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The identification of metabolites from gut microbiota in HPV infection via network pharmacology
Human papillomavirus (HPV) infection continues to pose a significant global health challenge. Although gut microbial metabolites have been associated with HPV infection, the mechanisms underlying this relationship remain inadequately understood. A network pharmacology approach was utilized to…
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Unsupervised industrial image defect detection based on autoencoder and GANs
In the process of intelligentization in modern manufacturing, especially in industrial fields such as automobile manufacturing, semiconductor production, and electronic product assembly, product quality control is crucial. Traditional defect detection methods face problems such as supervised…
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Lightweight blockchain facilitated BIM data management for smart city operation and maintenance
Building Information Modelling (BIM) project operation and maintenance information management in smart cities currently faces challenges like data redundancy, a large number of management and maintenance personnel, and complex processes. Blockchain technology, with its decentralized and…
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Environmental pathogen surveillance in cities without universal piped wastewater infrastructure
Although wastewater surveillance for assessing community health and well-being is now mainstream, most cities in low- and middle-income countries lack conventional wastewater services. In these settings, environmental surveillance beyond conventional wastewater offers the potential to inform public…
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Maternal sleep quality during pregnancy and neonatal outcomes: A study from Riyadh, Saudi Arabia
Background: Poor sleep quality during pregnancy has been increasingly associated with adverse neonatal outcomes and heightened maternal psychological distress. However, evidence from Middle Eastern populations remains limited, particularly in Saudi Arabia where cultural and environmental factors…
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The impact of high fat diet on global protein abundance and fractional synthetic rate in liver and mammary gland of peak lactation ICR mice
Maternal metabolic environment creates the developmental environment for offspring. Previous studies demonstrated high fat (HF) diet increased neonate growth rate during lactation, which related to increased milk lactose content and increased fatty acyl chain length and unsaturation of milk lipids…
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Unveiling the Multifaceted Dynamics of Breast Cancer: A Copula Regression Approach to Modeling and Predicting Outcomes
This study examines the application of flexible copula regression models to analyze the complex interdependencies among clinical variables in breast cancer data. As the most commonly diagnosed cancer and the second leading cause of cancer-related deaths among women worldwide, breast cancer presents…
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Effects of complex training on jump performance and neuromuscular activation in volleyball athletes: A controlled study
This study examined the integrated effects of complex training combining barbell back squats (BBS) and drop jumps (DJ) on jump performance and concentric-phase neuromuscular activation in volleyball athletes. In a randomized controlled design, twenty male volleyball athletes were allocated to an…
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A common network of residue-residue contacts underlies interactions between peptides and HLA class II complex
The formation of a stable antigenic peptide-HLA II (p-HLA class II) complex is a critical early step in the adaptive immune response. In this work, we identify the residue-residue contacts that ‘anchor’ the peptide between the alpha and beta chains of HLA II and examine whether the anchoring…
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Risk factors associated with Shigella diarrhea in 6–35-month-olds: A cross-sectional study, Malawi, 2022–2024
Diarrhea due to Shigella causes 60,000 deaths annually among children under five in low- and middle-income countries. This Enterics for Global Health sub-study examined host, clinical, and environmental factors linked to Shigella-attributable diarrhea in Malawian children and assessed seasonal…
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Reducing alcohol consumption in UK armed forces veterans: Feasibility of using personalized push notifications with AI
This study assessed the feasibility of deploying RationAI, a personalized AI-supported messaging framework, to reduce alcohol consumption among UK Armed Forces veterans. Participants were given DrinksRation, a mobile phone app, and allocated to receive either personalized or generic behavior change…
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Epidemiological and molecular characterization of Rift Valley fever outbreak in livestock in Burundi, May - November 2022
An outbreak of Rift Valley fever (RVF) was officially reported for the first time in Burundi on 10th May 2022. The outbreak originated in the northern provinces and progressively spread to other regions of the country. This study presents (i) epidemiological investigations that were carried out…
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Casein kinase 2-mediated phosphorylation of the splicing factor SF3B3 plays a key role in esophageal squamous cell carcinoma progression
Protein kinases play a crucial role in regulating cellular processes, and their dysregulation is frequently implicated in various diseases, including cancer. Targeting protein kinases represents a promising therapeutic strategy for cancer treatment. Esophageal squamous cell carcinoma (ESCC)…
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Exploring how mothers with a history of intimate partner violence experienced the COVID-19 pandemic in Ontario, Canada
In Canada, approximately 44% of women will experience intimate partner violence (IPV) in their lifetime. Given that the majority of women who face IPV are within childbearing years, IPV often co-occurs with being a mother. While research exists on mothering and IPV, a gap in the literature exists…
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A computer vision approach for the grading of cotton base load ages in measuring the performance of washing machine
The performance testing standards for washing machines specify clear requirements regarding the age of the base load used. To enable non-contact detection of the service life of the test fabric and thereby improve the consistency of washing machine performance test results, this study employed…
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Predicted meta-omics: A potential solution to multi-omics data scarcity in microbiome studies
Imbalances in the gut microbiome have been linked to conditions such as inflammatory bowel disease, diabetes, and cancer. While metagenomics and amplicon sequencing are commonly used to study the microbiome, they do not capture all layers of microbial functions. Other meta-omics data can provide…
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Why do self-referent cues facilitate mathematical word problem-solving? Insights from eye tracking
Associating information with the self enhances processing of that information, with simple text cues like self-referent pronouns (i.e., ‘You’) increasing response speed and accuracy in processing tasks. Research suggests this can be applied in educational contexts, such as children’s mathematical…
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Assessment of peak bone mineral density and its associated factors in Vietnamese adults: A cross-sectional study
Introduction: Osteoporosis is a growing public health concern in Vietnam, yet population-specific reference data for peak bone mineral density (PBD) remain limited. This study aimed to establish a standard PBD dataset and identify factors associated with bone mineral density (BMD) in Vietnamese…
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An automatic weighing device for measuring the consumption of cleaning agents in mechanical cleaning equipment
Objective: This study aims to develop an automatic weighing device based on embedded technology for accurately monitoring the consumption of various cleaning agents during each cleaning cycle of mechanical cleaning equipment used in the Central Sterile Supply Department (CSSD). Methods: The…
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Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer’s Therapy
Alzheimer’s Disease (AD), the dominant form of dementia that evolves with age, involves several mechanisms by which it progresses. The cholinergic hypothesis proposes that the activity of Acetylcholinesterase (AChE) causes the decline of cholinergic neurotransmission, which leads to Alzheimer’s…
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