14 results for "Hannu Larjava"

Beyond the clot: how the biomolecular landscape of platelet-rich fibrin directs fibroblast functions

Jiarui Bi; Hannu Larjava; Lari Häkkinen

Frontiers in Oral Health, Vol. 6 · 2026 · English · DOAJ Scopus

Platelet-Rich Fibrin (PRF) is a second-generation autologous blood concentrate widely applied in regenerative medicine and dentistry for its wound-healing potential. Its clinical applications span dermatology, plastic surgery, periodontology, implantology, and oral maxillofacial surgery, with…

Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures

Rajesvaran Ramalingam; Guoqiao Jiang; Hannu Larjava et al.

Scientific Reports, Vol. 13 No. 1 · 2023 · English · DOAJ Scopus

Abstract Standard cell cultures are performed in aqueous media with a low macromolecule concentration compared to tissue microenvironment. In macromolecular crowding (MMC) experiments, synthetic polymeric crowders are added into cell culture media to better mimic macromolecule concentrations found…

Expression and function of connexin 43 in human gingival wound healing and fibroblasts.

Rana Tarzemany; Guoqiao Jiang; Hannu Larjava et al.

PLoS ONE, Vol. 10 No. 1 · 2015 · English · DOAJ Scopus

Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among C×s, suppressing C×43 expression or…

Also available at: PLOS

Decontamination of multispecies oral biofilm from rough implant surface by airflow with glycine

Kyla Leung; Jiarui Bi; Georgios Giannelis et al.

Clinical and Experimental Dental Research, Vol. 8 No. 1 · 2022 · English · DOAJ Scopus

Abstract Objectives Decontamination of biofilm‐colonized rough implant surfaces remains challenging. We investigated the effect of airflow with glycine powder (AFG) on decontamination of mature oral multispecies biofilm from a sandblasted and acid etched (SLA) titanium surface. Materials and…

Calcified carotid artery atheroma on standard dental radiographs: A public health opportunity for cardiovascular risk reduction

Vicky Mai; Aneesha Taneja; Hannu Larjava et al.

American Journal of Preventive Cardiology, Vol. 19 · 2024 · English · DOAJ Scopus

Objective: Calcified carotid artery atheroma (CCAA) can be identified incidentally on standard dental panoramic radiographs (DPRs). We sought to (1) determine the prevalence of CCAA on DPRs in a general dental population and (2) establish the proportion of patients in whom this would represent a…

Human Gingival Fibroblasts Display a Non-Fibrotic Phenotype Distinct from Skin Fibroblasts in Three-Dimensional Cultures

Wesley Mah; Guoqiao Jiang; Dylan Olver et al.

PLoS ONE, Vol. 9 No. 3 · 2014 · English · PLOS Scopus

Scar formation following skin injury can be a major psychosocial and physiological problem. However, the mechanisms of scar formation are still not completely understood. Previous studies have shown that wound healing in oral mucosa is faster, associates with a reduced inflammatory response and…

Also available at: DOAJ

Gingival epithelial cell-derived microvesicles activate mineralization in gingival fibroblasts

Shuichiro Kobayashi; Jiarui Bi; Gethin Owen et al.

Scientific Reports, Vol. 12 No. 1 · 2022 · English · DOAJ Scopus

Abstract Soft tissue calcification occurs in many parts of the body, including the gingival tissue. Epithelial cell-derived MVs can control many functions in fibroblasts but their role in regulating mineralization has not been explored. We hypothesized that microvesicles (MVs) derived from gingival…

Altered composition of the oral microbiome in integrin beta 6-deficient mouse

Osamu Uehara; Jiarui Bi; Deshu Zhuang et al.

Journal of Oral Microbiology, Vol. 14 No. 1 · 2022 · English · DOAJ Scopus

In periodontal disease (PD), bacterial biofilms suppress β6 integrin expression transforming growth factor-β1 signaling, resulting in gingival inflammation and bone loss. β6 integrin-null (Itgb6−/−) mice develop spontaneous PD. The aim of this study was to unravel potential differences in oral…

Scanning electron microscopic analysis of adherent bacterial biofilms associated with peri‐implantitis

Jae W. Chang; Jiarui Bi; Gethin Owen et al.

Clinical and Experimental Dental Research, Vol. 9 No. 4 · 2023 · English · DOAJ Scopus

Abstract Objectives Peri‐implantitis (PI) is caused by bacteria in the peri‐implant space but the consensus on microbial profile is still lacking. Current microbial sampling of PI lesions has largely focused on analyzing bacterial species that have been shed from the implant surface and captured in…

Melanoma-Associated Cancer-Testis Antigen 16 (CT16) Regulates the Expression of Apoptotic and Antiapoptotic Genes and Promotes Cell Survival

Camilla Nylund; Pekka Rappu; Eveliina Pakula et al.

Public Library of Science · 2012 · English · PLOS Scopus

Cancer-testis (CT) antigens are predominantly expressed in testis or placenta, but absent in most adult tissues. During malignant transformation CT genes are often activated. CT antigen 16 (CT16, PAGE5) is frequently expressed in advanced melanoma but its biological function has been unknown. To…

Also available at: DOAJ

Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells

Jiarui Bi; Leeni Koivisto; Aihui Pang et al.

Scientific Reports, Vol. 7 No. 1 · 2017 · English · DOAJ Scopus

Abstract Periodontal diseases manifest by the formation of deep pockets between the gingiva and teeth where multispecies bacterial biofilms flourish, causing inflammation and bone loss. Epithelial cell receptor αvβ6 integrin that regulates inflammation by activating the anti-inflammatory cytokine…