9 hasil untuk "Virginie Adam"
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Artikel Jurnal
APP family member dimeric complexes are formed predominantly in synaptic compartments
Abstract Background The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and heterotypic dimers and exhibit overlapping functions. Results We…
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Artikel Jurnal
A mixed method feasibility and acceptability study of a flexible intervention based on acceptance and commitment therapy for patients with cancer
ProposeThis study aimed to propose an innovative, open, and circular program that combines acceptance and commitment therapy (ACT) and mindfulness practices. We assessed its feasibility, acceptability, and first signs of its effect on psychological wellbeing in cancer support treatment.MethodsA…
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Evolving incidence patterns for locally advanced operable breast cancer by receptor status: SEER 2010–2021
Abstract Tumor biologic risk has replaced anatomic disease burden for guiding chemotherapy use in HR-positive, early-stage breast cancer. Recent surgical trials support less frequent axillary lymph node dissection, potentially impacting incidence of N2-3 diagnoses. As the field considers applying…
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Climate change impacts and sustainability integration among breast international group members
Background: Integration of sustainability measures into clinical research would translate into less healthcare related climate impacts. Methods: We assessed climate change impacts, existing sustainability engagement, and challenges and facilitators to climate change mitigation strategies among…
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Conversational hypnosis versus standard of care to reduce anxiety in patients undergoing marker placement under radiographic control prior to breast cancer surgery: A randomized, multicenter trial
BackgroundSurgery is a cornerstone of breast cancer management. Prior to surgery, a wire marker is placed at the site of the tumor, to enable the surgeon to accurately localize the lesion during later surgery. This procedure can generate considerable anxiety for many patients. We investigated the…
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Artikel Jurnal
The Breast International Group (BIG) Patient Partnership: Embedding meaningful patient involvement in the design and conduct of breast cancer clinical research
Involving those with a lived experience of the relevant condition in the design of clinical research ensures that studies address real-world needs and priorities, enabling more relevant, ethical, and impactful outcomes. In 2019, the Breast International Group (BIG) established the BIG Patient…
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Advancing equitable access to innovation in breast cancer
This manuscript critically examines the challenges associated with the design and conduct of academic global breast cancer trials outside the influence of pharmaceutical companies, leveraging insights from the Breast International Group (BIG). In the past 4 decades significant declines in breast…
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Artikel Jurnal
Invest where impact begins: recommendations from Breast Cancer Research Foundation Early Career Investigator Working Group (Part 1 of 2)
Early-career investigators face growing challenges: dwindling public funding, limited trial leadership opportunities, systemic mentorship barriers, and widening global disparities. At the 20th Breast International Group (BIG) – NCI National Clinical Trials Network (NCTN) annual meeting, four key…