9 results for "Volkmar Lessmann"

Cholesterol depletion inhibits BDNF-dependent spike timing-dependent plasticity at thalamo-amygdala synapses

Thomas Munsch; Susanne Meis; Volkmar Lessmann

Frontiers in Cellular Neuroscience, Vol. 20 · 2026 · English · DOAJ Scopus

The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a key regulator of synaptic plasticity in hippocampus and cortex of mammalian brains. In the lateral nucleus of the amygdala (LA), BDNF is involved in the control of long-term potentiation (LTP). Here, we show that BDNF is…

Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in Young Adults – A Randomized Controlled Feasibility Study

Andreas Becke; Patrick Müller; Milos Dordevic et al.

Frontiers in Physiology, Vol. 9 · 2018 · English · DOAJ Scopus

Background: The results from animal and human research indicate that acute intermittent hypoxia can enhance brain-derived neurotrophic factor (BDNF) plasma levels and gene expression. As BDNF is known to promote the differentiation of new neurons and the formation of synapses, it has been proposed…

A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity

Zenghui Teng; Georgia-Ioanna Kartalou; Sushma Dagar et al.

Cell Death Discovery, Vol. 9 No. 1 · 2023 · English · DOAJ Scopus

Abstract Synaptotoxic Aβ oligomers are thought to play a major role in the early pathology of Alzheimer´s disease (AD). However, the molecular mechanisms involved in Aβ-induced synaptic dysfunction and synapse damage remain largely unclear. Previously, Aβ synaptotoxicity has been reported to be…

Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly

Kathrin Rehfeld; Angie Lüders; Anita Hökelmann et al.

PLOS ONE, Vol. 13 No. 7 · 2018 · English · PLOS Scopus

Animal research indicates that a combination of physical activity and sensory enrichment has the largest and the only sustaining effect on adult neuroplasticity. Dancing has been suggested as a human homologue to this combined intervention as it poses demands on both physical and cognitive…

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Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons

Bianca Seifert; Robert Eckenstaler; Raik Rönicke et al.

Neural Plasticity, Vol. 2016 · 2016 · English · DOAJ Scopus

The neurotrophin brain derived neurotrophic factor (BDNF) is an important growth factor in the CNS. Deficits in transport of this secretory protein could underlie neurodegenerative diseases. Investigation of disease-related changes in BDNF transport might provide insights into the cellular…

Editorial: Synaptopathies: from bench to bedside

Clive R. Bramham; Volkmar Lessmann; Anthony J. Hannan et al.

Frontiers in Synaptic Neuroscience, Vol. 15 · 2023 · English · DOAJ Scopus

HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Syed Ahsan Raza; Anne Albrecht; Gürsel Çalışkan et al.

Nature Communications, Vol. 8 No. 1 · 2017 · English · DOAJ Scopus

Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST+ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY+ hilar…

Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology

Merel O. Mol; Suzanne S. M. Miedema; Shamiram Melhem et al.

Acta Neuropathologica Communications, Vol. 10 No. 1 · 2022 · English · DOAJ Scopus

Abstract Semantic dementia (SD) is a clinical subtype of frontotemporal dementia consistent with the neuropathological diagnosis frontotemporal lobar degeneration (FTLD) TDP type C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Despite this striking clinicopathological…