9 results for "Wing-Yu Fu"

Cdk5 Phosphorylates a Component of the HDAC Complex and Regulates Histone Acetylation during Neuronal Cell Death

Amy K.Y. Fu; Kwok-Wang Hung; Hovy Ho-Wai Wong et al.

Neurosignals, Vol. 21 No. 1-2 · 2012 · English · DOAJ Scopus

Cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for regulating neural development and neuronal survival. Dysregulation of Cdk5 is associated with abnormal expression of cell cycle-related proteins during neuronal apoptosis. We have previously found that…

p35 Regulates the CRM1-Dependent Nucleocytoplasmic Shuttling of Nuclear Hormone Receptor Coregulator-Interacting Factor 1 (NIF-1)

Xiao-Su Zhao; Wing-Yu Fu; Winnie W. Y. Chien et al.

PLoS ONE, Vol. 9 No. 10 · 2014 · English · PLOS Scopus

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Cdk5 activity is controlled by its specific activators: p35 or…

Also available at: DOAJ

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling

Yu Chen; Zhuoyi Liang; Erkang Fei et al.

PLOS ONE, Vol. 10 No. 7 · 2015 · English · PLOS Scopus

During development, scaffold proteins serve as important platforms for orchestrating signaling complexes to transduce extracellular stimuli into intracellular responses that regulate dendritic spine morphology and function. Axin (“axis inhibitor”) is a key scaffold protein in canonical Wnt…

Also available at: DOAJ

IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease

Shun-Fat Lau; Congping Chen; Wing-Yu Fu et al.

Cell Reports, Vol. 31 No. 3 · 2020 · English · DOAJ Scopus

Summary: Impairment of microglial clearance activity contributes to beta-amyloid (Aβ) pathology in Alzheimer’s disease (AD). While the transcriptome profile of microglia directs microglial functions, how the microglial transcriptome can be regulated to alleviate AD pathology is largely unknown…

Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model

Jackie K. Y. Lau; Min Tian; Yang Shen et al.

Scientific Reports, Vol. 11 No. 1 · 2021 · English · DOAJ Scopus

Abstract Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no disease-modifying treatment. AD progression is characterized by cognitive decline, neuroinflammation, and accumulation of amyloid-beta (Aβ) and neurofibrillary tangles in the brain, leading to neuronal and glial…

Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs

Shuo Gu; Wing-Yu Fu; Amy K. Y. Fu et al.

Scientific Reports, Vol. 8 No. 1 · 2018 · English · DOAJ Scopus

Abstract The receptor tyrosine kinase, erythropoietin-producing hepatocellular A4 (EphA4), was recently identified as a molecular target for Alzheimer’s disease (AD). We found that blockade of the interaction of the receptor and its ligands, ephrins, alleviates the disease phenotype in an AD…

DeepPlaque: a scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer’s disease

Hiu Yi Wong; Cheng Jin; Sze Long Yuen et al.

EMBO Molecular Medicine, Vol. 18 No. 9 · 2026 · English · DOAJ Scopus

Abstract Histological analysis is essential for understanding disease pathology and the microenvironment, particularly in Alzheimer’s disease (AD), characterized by beta-amyloid (Aβ) plaques that exist as diffuse, fibrillar, and core species, with distinct toxicity levels. However, accurate…