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Artikel Jurnal Teks lengkap
Interplay of oxidative stress, cellular communication and signaling pathways in cancer
Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays a critical role in the development of cancer by affecting genomic stability and…
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The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review
Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the environment and human health. This review is aimed at discussing the state-of-the-art progress on the recent developments on the toxicity of mercury and its chemical compounds. More than 210 recent…
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Cell–cell communication: new insights and clinical implications
Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintenance, and physiological regulation. Cells communicate…
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The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity
The NHGRI-EBI GWAS Catalog serves as a vital resource for the genetic research community, providing access to the most comprehensive database of human GWAS results. Currently, it contains close to 7 000 publications for >15 000 traits, from which more than 625 000 lead associations have been…
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Innovative Adsorbents for Pollutant Removal: Exploring the Latest Research and Applications
The growing presence of diverse pollutants, including heavy metals, organic compounds, pharmaceuticals, and emerging contaminants, poses significant environmental and health risks. Traditional methods for pollutant removal often face limitations in efficiency, selectivity, and sustainability. This…
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Human-AI collaboration patterns in AI-assisted academic writing
Artificial Intelligence (AI) has increasingly influenced higher education, notably in academic writing where AI-powered assisting tools offer both opportunities and challenges.Recently, the rapid growth of generative AI (GAI) has brought its impacts into sharper focus, yet the dynamics of its…
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GENCODE 2025: reference gene annotation for human and mouse
GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as new technologies and methodologies allow us to catalog the genome at ever-increasing granularity. In particular, long-read transcriptome sequencing enables…
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Preparation and Identification of Magnetic Iron Nanoparticle based on a Natural Hydrogel and its Performance in Targeted Drug Delivery
Billions of dollars are spent annually in the world to treat and investigate problems caused by drug side effects. According to the estimates of health researchers, about 40%of people who take medicine suffer from side effects. In this way, the necessity of using a targeted system in order to…
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Evaluation of clinical prediction models (part 2): how to undertake an external validation study
External validation studies are an important but often neglected part of prediction model research. In this article, the second in a series on model evaluation, Riley and colleagues explain what an external validation study entails and describe the key steps involved, from establishing a high…
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Using and Interpreting Fixed Effects Models
ABSTRACT Fixed effects (FE) have emerged as a ubiquitous and powerful tool for eliminating unwanted variation in observational accounting studies. Unwanted variation is plentiful in accounting research because we often use rich data to test precise hypotheses derived from abstract theories. By…
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Tailoring d-band center of high-valent metal-oxo species for pollutant removal via complete polymerization
Polymerization-driven removal of pollutants in advanced oxidation processes (AOPs) offers a sustainable way for the simultaneous achievement of contamination abatement and resource recovery, supporting a low-carbon water purification approach. However, regulating such a process remains a great…
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Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy
The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the…
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A Review of Precision Irrigation Water-Saving Technology under Changing Climate for Enhancing Water Use Efficiency, Crop Yield, and Environmental Footprints
Water is considered one of the vital natural resources and factors for performing short- and long-term agricultural practices on Earth. Meanwhile, globally, most of the available freshwater resources are utilized for irrigation purposes in agriculture. Currently, many world regions are facing…
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Underestimated burden of per- and polyfluoroalkyl substances in global surface waters and groundwaters
Abstract Per- and polyfluoroalkyl substances (PFAS) are a class of fluorinated chemicals used widely in consumer and industrial products. Their human toxicity and ecosystem impacts have received extensive public, scientific and regulatory attention. Regulatory PFAS guidance is rapidly evolving…
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Development of a Low-Cost Banana Fiber Extractor
Banana fiber is an underutilized natural resource with potential for industrial applications and value addition at the smallholder farm level. Traditional manual methods for extracting fibers from banana plant wastes are inefficient and labour-intensive. This limits opportunities for rural…
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Observation of time-reversal symmetry breaking in the band structure of altermagnetic RuO 2
Altermagnets are an emerging elementary class of collinear magnets. Unlike ferromagnets, their distinct crystal symmetries inhibit magnetization while, unlike antiferromagnets, they promote strong spin polarization in the band structure. The corresponding unconventional mechanism of time-reversal…
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Development of a Cost-Effective Coconut Dehusking Machine
This study aimed to develop an affordable mechanized solution to address this challenge.A coconut dehusking machine prototype was designed, fabricated, and tested. It consists of a rigid steel frame, two counter- rotating cylindrical drums fitted with spikes, an electric motor, a V-belt drive…
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How to build the virtual cell with artificial intelligence: Priorities and opportunities
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to create an AI virtual cell (AIVC), a multi-scale, multi-modal large-neural-network-based…
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CZ CELLxGENE Discover: a single-cell data platform for scalable exploration, analysis and modeling of aggregated data
Hundreds of millions of single cells have been analyzed using high-throughput transcriptomic methods. The cumulative knowledge within these datasets provides an exciting opportunity for unlocking insights into health and disease at the level of single cells. Meta-analyses that span diverse datasets…
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The Role of Pro-Inflammatory Cytokines in the Pathogenesis of Cardiovascular Disease
With cardiovascular disease (CVD) being a primary source of global morbidity and mortality, it is crucial that we understand the molecular pathophysiological mechanisms at play. Recently, numerous pro-inflammatory cytokines have been linked to several different CVDs, which are now often considered…
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