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Regional Lassa virus lineages select for divergent MHC-I repertoires in Mastomys natalensis rodents
Identifying genes under local adaptation is an essential step to understand the mechanisms of adaptive evolution. Pathogen-mediated selection is expected to enhance host fitness by favouring resistance to locally prevalent pathogens. However, such pathogen-driven adaptation has been documented in…
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SkitoSnack 2.0 - A Bloodmeal Alternative for Anopheles and Aedes Mosquitoes
SkitoSnack, an artificial blood-meal alternative, was developed in 2018 for rearing Aedes aegypti mosquitoes in laboratory culture. This artificial blood-meal diet has a long shelf life and can effectively support the long-term rearing of Ae. aegypti. However, Anopheles mosquitoes often do not…
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Effects of salinity and broad-range antibiotics on oxalate production, transport, and degradation in Poecilia latipinna
Oxalate is an anion that readily binds calcium and is thought to contribute to osmoregulation. This study investigated how environmental salinity influences oxalate homeostasis in euryhaline sailfin mollies (Poecilia latipinna), with a focus on the interplay between microbial symbiosis and host…
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Co-Design of strategies to enhance access to Virtual Urgent Care models by equity-deserving populations
Virtual urgent care (VUC) was introduced in 2020 across the province of Ontario, Canada, during the COVID-19 pandemic to provide urgent care for lower-acuity health needs for patients who did not require in-person care. Persons from equity-deserving populations (EDPs) often face barriers in using…
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Socio-spatial logic of demolition and relocation in urban China
While urban demolition (Chai Qian), a process encompassing housing removal and resident relocation, is a distinctive feature of China’s urban transformation, its underlying socio-spatial logic remains insufficiently understood. This paper extends Henri Lefebvre’s theory to examine the spatial…
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Distinct plasma cytokine and chemokine profiles in severe COVID-19 and septic shock
Background: Severe Coronavirus Disease 2019 (COVID-19) and septic shock are both characterized by dysregulated host immune responses. While similarities and differences in immune responses between COVID-19 and bacterial sepsis have been reported, direct comparative analyses remain limited. This…
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Identification of climate mitigation and adaptation strategies for protection of preharvest food safety: A scoping review
Climate change influences the growth, persistence, and transport of biological and chemical contaminants of preharvest foods. This can drive increases in food- and waterborne illnesses, further burdening public health and agri-food systems. Therefore, effective mitigation and adaptation strategies…
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Comparing regular expression and machine learning approaches to predict immigrant status from primary care electronic medical record data in Ontario, Canada
New immigrants often face barriers when navigating the healthcare system, which can create unmet healthcare needs and contribute to health inequities. Primary care practices, as the gateway to the healthcare system, could use information about their patients’ immigrant status to ensure accessible…
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Safety and effectiveness of stereotactic radiosurgery for larger hemangioblastomas (>2cc): A multi-center retrospective study
Introduction: Hemangioblastomas (HGB) are the most common primary intra-axial tumors in the posterior fossa in adults, with an overall occurrence of 7–10%. They occur sporadically or as part of von Hippel-Lindau (VHL) disease. The role of stereotactic radiosurgery (SRS) as a minimally invasive…
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Variations in Children’s screen time behaviors by weight status among a mostly disadvantaged population
The purpose of this survey study was to comprehensively examine if various types of screen time differed between children with overweight or obesity (OWOB; ≥ 85th BMI percentile) vs. normal weight (NW: < 85th BMI percentile) in a largely socioeconomically disadvantaged population. 739 parent…
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Color outside the lines: How does amoral management influence employees’ creative unethicality?
Existing research has confirmed that amoral management can induce employees to engage in unethical behavior. However, its influence on a specific form of misconduct that involves creativity—namely, creative unethicality—remains unclear. Based on social information processing theory, this study…
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Evaluation of the predictive accuracy of QUICKI and McAuley indices for insulin resistance in adolescents: Insights from a cross-sectional study
Different indirect methods have been developed to assess insulin resistance (IR), though their validation has been limited to adult populations. In this sense, the study aim is to compare the predictive capacity of the McAuley, QUICKI, SPISE indices, and glucose-insulin ratio against insulin…
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Coriander leaf essential oil as an immunomodulator: Enhancing NF-κB -driven RAW246.7 murine macrophages response to Candida albicans
Coriander is a cultivated aromatic herb used as a culinary ingredient and in traditional medicinal treatments worldwide. Coriander essential oil contains various bioactive constituents with antibacterial, antioxidant, and anti-inflammatory effects. The oil also has antifungal activity against…
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Complications and mortality following percutaneous and laparoscopic liver biopsy: A multicenter study in a resource‑limited healthcare system
This study was conducted to assess the incidence and types of complications and mortality following liver biopsy, and to identify independently associated factors that can inform clinical practice in a resource‑limited healthcare system. A retrospective multicenter study was conducted across six…
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Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, with its onset and progression closely linked to neuroinflammation, where abnormal activation and migration of microglia serve as a key pathological process. This study focuses on the regulatory role of gastrodin, the…
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The clinical characteristics and risk factors of steroid-induced ocular hypertension following pars plana vitrectomy
Objective: This study aimed to assess the incidence and risk factors for the development of steroid-induced ocular hypertension (SIOH) following 23-gauge (23G) pars plana vitrectomy. Methods: The clinical data of patients treated with 23G vitrectomy from January 2019 to March 2022 were reviewed…
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Toward compassionate workplaces: Employers’ and employees’ perspectives on serious illness, dying, death, and grief: Findings from a nationwide online survey in Germany
Background: Experiences of serious illness, dying, death, and grief in the workplace significantly affect employee well-being, productivity, and organizational culture. Despite increasing recognition of their importance, there is limited understanding of workplace perspectives in Germany. This…
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Implicit association tests for all: Using iatgen for non-English and offline samples
The Implicit Association Test (IAT) has become an invaluable tool for researchers in many fields. The IAT is a sorting task that measures the strength of automatic associations between targets (e.g., flowers / insects) and attributes (e.g., pleasant / unpleasant). Several programs exist to create…
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Evidence-based action plan for integrating artificial intelligence in an academic medical centre-a multidisciplinary approach
Introduction: As the effectiveness of artificial intelligence (AI) in enhancing various facets of healthcare delivery becomes more apparent, it is anticipated that AI will soon find its way into standard clinical practices, even in low and middle-income countries. The objective of this study was to…
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Enhancing generalizability in classification of peripheral neural recordings with graph neural network
The peripheral nervous system plays a crucial role in facilitating communication between biological systems. However, decoding neural signals from peripheral nerve recordings remains a challenge due to their complex spatiotemporal patterns. In this study, we propose a graph-based learning approach…
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