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Tobacco control policies on cancer prevention in the Eastern Mediterranean Region, 2025–2050: A modeling study
Background: Despite the implementation of control policies, smoking prevalence remains high in Eastern Mediterranean Region (EMR), and the impact of tobacco control efforts on cancer prevention is unclear. We assessed the potential impact of key policy interventions on tobacco-related cancer…
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Shared decision-making in Cervical Cancer Care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A mixed-methods study
Background: Shared decision-making is crucial for alignment of treatment options with patient values and preferences. However, currently in Ethiopia, shared decision-making in clinical care of cancer, in which cervical cancer is not exceptional, is not well understood. Aim: This study aimed to…
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Evaluation of plant diversity and soil-vegetation relationships in some salinity-affected cultivated areas in Egypt
Soil salinity, characterized by the accumulation of soluble salts, poses a significant global threat to agriculture, affecting over one billion hectares. It induces osmotic stress and ion toxicity, significantly diminishing crop yields and arable land. Egypt, heavily reliant on the Nile Delta…
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A prospective observational study evaluating the short-term effectiveness of residential care for adolescents as “service as usual”: A study protocol
Previous research indicates worse outcomes for children and young people in out-of-home care compared to their peers. To improve the quality of current residential care, research is needed to deepen our understanding of the key factors and mechanisms that explain the effectiveness of residential…
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Analysis of the current situation and influencing factors of emotional labor among pediatric nurses: A cross-sectional study
Aim: To examine the level and factors associated with emotional labor among pediatric nurses in Yichang, China. Methods: From December 20–25, 2024, a cross-sectional descriptive online study was conducted among 307 pediatric nurses in Yichang, China. The survey included general information…
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An optimized protocol for metabolic measurement in 3D tumor spheroids derived from primary and established glioblastoma cells
Tumors are characterized by a multitude of genetic and epigenetic alterations, including a deregulation of the metabolism, driving migration and infiltration. To mimic the energetic landscape of in vivo tumors, 3D models surpass traditional 2D cultures, by introducing regions of different nutrient…
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Optical coherence tomography angiography parameters in Marfan syndrome: Genetic determinants and associations with cardiovascular manifestations
In addition to aortic manifestations, Marfan syndrome can affect retinal vessels. Our aim was to evaluate retinal circulation, and its correlation with genotype and cardiovascular manifestation identifying predictors of aortic involvement (dilation and/or dissection). In the retrospective…
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Exploring proteomic signatures in sepsis and non-infectious systemic inflammatory response syndrome
Background: The search for new biomarkers that allow an early diagnosis in sepsis has become a necessity in medicine. This study aims to identify protein biomarkers that differentiate sepsis from non-infectious systemic inflammatory response syndrome (NISIRS), addressing the need for early sepsis…
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Clip-plate versus suture-anchor in double-door laminoplasty for degenerative cervical myelopathy: Protocol for a multicenter, non-inferiority, randomized controlled trial
Background: Degenerative cervical myelopathy (DCM) is a leading cause of spinal cord dysfunction. While cervical laminoplasty (LAMP) is the standard treatment, the optimal fixation method for the opened lamina, specifically between the conventional suture-anchor method and the modern plate system…
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Beyond broken homes: Why climate resilience must start with the human psyche
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Generalist large language models in a specialized world: Evidence from the Italian national medical education pathway
Creating language-specific and domain-specific large language models presents substantial challenges, including computational demands and limited data availability. While it is commonly believed that the benefits of specialized models justify these challenges, we dispute this notion with a…
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Sharing digital health data responsibly: Balancing open science with participant privacy
Data sharing is essential for modern science, advancing transparency, reproducibility, and discovery. Emerging evidence shows that certain digital health data, particularly high-frequency accelerometry from body-worn sensors, carry re-identification risks even when de-identified. In 2023, the…
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Factors affecting feeding choices in infants and toddlers in northern Jordan: A cross-sectional study
Background: Breastfeeding is a key determinant of infant health and survival; however, exclusive breastfeeding (EBF) rates remain low worldwide. Various maternal, infant, and socioeconomic factors influence the feeding practices. Objective: The main objective of this study was to identify maternal…
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Which are the most valued HIV pre-exposure prophylaxis attributes? A discrete choice experiment among sexual and gender minorities in Peru
Background: There is potential demand for pre-exposure prophylaxis (PrEP) in Peru; however, little is known about preferences towards PrEP modalities or the importance of PrEP attributes. Our research focused on which attributes most influence PrEP modalities choice among sexual and gender…
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Nine quick tips for software containerization
Software containerization has become a cornerstone of modern computational biology, enabling researchers to package code, dependencies, and execution environments in portable and reusable units. Containers support reproducibility, facilitate collaboration, and lower barriers to deploying complex…
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Targeting pancreatic cancer with combined inhibition of EGFR and RAF
Pancreatic cancer is the third leading cause of cancer-related death, with a 5-year survival rate of only 10%. Preclinical studies remain essential for identifying novel therapeutic strategies, discovering biomarkers, and deepening the understanding of disease biology. The most frequent driver…
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Association between muscle relaxant dosage and recovery in pediatric otolaryngological surgery: A retrospective cohort study
Background: Standardized guidelines for dosing strategies of muscle relaxants—specifically aimed at reducing extubation time and side effects—are currently lacking in pediatric otolaryngological surgery. This retrospective cohort study examined the association between induction dosages of…
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Comparative emission and energy performance of biochar production versus in-situ burning of Gorean agrobyproducts
Uncontrolled open-field burning of agricultural residues remains a pervasive source of air pollutants and greenhouse gases in Korea, particularly for high-burning-ratio crops such as perilla, pepper, pear, grape, and apple residues. This study provides a comprehensive assessment of the…
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Pregelatinized green banana flour snack bars: Physicochemical properties, sensory quality, and gastroprotective potential in an ethanol-induced ulcer model
Peptic ulcers remain a recurrent gastrointestinal disorder requiring preventive nutritional strategies. Functional foods that promote gastrointestinal health may play an important role in preventing and managing peptic ulcers. In this study, we evaluated pregelatinized green banana flour (GBF)…
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Development of a Loop-Mediated Isothermal Amplification (LAMP) for the screening of Candida auris
Background: Candida auris is an emerging multidrug-resistant yeast associated with invasive infections, healthcare-associated outbreaks, and high mortality, and is often misidentified by conventional diagnostic methods. Rapid, accurate, and scalable screening tools are essential for effective…
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