13 results for "Zil-e- Rubab"
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Journal Article
Genetic Impact of Second Hand Cigarette Smoke
Second hand smoke is a complex mixture of more than 4000 chemical compounds that are generated during the burning of tobacco products and affects all those who are exposed to smokers in a closed environment either at home or work place. This mixture contains numerous irritants and toxicants which…
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CHIP: A Newfangled Peril For Coronary Heart Disease In Pakistan
Certain somatic mutations are capable to confer a selective benefit to blood stem cells become much more common with aging1. This state was entitled “clonal hematopoiesis of indeterminate potential,” (CHIP), and found that it upsurges the risk of developing a blood cancer more than 10-fold and it…
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IS tRNA DRIVING BREAST CANCER PROGRESSION?
This critical research periodical is mainly based on critical review of research article titled ‘Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression published in Cell by Goodarzi et al1. According to Globocan, 2008 report2, breast is among the leading site of new…
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FUT8: AN EMERGING DRIVER OF METASTASIS
This critical research periodical is mainly based on critical review of research article titled “A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis” published in Cancer Cell by Agrawal et al1. Glycosylation is the distinct cell and microenvironment relatedmechanism…
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Journal Article Full text
Harlequin fetus born from Consanguinity: A deleterious case report
Harlequin Ichthyosis (HI) is a dreadful skin disorder with steady rise of cases with prolonged survival. Harlequin fetus follows an autosomal recessive pattern with the incidence of 1in 300,000 live births. In the succeeding case report, a male child was born with keratinized and kaleidoscopic…
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Dysregulated epidermal growth factor and tumor growth factor-beta receptor signaling through GFAP-ACTA2 protein interaction in liver fibrosis
OBJECTIVE: Viral hepatitis is associated with high morbidity and mortality. Identification of biological pathways involved in hepatic fibrosis resulting from chronic hepatitis C are essential for better management of patients. Constructing the HCV-human protein interaction network through…
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Understanding the Fat Gene Obesity Common Variant FTO rs9939609
Obesity, attributable to the interaction of genetic makeup, lifestyle and environment Factors are a multifactorial disease. However, not all people with similar genetics or same environmental setup become obese. Currently, extensive research is being conducted regarding increases in the prevalence…
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Problem Based Learning Development Program at Bahria University Medical and Dental College
ABSTRACT Background: Problem based learning (PBL) introduced by Howard Barrows at McMaster University in 1969 is generaliy regarded as an effective learning strategy with an active process of personal cognitive construction. Many medical colleges have adapted this methodology as partial or complete…
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Journal Article
Pattern Of Substance AbuseIn Multi Ethnic GroupsIn . Different Localities Of Karachi
ABSTRACT Background: Substance abuse is a growing endemic in our population. Gutka, areka nut, cigarette, paan and niswar are being the five most commonaddictive in current use. Through this study the patterns of abusein different ethnicities and the reason forinitiation of different additive’ was…
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Human papilloma virus 16/18: Fabricator of trouble in oral squamous cell carcinoma
Aim: To find out the association between Human Papilloma Virus (HPV) genotypes 16/18 in Pakistani patients with oral squamous cell carcinoma (OSCC). Methods: DNA from oral rinse of 300 subjects was taken. The subjects included 100 cases with OSCC and 200 controls. Samples were analyzed by both…
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Knowledge, attitudes, and practices against the growing threat of COVID-19 among medical students of Pakistan
Background: On account of the COVID-19 pandemic, many changes have been implicated in university medical students. We are cognizant that pandemic can be controlled with dedicated contributions from all involved in the healthcare profession. Therefore, it is important to know the pandemic and…
Also available at: DOAJ
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Journal Article
Role of OX40 and its ligand as costimulatory modulators in cancer immunotherapy
Body's defence mechanism has ability to combat tumour cells but tumour cells can circumvent immune system in order to flourish. Therefore, current research focuses on reinvigorating immune system to combat against extensive range of human malignancies through immunotherapy. Recently, immuno-therapy…