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The association of preoperative psychological assessments with long-term sleeve gastrectomy surgery outcomes
Background: Nearly all third-party healthcare plans adhere to the 1991 National Institutes of Health guidelines, which require preoperative psychological assessments before bariatric surgery. Despite these guidelines, the impact of these assessments on the long-term weight loss outcomes in…
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JMJD3 regulates the M2-like macrophage polarization and promotes the growth of breast cancer cells via STAT6/IRF4 axis
M2-like macrophages play a critical role in breast cancer progression. Although JMJD3 is reported to play a significant role in M2-like macrophage polarization, its precise mechanism remains unclear. By using PMA, IL-4, and IL-13, we successfully induced THP-1 cells into M2-like macrophages, which…
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Day–night variation and age-related differences in gadolinium-based contrast media enhancement in the brain: A T1 mapping study
The glymphatic system clears metabolic waste from the brain and can be probed using contrast-enhanced MRI. We investigated whether early-phase gadolinium-based contrast agent (GBCA) uptake varies with time of day and age. In this retrospective study, 447 patients who underwent brain MRI for…
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Towards dignified healthcare: Patients’ understanding and experiences of respectful and disrespectful care in healthcare facilities in Ghana
Respectful and disrespectful care profoundly influence communication and collaboration between caregivers and patients, shaping outcomes across the continuum of care. Despite patients being the primary users of healthcare services, their experiences of respectful and disrespectful care remain…
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Antibacterial potential of epiphytic fungi obtained from brown algae of Kenyan coastal waters
The rapid rise of antimicrobial resistance, coupled with the limited development of new therapeutic agents, is a critical public health concern that needs urgent and innovative interventions. Marine fungi represent an important but still largely unexplored source of novel and diverse secondary…
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Collaborative mapping: Perceived environmental risk of leptospirosis in Urban communities in Salvador, Brazil
Environmental risks disproportionately affect socially vulnerable populations, yet most studies on urban leptospirosis have not captured residents’ perceptions of these risks. We conducted a cross-sectional study between August 2018 and March 2019 across four communities in Salvador, Brazil…
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The impact on healthcare facilities of the 2024 IV fluids shortage after Hurricane Helene: A mixed methods study
Background: In September 2024, Hurricane Helene damaged the Baxter International Factory in North Carolina as well as the surrounding infrastructure, causing the factory to shut down production. This resulted in a nationwide shortage of intravenous (IV) fluids. This study sought to characterize the…
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IGF1/IGF-1R promotes hepatocellular carcinoma progression by activating the Akt/GSK-3β pathway
The incidence of hepatocellular carcinoma (HCC) is increasing each year, with challenges such as increasing drug resistance and a high post-treatment recurrence rate. Therefore, investigating the novel pathogenic mechanisms is warranted. In this study, we investigated novel molecular mechanisms…
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The correction of the urban-rural wealth Gini coefficient of China
Due to the lack of top wealth records in household surveys, many scholars believe that China’s wealth Gini coefficient is seriously underestimated. Based on data from CFPS (China Household Panel Survey), this paper corrects the urban-rural wealth Gini coefficient of China in combination with the…
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Subgroup identification of disparities in buprenorphine discontinuation in opioid-use disorder: A Virtual Twins machine learning approach using nationwide United States claims data, 2006–2022
Buprenorphine retention is crucial for effective treatment of opioid use disorder (OUD), yet disparities in treatment discontinuation persist. This study aims to identify and quantify disparities in buprenorphine treatment retention using a machine learning framework adapted from Virtual Twins…
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A Core Outcome Set to evaluate the impact of prognostication in people living with advanced cancer: An international consensus study
Background: Implementing a prognostic model in clinical practice requires assessing not just its accuracy but also how it may impact patient and healthcare outcomes. Evaluating these impacts requires clinical trials that are carefully designed to select, collect, and report key outcomes. However…
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Molecular identification and microbiome profiling of household casebearer, Phereoeca sp. (Lepidoptera: Tineidae) from Malaysia: Potential implications for human skin irritation
In Malaysia, anecdotal accounts have linked the household casebearer (Lepidoptera: Tineidae) to skin lesions and localized inflammation; however, scientific evidence is lacking, and the species’ taxonomic identity remains unclear. This study aimed to confirm the species identity and examine the…
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Characterizing the linguistic profiles, training needs, and caseloads of speech language pathologists providing clinical services to multilingual people with aphasia: The international Multilingual Aphasia Practices (MAP) consensus group survey
Globally, there is still limited understanding of how Speech-Language Pathologists (SLPs) assess and treat multilingual people with aphasia (MPWA). This article presents results from the Multilingual Aphasia Practices (MAP) survey—an extensive international study involving 407 SLPs working across…
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Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and incidence of asthma and wheeze in childhood: A register-based cohort study in Ronneby, Sweden
Background: Early-life exposure to per- and polyfluoroalkyl substances (PFAS) may impact the developing lungs and immune system and increase the risk of childhood asthma, but no studies have been conducted in a high-exposed population. The objective of this study was to estimate associations…
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Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study
Background: Clinical guidance in Canada and the United States recommends faster methadone dose titration for individuals using fentanyl. An initial dose increase is recommended between days 4 and 6, but the impact on patient outcomes remains unclear, particularly when provided in an outpatient…
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The first non-mammalian synapsid embryo from the Triassic of South Africa
Oviparity was likely the plesiomorphic reproductive condition for non-mammalian Synapsida, the stem-mammal group. Yet, despite nearly two centuries of research, no definitive fossil eggs of late Palaeozoic or early Mesozoic synapsids have been discovered. Here, three perinate specimens of the…
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