51 hasil untuk "Wan-Yu Lin"
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Artikel Jurnal
Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE. These epigenetic clocks were mainly developed by individuals of European or…
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Artikel Jurnal
The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants
Regular physical exercise is recommended to reduce the risk of obesity. However, it remains unclear which activities are more effective in preventing obesity. In this study, five obesity indices and lifestyle factors of 33,731 Taiwan Biobank adults were measured/collected twice with a mean time…
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Artikel Jurnal
Searching for gene-gene interactions through variance quantitative trait loci of 29 continuous Taiwan Biobank phenotypes
Introduction: After the era of genome-wide association studies (GWAS), thousands of genetic variants have been identified to exhibit main effects on human phenotypes. The next critical issue would be to explore the interplay between genes, the so-called “gene-gene interactions” (GxG) or epistasis…
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Artikel Jurnal
Mining for gene-environment and gene-gene interactions: parametric and non-parametric tests for detecting variance quantitative trait loci
IntroductionDetection of variance quantitative trait loci (vQTL) can facilitate the discovery of gene-environment (GxE) and gene-gene interactions (GxG). Identifying vQTLs before direct GxE and GxG analyses can considerably reduce the number of tests and the multiple-testing penalty.MethodsDespite…
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Artikel Jurnal
Modifiable lifestyle factors and 4.9-Year changes in phenotypic age in the Taiwan biobank
IntroductionPhenotypic age (PhenoAge) is a composite biomarker that reflects biological aging by integrating indicators of immune, metabolic, liver, and kidney function.MethodsUsing 4.9 years of follow-up data from 69,462 participants in the Taiwan Biobank, this study investigated lifestyle and…
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Artikel Jurnal
A large-scale observational study linking various kinds of physical exercise to lipoprotein-lipid profile
Background Being a major cardiovascular risk factor, dyslipidemia is a critical problem in public health. Recommendations in performing regular physical exercise are important to prevent dyslipidemia. Methods Based on a discovery cohort with 27,735 subjects and a replication cohort with 67,512…
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Artikel Jurnal
Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants
Abstract Background Obesity adversely influences the central nervous system and cognitive functions. However, the relationship between various obesity indicators and cognitive performance remains controversial. It is unclear which obesity indicator is more relevant to cognitive impairment. Methods…
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Artikel Jurnal Teks lengkap
Association testing of clustered rare causal variants in case-control studies.
Biological evidence suggests that multiple causal variants in a gene may cluster physically. Variants within the same protein functional domain or gene regulatory element would locate in close proximity on the DNA sequence. However, spatial information of variants is usually not used in current…
Juga tersedia di: PLOS
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Artikel Jurnal Teks lengkap
Adaptive combination of P-values for family-based association testing with sequence data.
Family-based study design will play a key role in identifying rare causal variants, because rare causal variants can be enriched in families with multiple affected subjects. Furthermore, different from population-based studies, family studies are robust to bias induced by population substructure…
Juga tersedia di: PLOS
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Artikel Jurnal Teks lengkap
Presenting the Uncertainties of Odds Ratios Using Empirical-Bayes Prediction Intervals
Quantifying exposure-disease associations is a central issue in epidemiology. Researchers of a study often present an odds ratio (or a logarithm of odds ratio, logOR) estimate together with its confidence interval (CI), for each exposure they examined. Here the authors advocate using the…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Improving Power of Genome-Wide Association Studies with Weighted False Discovery Rate Control and Prioritized Subset Analysis
The issue of large-scale testing has caught much attention with the advent of high-throughput technologies. In genomic studies, researchers are often confronted with a large number of tests. To make simultaneous inference for the many tests, the false discovery rate (FDR) control provides a…
Juga tersedia di: DOAJ
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Artikel Jurnal
Jejunal Tuberculosis: Incidental Finding on an FDG-PET Scan
A 32-year-old male had suffered from persistent dull epigastric pain, constipation, postprandial vomiting, and body-weight loss for 2 months. An abdominal computed tomography (CT) scan showed thickening of the proximal jejunal wall. He was also referred to our center for an…
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Artikel Jurnal
Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes
Abstract Background Smoking can lead to the deterioration of lung function and susceptibility to diabetes. Recently, smoking was found to induce DNA methylation (DNAm) changes in some cytosine-phosphate-guanine sites (CpGs). As linear combinations of DNAm levels of aging-related CpGs, five measures…
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Artikel Jurnal
The impact of tooth loss on the risk of cognitive impairment among community-dwelling older adults: a prospective cohort study
Abstract Background Oral health problems, such as tooth loss, are common among older adults and have been linked to chronic diseases and functional decline. However, evidence based on rigorous longitudinal designs and large-scale population databases remains limited. This study aimed to investigate…
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Artikel Jurnal
The impact of healthy behaviors and physical activity on preventing cognitive impairment among older residents in Taipei
Background: With the rapid aging of the population, the prevalence of dementia among older adults has been increasing. This study aims to investigate the impact of healthy lifestyle behaviors and physical activity on the attenuation of cognitive decline in older adults. Methods: This study…
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Artikel Jurnal
Causal effects of cardiovascular health on five epigenetic clocks
Abstract Background This work delves into the relationship between cardiovascular health (CVH) and aging. Previous studies have shown an association of ideal CVH with a slower aging rate, measured by epigenetic age acceleration (EAA). However, the causal relationship between CVH and EAA has…