer-BioNTech) and ChAdOx1 nCoV-19 (Oxford-AstraZeneca) COVID-19 vaccines have shown high efficacy against disease in phase 3 clinical trials and are now being used in national vaccination programmes in the UK and several other countries. Studying the real-world…
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Artikel Jurnal
BNT162b2 COVID-19 vaccination uptake, safety, effectiveness and waning in children and young people aged 12–17 years in Scotland
Summary: Background: The two-dose BNT162b2 (Pfizer-BioNTech) vaccine has demonstrated high efficacy against COVID-19 disease in clinical trials of children and young people (CYP). Consequently, we investigated the uptake, safety, effectiveness and waning of the protective effect of the BNT162b2…
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Artikel Jurnal
Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity
Abstract Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the $$S/F$$ S / F ratio. Because of the ceiling effect in…
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Artikel Jurnal Teks lengkap
First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales
…to the general public. In a pooled self-controlled case series study, Steven Kerr and colleagues assess the association between first dose ChAdOx1 and BNT162b2 COVID-19 vaccination with cerebral venous sinus thrombosis in England, Scotland and Wales. Why was this study done?: What did the…
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