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Artikel Jurnal
10.23812/j.biol.regul.homeost.agents.20243804.256
Background: Osteosarcoma (OS) is the most prevalent primary malignant bone tumor among adolescents, yet the efficacy of current medications is limited by a lack of understanding of the molecular mechanisms underpinning OS growth and metastasis. In previous studies, cantharidin (CTD), an effective…
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Advances in diagnosis and treatment of bladder cancer
Bladder cancer remains a leading cause of cancer death worldwide and is associated with substantial impacts on patient quality of life, morbidity, mortality, and cost to the healthcare system. Gross hematuria frequently precedes the diagnosis of bladder cancer. Non-muscle-invasive bladder cancer…
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Harnessing the Power of LLMs in Practice: A Survey on ChatGPT and Beyond
This article presents a comprehensive and practical guide for practitioners and end-users working with Large Language Models (LLMs) in their downstream Natural Language Processing (NLP) tasks. We provide discussions and insights into the usage of LLMs from the perspectives of models, data, and…
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Multiple myeloma: 2024 update on diagnosis, risk‐stratification, and management
DISEASE OVERVIEW: Multiple myeloma accounts for approximately 10% of hematologic malignancies. DIAGNOSIS: The diagnosis requires ≥10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal…
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Hardware implementation of memristor-based artificial neural networks
Artificial Intelligence (AI) is currently experiencing a bloom driven by deep learning (DL) techniques, which rely on networks of connected simple computing units operating in parallel. The low communication bandwidth between memory and processing units in conventional von Neumann machines does not…
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Titanium-Based alloys and composites for orthopedic implants Applications: A comprehensive review
The increasing demand for orthopedic implants has driven the search for materials that combine strength, biocompatibility, and long lifetime. Compared to stainless steel and Co-Cr-based alloys, titanium (Ti) and its alloys are favored for biomedical implants because of their high strength…
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Developing clinical prediction models: a step-by-step guide
Predicting future outcomes of patients is essential to clinical practice, with many prediction models published each year. Empirical evidence suggests that published studies often have severe methodological limitations, which undermine their usefulness. This article presents a step-by-step guide to…
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AI in diagnostic imaging: Revolutionising accuracy and efficiency
This review evaluates the role of Artificial Intelligence (AI) in transforming diagnostic imaging in healthcare. AI has the potential to enhance accuracy and efficiency of interpreting medical images like X-rays, MRIs, and CT scans. A comprehensive literature search across databases like PubMed…
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Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K…
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Detection of mosaic and population-level structural variants with Sniffles2
Calling structural variations (SVs) is technically challenging, but using long reads remains the most accurate way to identify complex genomic alterations. Here we present Sniffles2, which improves over current methods by implementing a repeat aware clustering coupled with a fast consensus sequence…
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Corporate Climate Risk: Measurements and Responses
Abstract This paper conducts a textual analysis of earnings call transcripts to quantify climate risk exposure at the firm level. We construct dictionaries that measure physical and transition climate risks separately and identify firms that proactively respond to climate risks. Our validation…
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Understanding the complexity of p53 in a new era of tumor suppression
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GWTC-2.1: Deep extended catalog of compact binary coalescences observed by LIGO and Virgo during the first half of the third observing run
GWTC-2.1 is a catalog of gravitational wave events from compact binary coalescences from the first half of the third observing run of Advanced LIGO and Advanced Virgo. It improves on GWTC-2, which covered the same period but with less refined analysis methods. GWTC-2.1 identifies 8 new events, all…
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Structural Improvement in Crane Boom Rest
Crane boom rests are critical components that endure both static and dynamic loads, leading to deformation and a shortened lifespan. This paper addresses these issues by proposing a redesigned model with enhanced stiffness and load-bearing capacity. The new design incorporates gussets and…
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ASF-YOLO: A novel YOLO model with attentional scale sequence fusion for cell instance segmentation
We propose a novel Attentional Scale Sequence Fusion based You Only Look Once (YOLO) framework (ASF-YOLO) which combines spatial and scale features for accurate and fast cell instance segmentation. Built on the YOLO segmentation framework, we employ the Scale Sequence Feature Fusion (SSFF) module…
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The NANOGrav 11-year data set: High-precision timing of 45 millisecond pulsars
We present high-precision timing data over time spans of up to 11 years for 45 millisecond pulsars observed as part of the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) project, aimed at detecting and characterizing low-frequency gravitational waves. The pulsars were…
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A triple increase in global river basins with water scarcity due to future pollution
Abstract Water security is at stake today. While climate changes influence water availability, urbanization and agricultural activities have led to increasing water demand as well as pollution, limiting safe water use. We conducted a global assessment of future clean-water scarcity for 2050s by…
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A review of battery energy storage systems and advanced battery management system for different applications: Challenges and recommendations
Energy storage systems are designed to capture and store energy for later utilization efficiently. The growing energy crisis has increased the emphasis on energy storage research in various sectors. The performance and efficiency of Electric vehicles (EVs) have made them popular in recent decades…
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